The study evaluates large language models (LLMs) on unprocessed electronic medical record data for clinical registry abstraction, focusing on the American College of Cardiology National Cardiovascular Data Registry. In a pilot at one academic center, the LLM identified candidate data sources for each registry question, which abstractors used to define question‑specific document sets. In a subsequent validation at a second center, the LLM answered 157 registry questions with an overall mean accuracy of 91.5%, but accuracy dropped from 96% for simple medication or event flag questions to 62% for event timing questions, reflecting increasing ambiguity and required clinical reasoning.
arXiv:2608. 09080v1 Announce Type: cross Abstract: Large Language Models (LLMs) have achieved strong performance in medical question answering and clinical reasoning tasks.
arXiv:2606. 05970v1 Announce Type: cross Abstract: Large language models are increasingly used for structured extraction from clinical free-text notes, but the sensitivity of their output to upstream configuration choices is less understood than their accuracy on fixed benchmarks.
arXiv:2606. 03198v1 Announce Type: cross Abstract: Clinical AI evaluation increasingly delegates scoring to large language models (LLMs) acting as AI raters, yet their scoring behavior across evaluation conditions has not been quantitatively characterized.
arXiv:2503. 10647v2 Announce Type: replace-cross Abstract: This study evaluated the diagnostic reliability of two Large Language Models (LLMs), Google Gemini 2.
The study evaluates whether large language models (LLMs) with in‑context learning can better identify institution‑specific protected health information (PHI) in electronic health records than existing de‑identification systems. Using 100 pediatric oncology notes from Texas Children’s Hospital, eight LLMs were compared to two purpose‑built systems and pattern‑based baselines under three progressively specific prompts. The best LLM achieved an F1 score of 0.918, recovering 79% of previously missed PHI categories and reaching a recall of 0.981 after iterative prompt refinement, demonstrating that calibrated single‑pass prompting can close the institutional PHI gap while balancing precision and recall.
arXiv:2606. 19509v1 Announce Type: new Abstract: Large language models (LLMs) are increasingly applied to structured clinical data, yet whether they can recognize the limits of their own knowledge on such tasks remains unexplored.
arXiv:2607. 13036v1 Announce Type: cross Abstract: Large language models (LLMs) are increasingly used for decision support in healthcare, but clinical evidence is often incomplete or evolving.
arXiv:2607. 28677v1 Announce Type: new Abstract: LLM now pass medical licensing examinations and, in curated cases, can rival physicians at diagnostic reasoning.
arXiv:2607. 02175v1 Announce Type: new Abstract: Multiple-choice medical benchmarks are increasingly saturated, and recent rubric-based evaluations such as HealthBench have shown that open-ended clinical performance is far from solved - its "Hard" subset top score remains 32%.
arXiv:2509. 02594v3 Announce Type: replace-cross Abstract: Evaluating large language models (LLMs) on their ability to generate high-quality, accurate, situationally aware answers to clinical questions requires going beyond conventional benchmarks to assess how these systems behave in complex, high-stakes clinical scenarios.
arXiv:2606. 16890v1 Announce Type: cross Abstract: Aggregate accuracy benchmarks conceal a systematic structure in how large language models fail at electronic health record (EHR) question answering: questions requiring more inferential steps produce disproportionately more errors.
arXiv:2606. 15735v1 Announce Type: cross Abstract: Discharge summaries are crucial clinical documents containing the context of a patient's overall hospital stay, and are routinely reviewed by medical experts for patient readmission, ongoing care, and diagnostic decision-making.