arXiv Machine Learning

Structural-Functional Brain Connectivity Generation via Multimodal Hypergraph-based Flow Matching

The paper introduces Multimodal Hypergraph Flow Matching (MHG‑FM), a framework that jointly generates structural connectivity (SC) and functional connectivity (FC) by constructing modality‑specific hypergraphs and learning higher‑order representations with Hypergraph Neural Network encoders. It employs Dual Cross‑Attention for bidirectional cross‑modal fusion, a variational autoencoder to map fused representations into a latent space, and conditional flow matching to synthesize connectivity and perform multimodal translation. Experiments on the Human Connectome Project Young Adult dataset demonstrate that MHG‑FM outperforms state‑of‑the‑art baselines in reconstruction quality, topology preservation, distributional similarity, and SC‑FC coupling, while achieving roughly eight times faster sampling than a comparable diffusion backbone.

arXiv AI
Jul 9

Latent graph encoding of multimodal neuroimaging features with generative AI architectures

arXiv:2607. 07027v1 Announce Type: cross Abstract: While generative models enable encoding of complex neuroimaging data for feature generation and reconstruction, developing optimal architectural frameworks with appropriate encoding and latent space processes is crucial for studying structural and functional properties of the brain.

By Ishaan Batta, Meenu Ajith, Vince Calhoun
arXiv Machine Learning
Jul 23

Geometry-Guided Generative Representation for Functional Brain Graphs

arXiv:2511. 04539v2 Announce Type: replace-cross Abstract: In network neuroscience, functional brain systems are often characterized using separate yet related graph-theoretic or spectral descriptors, overlooking how these properties covary and partially overlap across individuals and conditions.

By Subati Abulikemu, Tiago Azevedo, Michail Mamalakis, John Suckling
arXiv AI
Jun 9

NeuroAlign: Hierarchical Multimodal Fusion of Dynamic and Structural Neuroimaging for MCI Analysis

arXiv:2606. 07635v1 Announce Type: cross Abstract: Multimodal neuroimaging fusion of functional MRI (fMRI) and diffusion tensor imaging (DTI) provides complementary information for cognitive impairment analysis, but remains challenged by heterogeneous feature spaces and misaligned representations.

By Xiongri Shen, Zhenxi Song, Jiaqi wang, Yi Zhong, Leilei Zhao, Chenqi Xu, Linling Li, Yichen Wei, Lingyan Liang, Demao Deng, Luping Song, Ping Luan, Ahmed M. Anter, Shuqiang Wang, Baiying Lei, Zhiguo Zhang
arXiv Machine Learning
Sep 18

HyperAMS-Net: Adaptive Multi-Scale Spatial Hypergraph Network for Brain Disorder Classification

HyperAMS‑Net is a deep learning framework that classifies brain disorders from resting‑state fMRI or structural MRI data. It combines adaptive multi‑scale convolution, hypergraph attention, spatial‑channel attention, and adaptive feature fusion to capture complementary patterns across multiple scales and higher‑order dependencies. Evaluated on ABIDE, REST‑meta‑MDD, and ADNI datasets, it achieves state‑of‑the‑art accuracy and AUC, with ablation studies showing hypergraph attention as the most critical component.

By Proloy Kumar Mondal, Md Kamran Hussin Chowdhury, Hoi Leong Lee
arXiv Machine Learning
Jun 25

SDE-Driven Spatio-Temporal Hypergraph Neural Networks for Irregular Longitudinal fMRI Connectome Modeling in Alzheimer's Disease

arXiv:2603. 20452v2 Announce Type: replace Abstract: Longitudinal neuroimaging is essential for modeling disease progression in Alzheimer's disease (AD), yet irregular sampling and missing visits pose substantial challenges for learning reliable temporal representations.

By Ruiying Chen, Yutong Wang, Houliang Zhou, Wei Liang, Yong Chen, Lifang He
arXiv Machine Learning
Sep 29

Supervised Deep Multimodal Matrix Factorization for Interpretable Brain Network Analysis

The paper introduces Supervised Deep Multimodal Matrix Factorization (SD3MF), an interpretable framework that extends Symmetric Nonnegative Matrix Tri-Factorization to supervised prediction across populations of multimodal brain graphs. SD3MF learns deep hierarchical factorizations for each modality and a shared latent representation, jointly optimizing graph reconstruction and prediction while enabling data-driven multimodal fusion. Experiments on multimodal connectome datasets demonstrate that SD3MF outperforms strong deep learning baselines such as CNNs and GNNs, providing biologically interpretable insights through community-level interaction matrices.

By Amjad Seyedi, Lifang He, Songlin Zhao, Akwum Onwunta, Nicolas Gillis
arXiv Machine Learning
Jul 20

Toward Federated Multimodal Graph Foundation Models: A Topology-Aware Multimodal Alignment Framework

arXiv:2607. 15687v1 Announce Type: new Abstract: Multimodal-attributed graphs (MAGs), whose nodes carry modalities such as images and text alongside topological structure, now pervade applications including social platforms, e-commerce, and biomedical networks, offering richer semantic signals than single-modality graphs.

By Xunkai Li, Guohao Fu, Yuming Ai, Zhengyu Wu, Hongchao Qin, Rong-Hua Li, Guoren Wang