The paper introduces Empirical Research Assistance (ERA), an autonomous system that employs Large Language Model‑guided tree search to create, evaluate, and refine executable forecasting software for infectious diseases. In a real‑time evaluation during the 2025‑26 U.S. respiratory season, ERA produced diverse models for influenza, COVID‑19, and RSV, and an ensemble of these models outperformed the CDC’s gold‑standard forecast ensembles across all three pathogens. ERA also demonstrated robustness in data‑scarce RSV scenarios and showed that higher‑tier language models and specific optimization metrics can improve forecast accuracy.
By Sarah Martinson, Michael P. Brenner, Martyna Plomecka, Brian P. Williams, Nicholas G. Reich, Zahra Shamsi
arXiv:2607. 19262v1 Announce Type: new Abstract: As pathogen genomic surveillance scales, the bottleneck is shifting from data generation to analysis.
By Harmon Bhasin, Kevin Flyangolts, Dianzhuo Wang, Evan Seeyave, Arjun Banerjee, Amanda Darling, Joshua Stallings, David Stern, Shawn Higdon, Claire Duvallet, Bryan Tegomoh, Kenny Workman
OpenDiscoveryTrace is a public dataset of 558 complete AI scientific agent trajectories that records the reasoning process—thoughts, tool calls, observations, errors, revision triggers, and confidence—across 124 scientific tasks in drug discovery, materials science, genomics, and literature analysis. The dataset includes seven models (three frontier models and four open‑weight models) and 60 live‑retrieval variants, providing a balanced view of performance and error patterns. Pilot analysis shows that process traces reveal behavioral differences invisible to output‑only evaluation, such as differing error rates and types among frontier models.
By Aayam Bansal, Keertan Balaji
arXiv:2609.07611v1 Announce Type: new
Abstract: Scientific ideation is the capacity to formulate novel and testable hypotheses from scientific evidence, and autonomous AI scientists depend on it. Exi...
By Yunxiang Mo, Tianshi Zheng, Yisen Gao, Rui Wang, Newt Nguyen Kim Hue Nam, Kelvin Kiu Wai Tam, Jiaxin Bai, Yangqiu Song, Ginny Wong, Simon See
arXiv:2609.35561v2 Announce Type: replace
Abstract: Recursive self-improvement (RSI) seeks to enable AI systems to participate in improving their own capabilities. A concrete pathway is autonomous mo...
By Yaxin Du, Xiyuan Yang, Zhifan Zhou, Yujie Ge, Cheng Wang, Jiajun Wang, Sijie Chen, Zehui Liu, Yuxin Zhang, Weicheng Gu, Julian Zhang, Zixing Lei, Siheng Chen
DataSense-Bench is a new benchmark that tests whether advanced AI models can choose and rank training data subsets that will improve a small language model’s performance. The benchmark lets agents inspect data, run analysis code, and perform forward passes, but not train the model or access evaluation tasks. After agents select subsets, the base model is fine‑tuned on each subset and evaluated, measuring both the performance of the best subset and the accuracy of the agents’ rankings. Experiments show limited gains over random selection and inconsistent ranking ability across tasks, with agents often using similar data signals but interpreting their value differently.
By Yudi Zhang, Mingyu Cao, Lu Yin, Mykola Pechenizkiy, Shiwei Liu
arXiv:2610.34644v1 Announce Type: new
Abstract: AI agents are increasingly proposed as autonomous experimenters, yet the benchmarks that test them mostly offer cheap experiments that answer at once....
By Ningpei Ding, Zai Wen Feng
The paper introduces AgentX-Model, a dual‑agent framework that links proposal development with model experimentation in industrial recommender systems. The Research Agent drafts proposals from literature and prior findings, while the Model Agent runs multi‑round experiments, returning code, metrics, and open questions. The framework iteratively selects starting implementations and formulates new research questions, organizing work into Reproduce, Follow‑up, Composition, and Diagnose actions. Across production evaluations, most experiments exceeded business baselines, with recent A/B tests showing significant gains in acquisition efficiency, advertising spend, and watch time while reducing computational cost.
By Shuang Yang, Zijie Zhuang, Changxin Lao, Pengbo Xu, Hanwen Xu, Yusheng Huang, Han Gao, Guanchen Wang, Tianbao Ma, Linxun Chen, Peilin Song, Xuming Wang, Chen Li, Fan Wu, Tao Wang, Zibo Zhao, Xiangyu Wu, An Liu, Fei Pan, Peng Jiang, Chen Yang, Zhaojie Liu, Wenwu Ou
MLE-World is a world model fine‑tuned from Qwen3.5‑4B that predicts the terminal output of a machine learning program—such as error traces, training logs, and validation scores—directly from its code and data description, without executing the program. It also provides a confidence score indicating the likelihood that the prediction is correct. Using these predictions, the authors design five test‑time‑scaling policies that compare multiple candidate programs per step, executing only those with low confidence, and demonstrate that MLE‑World matches real outputs on 77.9% of held‑out programs and improves agent performance by up to 22.1% with fewer real executions.
By Brian Ko, Han Wang, Hejia Geng, Li Erran Li, Sherry Yang
arXiv:2608.31076v1 Announce Type: cross
Abstract: Autonomous scientific research agents are increasingly applied to end-to-end scientific workflows, including literature review, data analysis, experi...
By Xuehai Wang, Haowei Qin, Tongxin Liu, Junkai Li, Buqiang Xu, Jintian Zhang, Yijun Chen, Zirui Xue, Shumin Deng
arXiv:2607. 05462v2 Announce Type: replace-cross Abstract: As AI agents are incorporated into life science workflows, the capabilities that speed discovery might also enable misuse.
By Edwin H. Wintermute, Harmon Bhasin, Christina M. Agapakis, Dianzhuo Wang, Evan Seeyave, Arjun Banerjee, Daniel Fulop, Matthew C. Watson, Adam J. Meyer, Sandrine Boissel, Jens H. Kuhn, Rishi Jain, Noah D. Taylor, Helena Shomar, Patrick M. Boyle, Kenny Workman
arXiv:2609.33357v2 Announce Type: replace
Abstract: Reliable automated research requires agents to vet data, verify analyses, and generate hypotheses grounded in trustworthy evidence, potentially red...
By Nan Huang, Mario Tapia-Pacheco, Kun Zhou, Yiming Huang, Kevin Jos\'e Barrientos D\'iaz, Tiffany Amariuta, Jingbo Shang