Entropy, Disagreement, and the Limits of Foundation Models in Genomics
arXiv:2604. 04287v2 Announce Type: replace Abstract: Foundation models in genomics have shown mixed success compared to their counterparts in natural language processing.
arXiv:2602. 17162v3 Announce Type: replace Abstract: Genomic Foundation Models (GFMs) typically rely on Masked Language Modeling (MLM) or Next-Token Prediction (NTP) to learn the "Laws of Nature".
arXiv:2604. 04287v2 Announce Type: replace Abstract: Foundation models in genomics have shown mixed success compared to their counterparts in natural language processing.
arXiv:2606. 05173v1 Announce Type: cross Abstract: Masked language modelling (MLM) has been the dominant pre-training objective for text encoders since BERT, yet it encourages representations that are strongly anchored to surface-form token identity rather than deeper semantic structure.
arXiv:2607. 29378v1 Announce Type: cross Abstract: Large language models (LLMs) generate text by auto-regressively sampling the next token.
arXiv:2606. 15521v1 Announce Type: cross Abstract: Tokenization introduces representational redundancy: under a fixed token vocabulary, every byte string admits many valid token encodings, or segmentations, that decode to the same surface string.
arXiv:2410. 12341v4 Announce Type: replace-cross Abstract: As AI-generated content increasingly populates the web, generative AI models are at growing risk of being trained on their own outputs, a process known as AI autophagy.
arXiv:2511. 05963v4 Announce Type: replace Abstract: Transformers replace recurrence with a memory that grows with sequence length and self-attention that enables ad-hoc lookups over past tokens.
arXiv:2606. 18703v1 Announce Type: new Abstract: Pretrained biological language models expose per-token probability distributions through masked-token prediction, providing the likelihood interface central to sequence design, variant scoring, and mechanistic interpretation.
arXiv:2607. 08803v1 Announce Type: cross Abstract: The push toward large language models for biology (BioLM) has created a need for training corpora that can endow models with a genuine understanding of biology.
arXiv:2608. 06727v1 Announce Type: new Abstract: Transformer models for high-dimensional omics analysis process thousands of genes or pathways, although only a subset requires deep computation.
arXiv:2608. 14710v1 Announce Type: cross Abstract: Predicting spatial gene expression from hematoxylin and eosin (H\&E)-stained images offers a cost-effective alternative to spatial transcriptomics (ST).
arXiv:2604. 24927v2 Announce Type: replace-cross Abstract: Generating diverse responses is crucial for test-time scaling of large language models (LLMs), yet standard stochastic sampling mostly yields surface-level lexical variation, limiting semantic exploration.
arXiv:2606. 08204v1 Announce Type: new Abstract: Neural fields parameterize data as functions from coordinates to values, providing a unified framework for representation learning across modalities.