The paper presents a Time-Aware transformer-based model designed to predict Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD) using only respiratory data from daily-use ventilators. By capturing symptom patterns and their temporal progression, the model generates meaningful patient representations and outperforms traditional methods across multiple classification tasks. This approach aims to provide timely detection of AECOPD while minimizing latency associated with clinical and laboratory data.
By Weihao Qu, Ling Zheng, Dongyang Wang, Jiacun Wang, Haowen Pan
INTERVenE introduces Transformer models that use a knowledge‑based temporal abstraction (KBTA) token stream of named clinical concepts instead of raw measurements, enabling per‑token attributions to resolve directly to clinical concepts. Two variants are offered: an auto‑regressive decoder that generates future abstraction trajectories with step‑wise risk readouts, and a bidirectional encoder that jointly predicts risk and time‑to‑event in a single pass. On 57,078 MIMIC‑IV admissions, the encoder variant outperforms neural baselines with a support‑weighted AUPRC of 0.672 and AUROC of 0.901, while the decoder provides complementary token‑level risk trajectories.
By Shahar Oded, Yuval Shahar
arXiv:2602. 00541v2 Announce Type: replace Abstract: Clinical events captured in Electronic Health Records (EHR) are irregularly sampled and may consist of a mixture of discrete events and numerical measurements, such as laboratory values or treatment dosages.
By Zilin Jing, Vincent Jeanselme, Yuta Kobayashi, Simon A. Lee, Chao Pang, Aparajita Kashyap, Yanwei Li, Xinzhuo Jiang, Shalmali Joshi
arXiv:2605. 11130v4 Announce Type: replace-cross Abstract: Critical events in multivariate time series, from turbine failures to cardiac arrhythmias, demand accurate prediction, yet labeled data is scarce because such events are rare and costly to annotate.
By Jonas Petersen, Gian-Alessandro Lombardi, Riccardo Maggioni, Camilla Mazzoleni, Federico Martelli, Philipp Petersen
Mr.Dec is a new Transformer‑decoder model that predicts 30‑day hospital readmission by treating each admission as a chronological sequence of daily multimodal events, integrating Electronic Health Record updates and Chest X‑ray findings. It uses disease‑specific supervised contrastive learning to shape a diagnosis‑aware latent space and preserves day‑level clinical signals that other methods often compress. Experiments on MIMIC‑IV and MIMIC‑CXR datasets show state‑of‑the‑art performance and the model can highlight "Critical Days" for actionable real‑time risk stratification.
By Minjun Kim, Jong Hak Moon
PGP-Clinical-TimeKAN is a trajectory-first framework for joint probabilistic forecasting of multivariate physiological data, combining missingness-aware temporal encoders, a soft organ-system prior, patient-specific relations, nonlinear Kolmogorov‑Arnold messages, and a low‑rank multivariate Student‑t head. Evaluated on a MIMIC‑IV cohort of 6,882 patients, it achieves the second‑lowest normalized MAE and the lowest RMSE among 13 models, while providing calibrated probabilistic forecasts with empirical coverage at 50%, 80%, and 95% intervals. Ablation studies show that relational structure is critical for performance, and increasing covariance rank improves likelihood but not point accuracy.
whyItMatters":"The model demonstrates that joint trajectory forecasting can yield highly accurate, calibrated predictions of physiological trajectories, offering a potentially inspectable intermediate task for clinical deterioration prediction."
By Weizhi Nie, Rihao Chang, Weijie Wang, Yuting Su
arXiv:2607. 23412v1 Announce Type: new Abstract: Electrocardiograms (ECGs) are widely used for cardiovascular risk prediction, yet models often fail to transfer across hospitals because of protocol, population, and measurement differences.
By Jie Lin, Weijie Sun, Sunil V. Kalmady, Anita Khalafbeigi, Abram Hindle, Padma Kaul, Russell Greiner
arXiv:2511. 16839v4 Announce Type: replace-cross Abstract: Purpose: Heart failure (HF) discharge planning depends on identifying patients at risk of deterioration or death, yet accurate prediction from routinely collected electronic health records (EHRs) remains challenging.
By Falk Dippel, Yinan Yu, Annika Rosengren, Martin Lindgren, Christina E. Lundberg, Erik Aerts, Martin Adiels, Helen Sj\"oland
arXiv:2608.29301v1 Announce Type: new
Abstract: Predicting future organ dysfunction in Intensive Care Unit (ICU) patients is critical for early clinical intervention, yet existing machine learning ap...
By Razan Albouq, Asra Aslam
arXiv:2608.29419v1 Announce Type: cross
Abstract: Deep learning architectures are increasingly proposed for patient trajectory modeling in electronic health records (EHRs), yet their advantage over s...
By Asra Aslam, Volodymyr Chapman, Maurice M. O'Connell, Aseel S. Abuzour, Michael Abaho, Danushka Bollegala, Gary Leeming, Eduard Shantsila, Andrew Clegg, Lauren E. Walker, Iain Edward Buchan, Samuel D. Relton
Random Hazard Forests (RHF) is a survival tree ensemble that models how a patient's hazard changes over continuous time as new measurements arrive. RHF directly estimates a nonparametric hazard likelihood for predictable covariate processes, using an efficient working model to guide tree construction and then estimating flexible time‑varying hazards at each terminal node. By routing each tree based on the covariate state immediately before each time point, RHF can handle irregular and asynchronous covariate updates, and averaging across trees yields a pathwise hazard estimate that accurately captures changing risk in simulations and an intensive‑care application.
By Hemant Ishwaran, Eileen M. Hsich, Udaya B. Kogalur, Donald K. K. Lee
arXiv:2606. 10725v1 Announce Type: new Abstract: Background.
By Olga Shakhmatova, Dmitrii Kriukov, Daniil Larionov, Nikita Khromov, Iaroslav Bespalov, Alexander Zolotarev, Kirill Grishchenkov, Ekaterina Ivanova, Miron Kuznetsov, Ilya Sochenkov, Elizaveta Panchenko, Artem Shelmanov, Dmitry V. Dylov