MODIS is a semi‑supervised framework for integrating multi‑omics data that are often unpaired, partially labeled, and scarce, such as in rare disease studies. It trains on a large reference database and a small target dataset simultaneously, using diagonal integration and class‑label alignment to handle class imbalance. The architecture combines variational auto‑encoders, a class classifier, and an adversarially trained modality classifier, with a regularized relativistic GAN loss for stable training, and demonstrates high accuracy on synthetic data and the TCGA cancer dataset.
arXiv:2606. 05139v1 Announce Type: new Abstract: The rapid advancement of high-throughput sequencing has led to large, high-dimensional omics datasets.
arXiv:2607. 10196v1 Announce Type: new Abstract: Access to sufficiently large biomedical datasets remains a major obstacle for machine learning in Raman spectroscopy-based diagnostics.
arXiv:2512.09365v2 Announce Type: replace Abstract: Predicting molecule-protein interactions (MPIs) is a fundamental task in computational biology, with crucial applications in drug discovery and mol...
arXiv:2609.14072v1 Announce Type: new Abstract: Large Language Models (LLMs) have displayed impressive capabilities in handling tasks that require few demonstration examples, making them effective fe...
arXiv:2605. 31014v2 Announce Type: replace Abstract: Multi-omics data provide complementary molecular characterizations of disease phenotypes and play an important role in disease diagnosis and subtype classification in precision medicine.
arXiv:2506. 01486v2 Announce Type: replace Abstract: Data imbalance persists as a pervasive challenge in regression tasks, introducing bias in model performance and undermining predictive reliability.
arXiv:2505. 13518v3 Announce Type: replace-cross Abstract: Imbalanced datasets, where one class significantly outnumbers others, remain a persistent challenge in machine learning, often biasing predictions toward the majority class and degrading classifier performance.
arXiv:2606. 07141v1 Announce Type: cross Abstract: Language models trained for clinical disease inference are trained on patient data, which may include sensitive and private information, and data owners may request the removal of their data from a trained model due to privacy or copyright concerns.
arXiv:2607. 09884v1 Announce Type: cross Abstract: Multimodal medical models often degrade when inputs are missing, a common scenario in real-world clinical workflows.
The paper presents a newly curated, multi-center, multi-modal, and longitudinal lung cancer dataset comprising 1,365 patients with whole-slide images, CT scans, PET scans, structured clinical data, transcriptomics, and follow-up information. The dataset features substantial, non-uniform missingness across modalities, making it ideal for evaluating robust multi-modal fusion strategies. Benchmarks on 12‑month overall survival, disease‑specific survival, and longitudinal hazard prediction demonstrate that integrating complementary modalities consistently outperforms uni-modal approaches, even under severe missing data.
arXiv:2512. 17678v2 Announce Type: replace-cross Abstract: Selecting compact and informative gene subsets from single-cell transcriptomic data is essential for biomarker discovery, improving interpretability, and cost-effective profiling.
The paper proposes a comprehensive data generation strategy to improve deep learning performance in classifying olive tree diseases. It combines traditional augmentation, CutMix, MixUp, and DCGAN-generated synthetic images to address data scarcity and class imbalance. Experiments with EfficientNetV2B0 show significant accuracy gains across three distribution scenarios, underscoring the importance of data diversity and balance.