This study develops a rolling day‑wise mortality prediction model for critically ill patients with acute kidney injury on continuous renal replacement therapy (CRRT) by incorporating minute‑level machine pressure waveforms alongside electronic health record (EHR) data. After cleaning the raw machine data—aligning it with therapy intervals, removing priming and downtime minutes, and denoising artifacts—the authors trained a transformer‑based stacked ensemble that fuses a sequence transformer with classical models using circuit‑instability features and clinical variables. In a multi‑center benchmark of 976 patients, the combined model achieved a one‑day mortality AUROC of 0.766, outperforming machine‑only (0.625) and EHR‑only (0.717) models, and SHAP analysis highlighted key pressure‑related features such as filter pressure, transmembrane pressure, and access‑to‑return difference. whyItMatters":"By integrating previously discarded CRRT machine data, the study provides a continuous, real‑time risk signal that could enable earlier detection of patient deterioration and improve mortality prediction in a high‑risk population."
arXiv:2511. 16839v4 Announce Type: replace-cross Abstract: Purpose: Heart failure (HF) discharge planning depends on identifying patients at risk of deterioration or death, yet accurate prediction from routinely collected electronic health records (EHRs) remains challenging.
The paper presents a hybrid Transformer framework that estimates non‑invasive continuous blood pressure from ECG/PPG‑derived feature sequences. It models 10‑step sequences of six physiological descriptors and two demographic covariates, combining Transformer, Kolmogorov‑Arnold Network, and XGBoost modules, and uses a dynamic fusion decoder to predict diastolic and systolic BP. On a large MIMIC‑III dataset, the model achieved mean errors of 0.41 mmHg (diastolic) and –1.60 mmHg (systolic) with high accuracy within 10 mmHg for most predictions.
arXiv:2608.29301v1 Announce Type: new Abstract: Predicting future organ dysfunction in Intensive Care Unit (ICU) patients is critical for early clinical intervention, yet existing machine learning ap...
The study introduces SynerT, a waveform-only hybrid temporal model that uses a causal dilated TCN and dilated recurrent layers to predict early intraoperative acute kidney injury (AKI). Two extensions, SynerT-MM and SynerT-Stack, incorporate hemodynamic summaries, preoperative covariates, and a leakage-safe stacked ensemble to improve discrimination and calibration. Evaluated on the VitalDB database with a strict 60‑minute prediction window, SynerT-Stack achieved the best performance across AUROC, AUPRC, and F1‑max, and demonstrated the greatest net clinical benefit after recalibration.
arXiv:2608. 19578v1 Announce Type: new Abstract: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) can worsen rapidly, making timely prediction a clinical priority.
arXiv:2511. 02340v3 Announce Type: replace Abstract: Chronic Kidney Disease (CKD) affects nearly 10\% of the global population and often progresses to end-stage renal failure.
The paper introduces NECA, a model‑agnostic augmentation technique that retrieves similar patients from the training set and transforms their organ‑dysfunction event onset times into cumulative event‑curve features for multiple future horizons (6h, 12h, 24h, 42h). These features are concatenated with the original patient representation and fed to standard downstream predictors, leading to improved PR‑AUC and ROC‑AUC on PhysioNet 2012 and a MIMIC‑IV subset across several organ‑dysfunction tasks. Ablation studies show that clinically meaningful retrieval and horizon‑specific neighbor risk are the main drivers of performance gains, especially for neurological dysfunction events.
arXiv:2607. 23412v1 Announce Type: new Abstract: Electrocardiograms (ECGs) are widely used for cardiovascular risk prediction, yet models often fail to transfer across hospitals because of protocol, population, and measurement differences.
arXiv:2608. 02663v1 Announce Type: cross Abstract: Accurate ICU mortality prediction requires modeling irregular clinical observations across heterogeneous entity types.
The study examined how physiological trajectories and observation patterns influence ICU mortality prediction across different datasets (MIMIC‑III, MIMIC‑IV, eICU). Models incorporating longitudinal physiological summaries (R2) consistently improved external prediction, while observation‑pattern features (R3) mainly benefited locally developed models and were highly sensitive to measurement timing and availability. The findings highlight that the transportability of clinical prediction models depends not only on patient populations but also on the conditions under which measurements are collected.
arXiv:2501. 16388v3 Announce Type: replace Abstract: Background: Chronic kidney disease (CKD), a progressive disease with high morbidity and mortality, has become a significant global public health problem.
An Intraoperative Hypotension (IOH) event is a frequent complication during administration of general anaesthesia with serious downstream consequences, yet clinical management remains reactive and not...