SepsisLens is a new model for early sepsis warning that preserves the structure of individual physiological signals while predicting risk. It uses observation-aware representations to encode each variable’s dynamics and a shared temporal encoder to maintain variable axes, then composes multi-horizon risk through a StructuredRiskHead that includes variable-level and organ-level components. The model was evaluated on three public ICU cohorts and one private-hospital cohort, achieving strong discrimination and lower alert burden at matched recall on MIMIC-IV, with ablations confirming the design choices.
By Yikun Ou, Wei Li
arXiv:2609.36144v1 Announce Type: new
Abstract: Electronic health records provide irregular observations of latent patient states that evolve continuously over time. Recent autoregressive models cond...
By Silas Ruhrberg Est\'evez, Kara Liu, Christopher Chiu, Benjamin Atta Owusu, Umesh Kadam, Russ B. Altman, Mihaela van der Schaar
arXiv:2608. 15309v1 Announce Type: new Abstract: Continuous multimodal sensing now allows human physiology to be observed throughout daily life rather than only during occasional clinical visits.
By Chongyang Zhang, Rendong Wang, Hao Zheng, Hanwen Zhang, Yang Liu, Xiaolong Wei, Bin Chong
arXiv:2607. 08793v1 Announce Type: cross Abstract: Sepsis is a leading cause of mortality, yet optimal treatment policies remain contested.
By Joshua Pickard, Wei Qi, Na Li, Ann Woolley, Lisa Cosimi, Roy Kishony, Deborah Hung
arXiv:2607. 19020v1 Announce Type: cross Abstract: Background: Clinical decision support systems degrade silently as treatment protocols evolve, yet standard adaptation methods treat models as monolithic blocks, unable to distinguish stable patient physiology from shifting institutional practice.
By Fatema Ferdous Tamanna, K. M. Merajul Arefin, Md. Abdul Masud
The paper introduces a bounded updating framework for ICU prediction models that freezes the physiological encoder while allowing updates only to the treatment pathway and fusion head. Experiments on 84,792 MIMIC-IV ICU stays across four temporal shifts show that selective adaptation yields more stable explanations—higher rank correlation, better top‑5 feature agreement, and improved retrieval stability—compared to full model adaptation. Predictive performance varies by outcome, but the results demonstrate that explanation stability is governed by the structural boundaries of allowed adaptation rather than merely by freezing components.
By Fatema Ferdous Tamanna, K. M. Merajul Arefin, Md. Abdul Masud
arXiv:2610.17059v1 Announce Type: new
Abstract: Clinical decisions depend on anticipating how a patient's condition will evolve as treatment is adjusted and new evidence becomes available. Existing m...
By Ziwen Kan, Jie Peng, Bo Yan, Davis Hobley, Zheng Zhang, Yu Tian, Tianlong Chen, Song Wang
arXiv:2608.29301v1 Announce Type: new
Abstract: Predicting future organ dysfunction in Intensive Care Unit (ICU) patients is critical for early clinical intervention, yet existing machine learning ap...
By Razan Albouq, Asra Aslam
The paper presents a Time-Aware transformer-based model designed to predict Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD) using only respiratory data from daily-use ventilators. By capturing symptom patterns and their temporal progression, the model generates meaningful patient representations and outperforms traditional methods across multiple classification tasks. This approach aims to provide timely detection of AECOPD while minimizing latency associated with clinical and laboratory data.
By Weihao Qu, Ling Zheng, Dongyang Wang, Jiacun Wang, Haowen Pan
arXiv:2608. 19578v1 Announce Type: new Abstract: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) can worsen rapidly, making timely prediction a clinical priority.
By Dongyang Wang, Weihao Qu, Ling Zheng, Haowen Pan
arXiv:2510. 15127v3 Announce Type: replace-cross Abstract: Identifying the effects of mechanical ventilation (MV) protocols in critical care requires analyzing data from heterogeneous patient-ventilator systems in the clinical decision-making environment.
By David J. Albers, Tell D. Bennett, Jana de Wiljes, George Hripcsak, Bradford J. Smith, Peter D. Sottile, J. N. Stroh
arXiv:2608. 10969v1 Announce Type: new Abstract: Healthcare data, such as Intensive Care Unit (ICU) records, comprise heterogeneous multivariate time series sampled at irregular intervals with pervasive missingness.
By Ruirui Wang, Yanke Li, Manuel G\"unther, Diego Paez-Granados