Clear cell renal cell carcinoma (CCRCC) grading is essential for treatment planning, yet existing approaches either analyze patch-level images directly or focus solely on nuclei-level classification,...
The study introduces RCC-Align, a cross‑modal contrastive learning framework that aligns paired histopathology whole‑slide images and CT scans to enhance noninvasive grading of clear cell renal cell carcinoma (ccRCC). Using patient‑level five‑fold cross‑validation on TCGA and CPTAC cohorts, RCC‑Align achieved an AUC of 0.601 and AUPRC of 0.599 for low‑ versus high‑grade ccRCC classification, outperforming CT‑only baselines and showing stronger WSI‑CT embedding alignment. The approach relies solely on CT at inference, potentially aiding grading when biopsy is unsafe or limited by tumor heterogeneity.
By Amit Das, Tanmay Shukla, Naofumi Tomita, Faraz Farhadi, Jessica Sin, Ari Hakimi, Chad Vanderbilt, Jie-Fu Chen, Ritesh Kotecha, Weijie Ma, Bing Ren, Saeed Hassanpour
arXiv:2609.26463v1 Announce Type: new
Abstract: Accurate preoperative subtype classification of renal cell carcinoma (RCC) from contrast-enhanced computed tomography remains clinically challenging. R...
By Yuan Liang, Sourav Bhattacharjee, Abraham Campbell
arXiv:2609.26578v1 Announce Type: new
Abstract: Accurate preoperative subtype classification of renal cell carcinoma (RCC) from contrast-enhanced CT remains clinically challenging because clear cell...
By Yuan Liang, Fangyijie Wang, Kathleen M. Curran, Gu\'enol\'e Silvestre, Sourav Bhattacharjee, Abraham Campbell
SCOUT is a concept‑grounded multimodal transformer that generates whole‑slide pathology reports by integrating local histological patterns, whole‑slide context, and expert‑curated diagnostic concepts. It uses evolving visual representations and recursively updated slide‑ and concept‑conditioned representations, with separate attention pathways during decoding that are fused adaptively for each token. Evaluated on TCGA‑BRCA, HistAI, and REG‑2025, SCOUT outperformed existing methods, improving BLEU, METEOR, and ROUGE‑L scores and raising the Clinical Report Quality Score on REG‑2025.
By Suryakant Singh, Saarthak Kapse, Joel Saltz, Prateek Prasanna
arXiv:2610.14151v1 Announce Type: cross
Abstract: Reliable probability estimates are important for the clinical interpretation of machine-learning classifiers, yet radiomics--image fusion models for...
By Yuan Liang, Morgan May, Abraham Campbell, Sourav Bhattacharjee, Simon Caton, Pierpaolo Dondio