arXiv:2610.07694v1 Announce Type: new
Abstract: The integrative analysis of histopathological Whole-Slide Images (WSIs) and transcriptomic profiles holds significant promise for cancer survival predi...
By Tao Zhou, Ying Hu, Huazhu Fu, Yi Zhou, Xiao-Jun Wu, Haibin Ling
The paper presents a newly curated, multi-center, multi-modal, and longitudinal lung cancer dataset comprising 1,365 patients with whole-slide images, CT scans, PET scans, structured clinical data, transcriptomics, and follow-up information. The dataset features substantial, non-uniform missingness across modalities, making it ideal for evaluating robust multi-modal fusion strategies. Benchmarks on 12‑month overall survival, disease‑specific survival, and longitudinal hazard prediction demonstrate that integrating complementary modalities consistently outperforms uni-modal approaches, even under severe missing data.
By Rita Cordeiro Mendes, Maria Rita Fonseca Verdelho, Carlos Santiago, Catarina Barata
arXiv:2510.06113v2 Announce Type: replace
Abstract: Survival analysis plays a vital role in making clinical decisions. However, the models currently in use are often difficult to interpret, which red...
By Shuo Jiang, Zhuwen Chen, Liaoman Xu, Yanming Zhu, Changmiao Wang, Jiong Zhang, Feiwei Qin, Yifei Chen, Zhu Zhu
arXiv:2607. 15380v1 Announce Type: cross Abstract: Electronic health records combine free-text clinical narratives with structured measurements such as vital signs, laboratory values, and comorbidities.
By Ajay Madhavan Ravichandran, Bilgin Osmandoja, Klemens Budde, Klaus Netter, Tobias Strapatsas, Aljoscha Burchardt, Sebastian M\"oller, Roland Roller
arXiv:2607. 16260v1 Announce Type: cross Abstract: Multimodal survival analysis utilizing whole slide images (WSIs) and genomic profiles is fundamental for cancer prognosis.
By Jialong Zhong, Tingwei Liu, Baokun Yue, Jingjing Li, Yongri Piao, Miao Zhang, Leiye Liu, Jiahong Jiang, Wei Ji, Huchuan Lu
arXiv:2606. 19140v1 Announce Type: new Abstract: Accurate survival prediction is essential for personalized treatment planning in head and neck cancer, yet remains challenging due to the heterogeneous and high-dimensional nature of multimodal clinical data.
By Hugo Miccinilli, Theo Di Piazza
arXiv:2510. 17532v2 Announce Type: replace-cross Abstract: Predicting cancer treatment outcomes requires models that are both accurate and interpretable, particularly in the presence of heterogeneous clinical data.
By Raghu Vamshi Hemadri, Geetha Krishna Guruju, Kristi Topollai, Anna Ewa Choromanska
arXiv:2607. 09982v1 Announce Type: new Abstract: Electronic health record (EHR) data are inherently multimodal, and leveraging multiple modalities can improve predictive performance.
By Nikkie Hooman, Zhongjie Wu, Eric C. Larson, Mehak Gupta
arXiv:2608. 02803v1 Announce Type: cross Abstract: Attention-based multiple instance learning (ABMIL) is the predominant approach for slide-level prediction in computational pathology, yet its attention maps provide only local explanations: they indicate where a model focuses but not which histological features drive its predictions or how the model behaves across a patient cohort.
By Abdallah Lamane, Abdul Rahman Diab, Ren-Chin Wu, William Lotter
MIST is a multimodal survival prediction framework that fuses whole-slide images and genomic profiles by representing genomic features as tokens that query histology context tokens derived from a foundation model. The architecture enriches molecular information with histology context before survival prediction, avoiding late-stage merging of separately encoded modalities. Training incorporates discrete-time survival prediction, genomic feature masking, WSI dropout, and contrastive alignment, and demonstrates improved external C-index across colon, renal, lung, and glioblastoma cohorts compared to standard fusion baselines.
By Muhammet Sami Yavuz, Sabri Mustafa Kahya, Richard R. Chen, Jana Lipkova, Benedikt Wiestler
arXiv:2609.38181v1 Announce Type: new
Abstract: Survival analysis estimates time-to-event outcomes from patient covariates and is widely used for medical risk assessment. Patients seeking prognostic...
By Juan M Zambrano Chaves, Peniel Argaw, Risa Ueno, Carlo Bifulco, Kristina Young, Rom Leidner, Tristan Naumann, Hoifung Poon
arXiv:2607. 09521v1 Announce Type: new Abstract: Does every cancer patient truly need a complete diagnostic workup for accurate survival prediction?
By Chongyu Qu, Can Cui, Zhengyi Lu, Junchao Zhu, Tianyuan Yao, Junlin Guo, Juming Xiong, Yanfan Zhu, Yuechen Yang, Bennett A. Landman, Yuankai Huo