The paper introduces MSR-IVA, a state-aware fusion method that combines a shared structural representation with state‑specific residual adaptations and masks for incomplete state expression. Applied to an Alzheimer’s Disease Neuroimaging Initiative cohort, MSR-IVA increased matched source coupling by 6.5% and decreased unmatched dependence by 15.7% compared to a baseline IVA approach. For subjects expressing both states, the method achieved a mean absolute cross‑state structural source correlation of 0.9177, far higher than the 0.2978 obtained without sharing, indicating effective preservation of source correspondence while allowing state‑specific adaptation.
By Victor Solomon, Zening Fu, Rafal Angryk, Vince D. Calhoun, Jingyu Liu
The paper introduces Neuro‑JEPA, a sparse multimodal foundation model that learns unified representations of brain MRI across T1w, T2w, and FLAIR sequences using a latent predictive objective and a Mixture‑of‑Experts architecture. It was pretrained on over 1.5 million scans from 428,647 studies and systematically evaluates architectural, masking, objective, and sparsity choices for robust multimodal representation learning. Across 47 tasks from three health systems and 12 public datasets, Neuro‑JEPA consistently outperforms a simple CNN baseline, demonstrating its effectiveness for both clinical and research applications.
By Haoxu Huang, Long Chen, Jingyun Chen, Jinu Hyun, James Ryan Loftus, Kara Melmed, Daniel Orringer, Jennifer Frontera, Seena Dehkharghani, Arjun Masurkar, Narges Razavian
arXiv:2607. 07027v1 Announce Type: cross Abstract: While generative models enable encoding of complex neuroimaging data for feature generation and reconstruction, developing optimal architectural frameworks with appropriate encoding and latent space processes is crucial for studying structural and functional properties of the brain.
By Ishaan Batta, Meenu Ajith, Vince Calhoun
arXiv:2512. 10966v3 Announce Type: replace-cross Abstract: Accurate and early diagnosis of Alzheimer's disease (AD) is critical for effective intervention and requires integrating complementary information from multimodal neuroimaging data.
By Farica Zhuang, Shu Yang, Dinara Aliyeva, Zixuan Wen, Duy Duong-Tran, Christos Davatzikos, Tianlong Chen, Song Wang, Li Shen
arXiv:2608. 07393v1 Announce Type: new Abstract: Functional Magnetic Resonance Imaging ( fMRI ) data are often pooled into collaborative multi-site consortia, as deep learning models for analyses require large datasets to generalize well.
By Deepank Girish, Yi Hao Chan, Yubin Zheng, Sukrit Gupta, Jagath C. Rajapakse
arXiv:2607. 09788v1 Announce Type: cross Abstract: Alzheimer's disease (AD) is a common neurodegenerative disorder, and early diagnosis is of great significance for delaying disease progression and enabling timely intervention.
By Ni Yao, Zhenxu Wang, Danyang Sun, Chuang Han, Yanting Li, Jiaofen Nan, Fubao Zhu, Chen Zhao, Weihua Zhou