EPC-3D-Diff: Equivariant Physics Consistent Conditional 3D Latent Diffusion for CBCT to CT Synthesis
Read the original on arXiv AI →The Flow has not summarised this story yet — read it at arXiv AI.
The Flow has not summarised this story yet — read it at arXiv AI.
arXiv:2509. 21913v2 Announce Type: replace-cross Abstract: Background: Cone-beam computed tomography CBCT is a commonly used modality for image guided radiotherapy.
EPC‑RawDC is a 3‑D latent diffusion model that synthesises CT images from CBCT scans by enforcing two physics‑based constraints: a geometry‑equivariant projection loss and raw data consistency using scan‑specific CBCT projections. Trained on two clinical cohorts with different scanner geometries, the method achieved SSIM of 0.97 and improved PSNR and MAE over a baseline DDPM, reducing projection and equivariant errors by 55 % and 41 % respectively.
The paper introduces a one‑pass conditional 3D rectified flow (3D Flow) framework for denoising whole‑body PET images, employing an optimized non‑uniform sampling strategy and a linear‑interpolant velocity‑matching objective. It reconstructs a full 3D volume in about 30 seconds, dramatically faster than multi‑hour 3D diffusion models, while maintaining high global image quality and lesion conspicuity even at ultra‑low doses (down to 1/100 of standard). Zero‑shot transfer tests on independent clinical data demonstrate robust performance across datasets and unseen dose levels.
arXiv:2608. 08919v1 Announce Type: cross Abstract: During standard radiotherapy planning, repeated CT acquisitions are often required for patient registration, verification, and adaptive planning, resulting in increased cumulative X-ray dose.
arXiv:2607. 11941v1 Announce Type: cross Abstract: Computed tomography (CT) is a critical imaging modality for clinical diagnosis, but reducing radiation dose inevitably introduces severe noise and structured artifacts that degrade image quality.
The paper introduces Conditional Diffusion Posterior Alignment (CDPA), a method that scales diffusion-based sparse‑view CT reconstruction to large 3D volumes by conditioning a 2D U‑Net diffusion model on an initial 3D reconstruction and enforcing data‑consistency alignment. CDPA addresses high memory demands, limited 3D training data, and slice‑wise inconsistencies, achieving state‑of‑the‑art performance on synthetic and real Cone Beam CT data. The authors also demonstrate that the same approach improves fast denoising U‑Nets, delivering near‑diffusion quality at a fraction of the computational cost.