arXiv:2609.32807v2 Announce Type: replace
Abstract: Clinical LLM evaluation often emphasizes answer accuracy; however, accuracy alone does not test counterfactual consistency or demographic robustnes...
By Chaitali Deb Purkayastha, Bharath Kumar Bolla, Vishnu Surya Reddy Nandi
The paper investigates how uncertainty quantification fails in selective prediction systems when clinical data exhibit severe class imbalance, leading to systematic exclusion of minority patients. Through experiments on 56 synthetic scenarios and three neurodegenerative disease cohorts, the authors show that standard uncertainty measures become proxies for class membership rather than true ambiguity, and that combining class‑aware correction (CCR) with threshold‑aware metrics restores proper monotonicity and protects minority patients. The study proposes adopting threshold‑aligned uncertainty measures and class‑stratified evaluation to mitigate this bias and improve safety in clinical AI pipelines.
By Walter Endrizzi, Flavio Ragni, Raffaele Marchesi, Stefano Bovo, Monica Moroni, Giuseppe Jurman, Venet Osmani
The paper introduces EDGE, a closed‑form statistical test for assessing the calibration of probabilistic binary classifiers, specifically logistic regression. EDGE uses the same binned predicted‑versus‑observed table as a reliability diagram, projects standardized bin residuals onto a small basis of smooth calibration‑distortion shapes, and yields a null distribution that is a weighted sum of chi‑square variables. The method requires only a single pass over the data and a small eigendecomposition, avoiding refitting, resampling, or tuning, and remains robust in sparse or misspecified settings where other binned tests fail.
By Ebrahim Khaled Ebrahim, Ahmed El-Kotory
arXiv:2608.03854v4 Announce Type: replace
Abstract: Quantized large language models can run on consumer hardware, which motivates interest in on-premises processing of sensitive data. The reliability...
By Anton Rasmussen, Hong Qin
arXiv:2610.20417v1 Announce Type: new
Abstract: Audits of large language model (LLM) extraction from full-length documents report severe unreliability, leaving two questions open: what the failures a...
By Jiahong Qian
arXiv:2603. 25112v2 Announce Type: replace-cross Abstract: Standard evaluation of LLM confidence relies on calibration metrics (ECE, Brier score) that conflate how much a model knows (Type-1 accuracy) with how well its confidence signal tracks that knowledge (Type-2 metacognitive sensitivity).
By Jon-Paul Cacioli
arXiv:2610.28522v1 Announce Type: new
Abstract: Decision models support routing, guardrails, and output verification in LLM systems. However, item accuracy alone cannot establish whether models make...
By Xialie Zhuang, Mingcong Lei, Zunhai Su, Ri Liu, Jianjin Li, Peixian Ma, Jia Pan, Ngai Wong, Guanhua Chen, Chuan-Wei Kuo
arXiv:2608.30568v1 Announce Type: cross
Abstract: Background: Population level assessments of predictive artificial intelligence (AI) can conceal performance disparities across subgroups. Fairness ev...
By Jo\~ao Matos, Ben Van Calster, Richard D. Riley, Paula Dhiman, Gary S. Collins
The paper introduces Counterfactual Fragility Certificates (CFC), a model‑agnostic audit protocol that maps each prediction to an evidence‑failure trajectory, summarizing it with metrics such as greedy flip budget, margin‑collapse area, degradation thresholds, and fragility dominance score. CFC is shown to identify brittle high‑confidence predictions on seven tabular benchmarks with an AUROC of 0.915, outperforming existing scalar scores by up to +0.405. The method remains effective across various perturbation and review‑budget scenarios, and can also inform fragility‑aware regularization and temperature correction.
By Filippo Cenacchi, Longbing Cao, Runze Yang
The paper introduces an uncertainty‑mapping framework for periventricular Fazekas score prediction, moving beyond standard performance metrics. By linking uncertainty to positions in the learned feature space, it identifies class‑boundary regions where predictions are ambiguous and highlights potential label disagreements. The study shows that different loss functions affect the uncertainty profile, with some models achieving clearer class separation and more localized uncertainty.
By Susanne Schmid, Johanna Ospel, Richard Frayne, Roberto Souza
The study evaluates large language models (LLMs) on unprocessed electronic medical record data for clinical registry abstraction, focusing on the American College of Cardiology National Cardiovascular Data Registry. In a pilot at one academic center, the LLM identified candidate data sources for each registry question, which abstractors used to define question‑specific document sets. In a subsequent validation at a second center, the LLM answered 157 registry questions with an overall mean accuracy of 91.5%, but accuracy dropped from 96% for simple medication or event flag questions to 62% for event timing questions, reflecting increasing ambiguity and required clinical reasoning.
By James Matheson, Betsy Castillo, Andrew Y. Shin, David Scheinker
The paper introduces a new taxonomy for benchmark contamination that categorizes leakage by the mitigation it defeats—direct, derivative, temporal, distributional, and acquired—covering both training‑time and evaluation‑time scenarios. It proposes a four‑field disclosure protocol to record contamination status alongside benchmark scores, and provides a JSON schema, validator, and examples. An empirical study of 41 documents using a pre‑registered instrument shows limited reporting of contamination types and variable reliability, highlighting gaps in current disclosure practices.
By Johanna Angulo, V\'ictor Yeste, Hector Espinos-Morato