A Voxel-Spacing-Aware Extension of PyRadiomics for Anisotropic Texture Analysis
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Objective: Radiomic texture features are usually computed in voxel-index neighborhoods, implicitly assuming isotropic spatial relationships. In anisotropic images, this can confound voxel geometry with interpolation-induced signal changes.
The study introduces a voxel-spacing-aware radiomic framework that incorporates physical geometry into texture computation without resampling, modifying PyRadiomics to preserve native image signals. Four extraction configurations—native non-resampled (NR), isotropic resampling (RS), voxel-spacing-aware (VS), and fake-isotropic preprocessing (FK)—were compared across 685 CT pulmonary nodules and 209 MRI breast cases, evaluating 196 radiomic descriptors. Results show that VS closely matches NR (median ICC(A,1) ≈0.998) while RS and FK exhibit lower agreement, indicating that spacing metadata alone can significantly influence radiomic features.
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RAFT-DVC is a resolution‑aware family of recurrent all‑pairs field transform (RAFT) based digital volume correlation (DVC) solvers that use encoder downsampling factors of 2, 4, and 8. The solvers localize displacement to about 0.017 feature‑grid voxels, with raw‑volume error scaling roughly as 0.017 s voxels, and exhibit complementary operating regimes determined by displacement reach and volumetric‑texture compatibility. Synthetic benchmarks show comparable performance to tuned classical DVC for fine‑texture, small‑to‑moderate displacements, while outperforming it for coarse‑texture, large‑displacement scenarios; additional tests on confocal and micro‑CT images confirm the importance of matching solver regimes to deformation magnitude and texture, and demonstrate cross‑texture transfer and improved accuracy after correcting sampler geometry.
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