arXiv AI

SeqMaestro: From nucleotide sequences to biological hypotheses through interpretable machine learning

arXiv AI

Sep 10

Fusing Sequence Motifs and Pan-Genomic Features: Antimicrobial Resistance Prediction using an Explainable Lightweight 1D CNN-XGBoost Ensemble

arXiv:2509.23552v2 Announce Type: replace-cross Abstract: Antimicrobial Resistance (AMR) is a rapidly escalating global health crisis. While genomic sequencing enables rapid prediction of resistance...

By Md. Saiful Bari Siddiqui, Nowshin Tarannum

llms benchmarks

arXiv AI

Jun 4

You Only Train Once: Differentiable Subset Selection for Omics Data

arXiv:2512. 17678v2 Announce Type: replace-cross Abstract: Selecting compact and informative gene subsets from single-cell transcriptomic data is essential for biomarker discovery, improving interpretability, and cost-effective profiling.

By Daphn\'e Chopard, Jorge da Silva Gon\c{c}alves, Irene Cannistraci, Thomas M. Sutter, Julia E. Vogt

efficiency benchmarks safety

arXiv Machine Learning

Jul 2

Explainable AI for Cancer Drug Response Prediction: Beyond Univariate Feature Attributions

arXiv:2607. 00931v1 Announce Type: new Abstract: Predicting cancer drug response from transcriptomic profiles is a cornerstone of precision oncology, yet the scientific value of machine learning models hinges not solely on predictive accuracy, but also on their capacity to generate reliable biological insights.

By Martino Ciaperoni, Margherita Lalli, Simone Piaggesi, Martina Varisco, Francesco Carli, Riccardo Guidotti, Dino Pedreschi, Francesco Raimondi, Fosca Giannotti

arXiv Machine Learning

Jun 9

Integrating gene regulatory priors into Transformer attention with scTransformer for interpretable scRNA-seq analysis

arXiv:2606. 09558v1 Announce Type: cross Abstract: Motivation: Transformer-based models are increasingly applied to large-scale single-cell transcriptomics, showing strong performance through self-supervised learning on millions of cells.

By Mikele Milia, Louis Fabrice Tshimanga, Henning Mueller, Manfredo Atzori, Barbara Di Camillo

llms rag safety

arXiv Machine Learning

Jun 9

Biological Reasoning-Informed Regression for Interpretable Regulatory DNA Activity Prediction

arXiv:2606. 08147v1 Announce Type: cross Abstract: DNA cis-regulatory elements (CREs) such as enhancers control gene expression levels.

By Yi Duan, Zhao Yang, Jiwei Zhu, Ying Ba, Chuan Cao, Bing Su

llms reinforcement-learning benchmarks safety

arXiv Machine Learning

Jun 9

Position: Genomic Model Research Must Move Beyond Anecdotal Evaluation of Interpretability Methods

arXiv:2606. 07607v1 Announce Type: new Abstract: Advances in machine learning and computational power have unlocked the predictive potential of the human genome, yet biologists now demand that these models also elucidate the underlying biological mechanisms.

By Shasha Zhou, Mingyu Huang, Ke Li

benchmarks safety

arXiv AI

Jun 10

MedFeat: Model-Aware and Explainability-Driven Feature Engineering with LLMs for Clinical Tabular Prediction

arXiv:2603. 02221v2 Announce Type: replace-cross Abstract: In clinical tabular prediction, classical machine learning models with feature engineering often outperform neural methods.

By Zizheng Zhang, Yiming Li, Justin Xu, Jinyu Wang, Rui Wang, Lei Song, Jiang Bian, David W Eyre, Jingjing Fu

llms benchmarks safety

arXiv AI

Aug 10

bioMoR: Biology-Guided Mixture-of-Recursions for Effective Genomic Learning

arXiv:2608. 06727v1 Announce Type: new Abstract: Transformer models for high-dimensional omics analysis process thousands of genes or pathways, although only a subset requires deep computation.

By Koushik Howlader, Tirtho Roy, Md Tauhidul Islam, Wei Le

llms rag benchmarks safety

arXiv AI

Aug 12

JEPA-DNA: Grounding Genomic Foundation Models through Joint-Embedding Predictive Architectures

arXiv:2602. 17162v3 Announce Type: replace Abstract: Genomic Foundation Models (GFMs) typically rely on Masked Language Modeling (MLM) or Next-Token Prediction (NTP) to learn the "Laws of Nature".

By Ariel Larey, Elay Dahan, Amit Bleiweiss, Raizy Kellerman, Guy Leib, Omri Nayshool, Dan Ofer, Tal Zinger, Dan Dominissini, Gideon Rechavi, Nicole Bussola, Simon Lee, Shane O'Connell, Dung Hoang, Marissa Wirth, Alexander W. Charney, Nati Daniel, Yoli Shavit

rag diffusion benchmarks safety

arXiv Machine Learning

Jun 5

Symb-xMIL: Symbolic Explanations for Multiple Instance Learning in Digital Pathology

arXiv:2606. 06224v1 Announce Type: cross Abstract: Explanations of multiple instance learning (MIL) models are widely used for validation and discovery in digital histopathology.

By Yanqing Luo (Berlin Institute for the Foundations of Learning and Data, Berlin, Germany, Machine Learning Group, Technische Universit\"at Berlin, Berlin, Germany), Julius Hense (Berlin Institute for the Foundations of Learning and Data, Berlin, Germany, Machine Learning Group, Technische Universit\"at Berlin, Berlin, Germany), Niklas Preni{\ss}l (Institute of Pathology, Charit\'e Universit\"atsmedizin, Berlin, Germany, Berlin Institute of Health at Charit\'e -- Universit\"atsmedizin Berlin, BIH Biomedical Innovation Academy, BIH Charit\'e Digital Clinician Scientist Program, Berlin, Germany), Andreas Mock (Institute of Pathology, Ludwig Maximilian University of Munich, Munich, Germany, Division of Translational Medical Oncology, DKFZ, Heidelberg, Germany, NCT Heidelberg, Heidelberg, Germany, German Cancer Consortium), Klaus-Robert M\"uller (Berlin Institute for the Foundations of Learning and Data, Berlin, Germany, Machine Learning Group, Technische Universit\"at Berlin, Berlin, Germany, Department of Artificial Intelligence, Korea University, Seoul, Korea, Max-Planck Institute for Informatics, Saarbr\"ucken, Germany), Thomas Schnake (Department of Chemistry, Chemical Physics Theory Group, University of Toronto, Canada, Vector Institute for Artificial Intelligence, Toronto, Canada, Acceleration Consortium, University of Toronto, Canada), Mina Jamshidi Idaji (Berlin Institute for the Foundations of Learning and Data, Berlin, Germany, Machine Learning Group, Technische Universit\"at Berlin, Berlin, Germany)

safety

arXiv AI

Jul 7

EvoXplain: When Machine Learning Models Agree on Predictions but Disagree on Why -- Measuring Mechanistic Multiplicity Across Training Runs

arXiv:2512. 22240v5 Announce Type: replace-cross Abstract: Machine learning models are primarily judged by predictive performance, especially in applied genomics, where explanations are read as biological findings.

By Chama Bensmail

safety

arXiv AI

Jun 2

Plausibility Is Not Prediction: Contrastive Evidence for LLM-Based Cellular Perturbation Reasoning

arXiv:2606. 01042v1 Announce Type: cross Abstract: Perturbation experiments are central to understanding cellular mechanisms, but remain costly and sparse, motivating prediction of gene expression responses for unobserved conditions.

By Xinyu Yuan, Xixian Liu, Jianan Zhao, Yashi Zhang, Hongyu Guo, Jian Tang

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