arXiv:2602. 17162v3 Announce Type: replace Abstract: Genomic Foundation Models (GFMs) typically rely on Masked Language Modeling (MLM) or Next-Token Prediction (NTP) to learn the "Laws of Nature".
By Ariel Larey, Elay Dahan, Amit Bleiweiss, Raizy Kellerman, Guy Leib, Omri Nayshool, Dan Ofer, Tal Zinger, Dan Dominissini, Gideon Rechavi, Nicole Bussola, Simon Lee, Shane O'Connell, Dung Hoang, Marissa Wirth, Alexander W. Charney, Nati Daniel, Yoli Shavit
VenusGenome is a gene‑resolution masked autoencoder that learns microbial genome representations by combining visible‑only encoding with genome‑aware attention, which incorporates contig boundaries, relative strand orientations, and gene positions. The model is pretrained on over 1.7 million microbial genome assemblies using frozen protein embeddings as inputs, and its frozen representations outperform other evaluated models on nine of eleven primary metrics for both genome‑level phenotype prediction and gene‑level tasks. Ablation studies confirm the importance of genome‑aware attention and demonstrate that higher masking ratios and masked autoencoding yield better performance than BERT‑style masked modeling.
By Zhang Liang, Zhang Yukun, Tan Yang, Jiang Fan, Zhong Bozitao, Cheng Xiaoran, Hong Liang, Li Mingchen, Yu Yuanxi
arXiv:2609.14882v1 Announce Type: cross
Abstract: Nucleotide sequence analysis is central to problems spanning regulatory genomics, evolutionary biology, and phenotype prediction. Classical bioinform...
By Evgeny S. Saveliev, Krzysztof Kacprzyk, Charlotte Capitanchik, Neelanjan Mukherjee, Kate Matlin, Ryan Sheridan, Srinivas Ramachandran, Jernej Ule, David L. Bentley, Mihaela van der Schaar
arXiv:2608.07632v2 Announce Type: replace-cross
Abstract: Image-based profiling captures rich phenotypic signatures for drug discovery and functional genomics. Large public datasets like JUMP Cell Pa...
By Al\'an F. Mu\~noz, Johan Fredin Haslum, Runxi Shen, Anne E. Carpenter, Shantanu Singh
arXiv:2606. 07760v1 Announce Type: new Abstract: Understanding cellular phenotypes and how they respond to perturbations is critical for disease biology and therapeutic design.
By Alma Andersson, Aya Abdelsalam Ismail, Edward De Brouwer, Doron Haviv, Tommaso Biancalani, Kyunghyun Cho, Gabriele Scalia, A\"icha BenTaieb, Hector Corrada Bravo
arXiv:2606. 05139v1 Announce Type: new Abstract: The rapid advancement of high-throughput sequencing has led to large, high-dimensional omics datasets.
By Luca Thale-Bombien, Jan Ewald, Ralf K\"onig, Aaron Klein