The study introduces RCC-Align, a cross‑modal contrastive learning framework that aligns paired histopathology whole‑slide images and CT scans to enhance noninvasive grading of clear cell renal cell carcinoma (ccRCC). Using patient‑level five‑fold cross‑validation on TCGA and CPTAC cohorts, RCC‑Align achieved an AUC of 0.601 and AUPRC of 0.599 for low‑ versus high‑grade ccRCC classification, outperforming CT‑only baselines and showing stronger WSI‑CT embedding alignment. The approach relies solely on CT at inference, potentially aiding grading when biopsy is unsafe or limited by tumor heterogeneity.
arXiv:2609.26578v1 Announce Type: new Abstract: Accurate preoperative subtype classification of renal cell carcinoma (RCC) from contrast-enhanced CT remains clinically challenging because clear cell...
The paper introduces a semantic‑guided multimodal preprocessing technique that fuses nuclei classification maps with RGB histopathology images for Vision Transformer‑based grading of clear cell renal cell carcinoma. By concatenating classification map channels and applying multiplicative modulation, the method achieves a balanced accuracy of 0.916, markedly surpassing an RGB‑only baseline (0.707) and prior max‑voting approaches (0.427). Sensitivity analysis shows the 21‑percentage‑point improvement remains robust under simulated perturbations matching current nuclei classifier error rates, indicating effective use of imperfect nuclear‑level information.
Clear cell renal cell carcinoma (CCRCC) grading is essential for treatment planning, yet existing approaches either analyze patch-level images directly or focus solely on nuclei-level classification,...
arXiv:2609.26463v1 Announce Type: new Abstract: Accurate preoperative subtype classification of renal cell carcinoma (RCC) from contrast-enhanced computed tomography remains clinically challenging. R...
arXiv:2609.26492v1 Announce Type: new Abstract: Radiomics provides quantitative descriptions of tumour appearance that may complement disease-specific foundation models in small labelled cohorts. We...
arXiv:2606. 04365v1 Announce Type: cross Abstract: Radiology reports describe kidney lesions by type, size, enhancement, and attenuation, yet existing 3D methods predict only at the patient or organ level.
arXiv:2505. 07573v2 Announce Type: replace-cross Abstract: Renal mass segmentation has important potential to enhance the clinical workflow, especially in settings requiring quantitative assessments.
arXiv:2604.27697v2 Announce Type: replace-cross Abstract: Peritoneal metastases (PM) are staged using the surgically determined Peritoneal Cancer Index (sPCI), which requires invasive laparoscopic as...
The paper introduces the Cross‑Modal Triage Network (CMTN), a multimodal deep‑learning model that fuses a Swin Transformer V2 visual encoder with a PubMedBERT text encoder to perform severity‑based triage, pathology detection, and generate visual explanations for chest radiographs. Trained on 34,639 image‑text pairs from MIMIC‑CXR‑JPG, the CMTN achieves high ordinal agreement with reference labels (QWK = 0.9341) and excellent pathology detection (macro‑AUROC = 0.9970) while operating with 34 ms latency. However, a blinded clinical audit revealed low agreement with expert radiologists (QWK = 0.1399) and only modest spatial‑semantic concordance in heatmaps, underscoring the gap between algorithmic performance and clinical judgment.
arXiv:2606. 16991v1 Announce Type: cross Abstract: Multiphasic contrast-enhanced CT (CECT) is widely used for abdominal lesion characterization, yet it carries inherent risks of contrast-induced nephropathy, escalates acquisition burden, and heavily contributes to radiologist workload.
The study developed a multimodal ultrasound and clinical data model to predict microvascular invasion (MVI) preoperatively in hepatocellular carcinoma (HCC). Using data from 489 patients across eight centers, the model combined B-mode ultrasound, color Doppler flow imaging, dynamic contrast-enhanced ultrasound, and clinical information, achieving an AUC of 0.8953 in external validation. Dynamic contrast-enhanced ultrasound contributed the most predictive power, while other modalities and clinical data added complementary value.
FedHisto-PAST v2 is a parameter‑efficient, stain‑aware federated learning framework for cross‑site lung histopathology classification, combining a frozen HIBOU‑B foundation model with techniques such as paired‑view prediction, feature consistency, prototype learning, and adaptive aggregation. In a five‑client, non‑IID simulation and an exploratory LungHist700 cohort, the method achieved a Macro‑F1 of 0.7286 and a balanced accuracy of 0.7305, with the prediction‑level consistency component providing the most clear independent benefit. The framework updated only about 1.25% of the model parameters, demonstrating efficient adaptation while acknowledging limitations in privacy guarantees and clinical validation.