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arXiv AI By Shadab Ahamed, Yixi Xu, Sara Kurkowska, Claire Gowdy, Joo H. O, Ingrid Bloise, Don Wilson, Patrick Martineau, Fran\c{c}ois B\'enard, Fereshteh Yousefirizi, Rahul Dodhia, Juan M. Lavista, William B. Weeks, Carlos F. Uribe, Arman Rahmim

Comprehensive framework for evaluation of deep neural networks in detection and quantification of lymphoma from PET/CT images: clinical insights, pitfalls, and observer agreement analyses

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This study presents a clinically relevant framework for evaluating deep neural networks that segment lymphoma lesions in PET/CT images, addressing gaps such as out‑of‑distribution testing and comparison with expert annotators. Using 611 multi‑institutional cases, the authors assess four networks (ResUNet, SegResNet, DynUNet, SwinUNETR) with lesion‑specific metrics, detection criteria, and metabolic‑characteristic‑based thresholds, finding that models perform best on large, intense lesions. The work also demonstrates that network errors mirror those of physicians, highlighting shared challenges with small, faint lesions.

Machine-generated by The Flow from the publisher's headline and feed description — not written or checked by a human. The full article lives at arXiv AI.

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