CoMLP introduces a cooperatively-gated MLP module that fuses multimodal medical data—such as imaging modalities and clinical reports—without relying on computationally heavy cross-attention. The module uses regional and dilated MLP interactions to capture both local and global cross-modal dependencies, enabling fine-grained fusion at high spatial resolutions. Experiments on five segmentation benchmarks, covering 2D/3D images and diverse anatomical regions, show consistent improvements over state-of-the-art multi-modal and language-guided methods, highlighting the effectiveness of MLP-based interaction for medical image segmentation.
By Mingyuan Meng, Shuchang Ye, Mingjian Li, Zhenyu Zhao, Jinman Kim, Lei Bi
BiCLIP is a bidirectional multimodal framework that enhances medical image segmentation by allowing visual features to iteratively refine textual representations, improving semantic alignment. It incorporates an augmentation consistency objective to stabilize learning against perturbed inputs. Experiments on QaTa-COV19 and MosMedData+ show that BiCLIP outperforms state‑of‑the‑art image‑only and multimodal baselines, achieving strong performance even with only 1% labeled data and resisting common clinical artifacts such as motion blur and low‑dose CT noise.
By Saivan Talaei, Fatemeh Daneshfar, Abdulhady Abas Abdullah, Mourad Oussalah
arXiv:2608. 13690v1 Announce Type: cross Abstract: Medical image segmentation is still largely treated as a vision-only problem, although clinical interpretation often relies on textual knowledge of anatomy, location, appearance, and surrounding context.
By Rafi Ibn Sultan, Hui Zhu, Chengyin Li, Dongxiao Zhu
arXiv:2505.03380v2 Announce Type: replace
Abstract: Accurate delineation of tumors and surrounding organs-at-risk is essential for radiotherapy, surgery and treatment response assessment, yet remains...
By Haonan Wang, Jiaji Mao, Lehan Wang, Qixiang Zhang, Marawan Elbatel, Yi Qin, Huijun Hu, Baoxun Li, Wenhui Deng, Weifeng Qin, Hongrui Li, Jialin Liang, Jun Shen, Xiaomeng Li
The paper investigates how much clinical text influences pixel‑level predictions in multimodal medical image segmentation. It shows that segmentation performance is largely insensitive to the choice of fusion module, but that the impact of text varies across datasets: removing text severely degrades performance on BUSI and BTMRI, while it has only a marginal effect on ISIC and Kvasir‑SEG. Using an Evidence Decoupling Decoder, the authors reveal that text mainly modulates global semantic context rather than spatial localization, and that the specific semantic components driving sensitivity differ by dataset.
By Ziquan Liu, Zhewei Zhu, Xuyang Shi
arXiv:2607. 09481v1 Announce Type: cross Abstract: Text-guided medical image segmentation leverages clinical semantics to improve lesion delineation, yet many existing models bind cross-modal fusion, supervision, and decoder design into a task-specific architecture.
By Yungeng Liu, Xuanzi Fang, Haijin Zeng, Qi Dai, Yongyong Chen
arXiv:2601.06847v2 Announce Type: replace-cross
Abstract: Vision-Language Models (VLMs) can generate convincing clinical narratives, yet frequently struggle to visually ground their statements. We po...
By Mengmeng Zhang, Xiaoping Wu, Hao Luo, Fan Wang, Yisheng Lv
SEG-SAM is a unified medical image segmentation model that builds on the Segment Anything Model (SAM) by integrating semantic medical knowledge. It introduces a semantic‑aware decoder separate from SAM’s original decoder to handle both semantic segmentation of prompted objects and classification of unprompted objects. The model also incorporates key medical category characteristics from large language models via a text‑to‑vision semantic module and uses a cross‑mask spatial alignment strategy to improve overlap between predictions, achieving superior performance over existing SAM‑based and task‑specific methods.
By Shuangping Huang, Hao Liang, Qingfeng Wang, Chulong Zhong, Zijian Zhou, Miaojing Shi
Textual descriptions can reduce ambiguity in medical image segmentation by specifying the finding and location to be delineated. Existing text-guided methods mainly improve where image and language fe...
Instance-Guided Report Anchoring (IGRA) is a model-agnostic module that links each abnormality instance in a chest CT to the corresponding finding in a radiology report during training, while discarding text components at inference. By reformulating free-text grounding as multi-label volumetric segmentation, IGRA allows all abnormality categories to be predicted in a single image-only forward pass. The method improves Dice scores by 22.5% over the strongest image-only baseline and matches state‑of‑the‑art performance on single-finding subsets, with consistent gains across multiple 3D segmentation backbones and datasets.
By Zhenyu Bu, Haoyan Ding, Chushu Shen, Xinyuan Zheng, Peiyu Duan, Xueqi Guo, Sepehr Farhand, Yoshihisa Shinagawa, Gerardo Hermosillo, Chaowei Wu
Multimodal Routing and Region Refinement for Language-Guided Medical Image Segmentation (MRSeg) is a parameter‑efficient framework that uses frozen ConvNeXt‑Tiny and PubMedBERT encoders to extract multiscale visual features and clinical text tokens. A joint router predicts a sparse mixture over low‑rank adapter bases, enabling separate adaptation for two visual scales and text while keeping feature‑specific parameters distinct. Region Bridge aggregates dense visual tokens into latent regions using text‑derived queries, refines them via self‑attention and text cross‑attention, and redistributes the refined information back to the feature maps, culminating in a multiscale decoder that combines refined semantic features with shallow image evidence. MRSeg achieves state‑of‑the‑art Dice/mIoU scores on QaTa‑COV19 and MosMedData+ with only 7.11 M trainable parameters and 7.60 GFLOPs.
By Md Maklachur Rahman, Md Hasan Al Banna, Saraf Anjum, Assame Arnob, Tracy Hammond
Multimodal large language models (MLLMs) hold immense potential to revolutionize clinical practice, yet deploying them in the medical domain is fundamentally a vision-centric challenge: models must absorb knowledge from heterogeneous 2D and 3D medical images, and evaluation protocols must align with radiologists' clinical practice and provide an accurate, fine-grained and factualness-driven assessment. In this paper, we introduce ClinFusion, a vision-centric MLLM designed for holistic medical understanding that systematically addresses these limitations.