MedFlow is a class‑aware multi‑scale flow matching framework designed to synthesize medical time‑series data. It uses a vector‑quantized multi‑scale tokenizer to capture both coarse and fine temporal patterns, and introduces Token Marginal Guidance to steer generation toward minority‑class characteristics. Experiments on four public datasets show MedFlow outperforms diffusion baselines, improving AUPRC by 5.8%, reducing Context‑FID by 88.6%, and achieving 3.8× higher sampling throughput.
By Yanhao Huang, Shibo Feng, Wanjin Feng, Peilin Zhao, Chunyan Miao
NOAH is a generative transformer that models the entire multimodal patient journey by integrating bidirectional time and a variational latent space to capture continuous, stochastic clinical trajectories. Trained on over 559 million events from 431,000 hospital visits, it processes medical images, time‑series, numeric signals, categorical events, and both structured and unstructured records. The model supports autoregressive forecasting, zero‑shot classification, and counterfactual simulations, yielding strong predictive performance across 15 ICD chapters, 29 comorbidities, and time‑to‑event outcomes.
Many clinical prediction models treat post-intervention outcomes as a one-step mapping from baseline measurements to a future endpoint. However, recovery after a procedure often unfolds as an irregular trajectory: clinical observations, medication changes, repeat interventions, and physiological measurements are recorded asynchronously and can change risk assessment over time.
arXiv:2607. 22114v1 Announce Type: new Abstract: Autoregressive foundation models for electronic health records (EHRs) typically inherit pretraining methods from language modeling, where patient trajectories are concatenated into a single token stream and windows are sampled from that stream.
By Joshua Placidi, Yuxuan Liu, Jinpei Han, Marek Rei, A. Aldo Faisal
arXiv:2608. 13518v1 Announce Type: new Abstract: Many clinical prediction models treat post-intervention outcomes as a one-step mapping from baseline measurements to a future endpoint.
By Yunsung Chung, Yingshuo Liu, Abboud F. Hassan, Han Feng, Mary M. Maleckar, Nassir Marrouche, Jihun Hamm
NOAH is a generative transformer that learns the full multimodal patient journey by integrating bidirectional time and a variational latent space. Trained on over 559 million clinical events from 431,000 hospital visits, it processes medical images, time‑series, numeric signals, categorical events, and both structured and unstructured records. The model supports autoregressive forecasting, zero‑shot classification, and counterfactual intervention simulation, yielding strong performance on clinical outcomes, ICD chapters, comorbidities, and time‑to‑event prediction.
By Tobias Susetzky, Raphael Rehms, Dmitrii Seletkov, \"Ozg\"un Turgut, Michelle Espranita Liman, Lisa Steinhelfer, Rickmer Braren, Daniel Rueckert
arXiv:2607. 15447v1 Announce Type: new Abstract: Recent research in clinical machine learning, focusing on outcome predictions in intensive care unit (ICU), has shifted from bespoke supervised models to foundation models, utilising modern representation learning methods.
By Jingteng Li, Alexander Capstick, Louise Rigny, Iona Biggart, Neil J Sebire, Payam Barnaghi
arXiv:2506. 04831v3 Announce Type: replace Abstract: Forecasting how a patient's condition is likely to evolve, including possible deterioration, recovery, treatment needs, and care transitions, could support more proactive and personalized care, but requires modeling heterogeneous and longitudinal electronic health record (EHR) data.
By Chantal Pellegrini, Ege \"Ozsoy, David Bani-Harouni, Matthias Keicher, Nassir Navab
arXiv:2607. 08793v1 Announce Type: cross Abstract: Sepsis is a leading cause of mortality, yet optimal treatment policies remain contested.
By Joshua Pickard, Wei Qi, Na Li, Ann Woolley, Lisa Cosimi, Roy Kishony, Deborah Hung
The paper proposes a reinforcement learning (RL) fine‑tuning framework for electronic health record (EHR) foundation models, treating them as generative policies over patient trajectories. By framing clinical prediction tasks such as hospital readmission as event‑conditioned, time‑windowed reasoning problems and designing time‑aware, rollout‑sensitive rewards, the authors show that RL fine‑tuning consistently outperforms pre‑trained backbones and strong baselines. The approach enables smaller models to surpass larger pre‑trained models in data‑limited settings, induces positive transfer across tasks, and produces trajectories with stronger structural and semantic alignment to ground truth, improving downstream utility.
By Yuxin Xiao, Sheng Zhang, Chandan Singh, Tristan Naumann, Hoifung Poon, Jianfeng Gao, Xiaodong Liu
arXiv:2512. 08029v3 Announce Type: replace Abstract: Clinical decision-making in oncology requires predicting dynamic disease evolution, a task current static AI predictors cannot perform.
By Tianxingjian Ding, Yuanhao Zou, Chen Chen, Mubarak Shah, Yu Tian
arXiv:2606. 05797v1 Announce Type: new Abstract: Longitudinal treatment decisions require predicting potential outcomes under future treatment sequences in the presence of time-varying confounding, heterogeneous patient dynamics, and limited domain-specific data.
By Amirhossein Zare, Amirhessam Zare, Herlock Rahimi, Reza Salarikia, Mohammad Kashkooli