arXiv AI

Beyond Discrimination: Evaluating Probability Calibration in Radiomics-Image Fusion for Renal Cell Carcinoma Classification

arXiv Computer Vision
Sep 23

Radiomics--Foundation Fusion for Interpretable RCC Classification: Internal Benchmarking and Exploratory External Transfer

arXiv:2609.26578v1 Announce Type: new Abstract: Accurate preoperative subtype classification of renal cell carcinoma (RCC) from contrast-enhanced CT remains clinically challenging because clear cell...

By Yuan Liang, Fangyijie Wang, Kathleen M. Curran, Gu\'enol\'e Silvestre, Sourav Bhattacharjee, Abraham Campbell
arXiv AI
Sep 2

Semantic-Guided Multimodal Preprocessing for Vision Transformer-Based Clear Cell Renal Cell Carcinoma Grading

The paper introduces a semantic‑guided multimodal preprocessing technique that fuses nuclei classification maps with RGB histopathology images for Vision Transformer‑based grading of clear cell renal cell carcinoma. By concatenating classification map channels and applying multiplicative modulation, the method achieves a balanced accuracy of 0.916, markedly surpassing an RGB‑only baseline (0.707) and prior max‑voting approaches (0.427). Sensitivity analysis shows the 21‑percentage‑point improvement remains robust under simulated perturbations matching current nuclei classifier error rates, indicating effective use of imperfect nuclear‑level information.

By Fatemeh Javadian, Zhu Chen, Zahra Aminparast, Johannes Stegmaier
arXiv Machine Learning
Aug 13

Gaussian Meta-Space Augmentation for Stacking Ensembles in Multimodal IPMN Risk Stratification

arXiv:2608. 11472v1 Announce Type: cross Abstract: Pancreatic cancer is among the most lethal malignancies; risk stratification of intraductal papillary mucinous neoplasms (IPMNs) offers a crucial opportunity for early intervention but typically requires invasive tissue biopsy.

By Max A. Nelson, Eminenur Sen Tasci, Zhixiang Wang, Zongwei Zhou, Halil Ertugrul Aktas, Andrea M. Bejar, Elif Keles, Ziliang Hong, S{\i}tk{\i} Safa Taflan, Muhammed Enes Tasci, Frank H. Miller, Michael B. Wallace, Rajesh N. Keswani, Gorkem Durak, Ulas Bagci
arXiv AI
Sep 24

Cross-Modal Contrastive Learning from Histopathology and CT for Automated Renal Cell Carcinoma Grading

The study introduces RCC-Align, a cross‑modal contrastive learning framework that aligns paired histopathology whole‑slide images and CT scans to enhance noninvasive grading of clear cell renal cell carcinoma (ccRCC). Using patient‑level five‑fold cross‑validation on TCGA and CPTAC cohorts, RCC‑Align achieved an AUC of 0.601 and AUPRC of 0.599 for low‑ versus high‑grade ccRCC classification, outperforming CT‑only baselines and showing stronger WSI‑CT embedding alignment. The approach relies solely on CT at inference, potentially aiding grading when biopsy is unsafe or limited by tumor heterogeneity.

By Amit Das, Tanmay Shukla, Naofumi Tomita, Faraz Farhadi, Jessica Sin, Ari Hakimi, Chad Vanderbilt, Jie-Fu Chen, Ritesh Kotecha, Weijie Ma, Bing Ren, Saeed Hassanpour
arXiv AI
Jun 17

Probing, Fusion, and Trustworthiness: A Systematic Evaluation of Foundation Model Representations for Multimodal Cancer Analysis

arXiv:2606. 17115v1 Announce Type: cross Abstract: Foundation models (FMs) have emerged as powerful representation extractors for medical data, yet their generalizability to datasets under distribution shift remains underexplored.

By Jingyu Hu, Giuseppe Tripodi, Reed Naidoo, Sarah F. McGough, Tapabrata Chakraborti
arXiv AI
Jul 15

Calibrated Selective Prediction Using Deep Ensembles for ROI-Based Thyroid Nodule Ultrasound Classification Under Dataset Shift: A Retrospective Evaluation

arXiv:2607. 12075v1 Announce Type: cross Abstract: Background: Deep learning models can classify thyroid nodules on ultrasound, but reliable clinical decision support also requires calibrated probabilities, uncertainty estimation, and selective referral, particularly under dataset shift.

By Md. Sadibul Hasan Sadib, Md. Mohayminul Mukit, Rahmatul Kabir Rasel Sarker, Tahmid Alam Tamim, Md. Monir Hossain Shimul