arXiv AI

Towards Accurate and Lightweight Peripheral Neuroblastic Tumor Diagnosis via Contrastive Multi-scale Pathological Image Analysis

The paper introduces CoPath, a lightweight framework for diagnosing peripheral neuroblastic tumors (pNTs) from whole-slide images. CoPath combines CoHisNet, a multi‑scale feature‑fusion network that replaces traditional MLPs with Kolmogorov‑Arnold Network layers for efficient nonlinear modeling, and PathVote, which aggregates patch‑level predictions using pathology‑informed priors. Experiments on a private pNT cohort and the public BreakHis dataset show that CoPath matches or surpasses existing classifiers while reducing computational complexity.

arXiv AI
Jun 8

DaX: Learning General Pathology Representations Across Scales

arXiv:2606. 06983v1 Announce Type: cross Abstract: Computational pathology requires visual representations that transfer across diverse clinical endpoints and remain robust to variation in magnification, staining, scanner type, slide preparation, and input resolution.

By Bokai Zhao, Yiyang Zhang, Long Bai, Tai Ma, Hanqing Chao, Minfeng Xu
arXiv AI
Jul 7

Semantic Segmentation-Driven Image-Level Diagnosis of Liver Cancers in Hematoxylin and Eosin Histopathology Images

arXiv:2607. 03253v1 Announce Type: cross Abstract: As hematoxylin & eosin (H&E) staining constitutes the primary entry point in routine diagnostic workflows, computer-aided diagnosis from whole-slide H&E images is of particular clinical relevance.

By Ivica Kopriva, Dario Sitnik, Arijana Pacic, Karolina Krstanac, Irena Veliki Dalic, Marijana Popovic Hadzija
arXiv AI
Jun 30

Data-Efficient Multimodal Alignment for Histopathology-based Molecular Prediction

arXiv:2606. 29949v1 Announce Type: cross Abstract: H&E-stained whole-slide images offer cohort-scale availability and rich spatial context but lack molecular specificity, whereas bulk RNA-seq provides transcriptome-wide resolution at high cost with limited archival availability.

By Dominik Winter, Dominik Vonficht, Lo\"ic Le Bescond, Christian Gebbe, Marco Rosati, Richard J. Chen, Markus Schick, Ross Stewart, Nicolas Brieu
arXiv AI
Jun 8

Mitosis Detection in the Wild: Multi-Tumor and Context-Aware Generalization in the MIDOG 2025 Challenge

arXiv:2606. 07368v1 Announce Type: cross Abstract: Automated mitosis detection is a well-established task in computational pathology.

By Marc Aubreville, Jonas Ammeling, Sweta Banerjee, Viktoria Weiss, Taryn A. Donovan, Robert Klopfleisch, Jiaqi Lv, Shan E Ahmed Raza, Rapha\"el Bourgade, Thomas Walter, Yasemin Topuz, Song\"ul Varl{\i}, Charles-Antoine Collins-Fekete, Zhuoyan Shen, Navya Sri Kelam, Nitin Singhal, Christian Marzahl, Brian Napora, Tengyou Xu, Hongyan Gu, Mario Vento, Gennaro Percannella, Norbert Ropiak, Izabela Wasiak, Jie Xiao, Shaojun Liu, Seungho Choe, April Khademi, Vidushi Walia, Sujatha Kotte, Andrew Broad, Alex Wright, Guillaume Balezo, Esha Sadia Nasir, Mostafa Jahanifar, Yosuke Yamagishi, Shouhei Hanaoka, Mattia Sarno, Francesco Tortorella, Biwen Meng, Jingxin Liu, Sara Krauss, Daniel Hieber, Lavish Ramchandani, Dev Kumar Das, Mieko Ochi, Yuan Bae, Piotr Giedziun, Mateusz Maniewski, Vangala Govindakrishnan Saipradeep, Naveen Sivadasan, Leire Benito-Del-Valle, Adrian Galdran, Kaustubh Atey, Sameer Anand Jha, Adinath Dukre, Imran Razzak, Maxime W. Lafarge, Viktor H. Koelzer, Nils Porsche, Nikolas Stathonikos, Mitko Veta, Dominik Hirling, Zsanett Zs\'ofia Iv\'an, Peter Horvath, Katharina Breininger, Christof A. Bertram
arXiv AI
Jul 21

GigaPath-Flash and GigaTIME-Flash: Efficient Pathology Foundation Models for Whole-Slide and Tumor Microenvironment Analysis

arXiv:2607. 18218v1 Announce Type: cross Abstract: Foundation models have emerged as a driving force in computational pathology, with the potential to transform cancer diagnosis, prognosis, and treatment selection by learning transferable representations from large-scale histopathology data.

By Naoto Usuyama, Jeya Maria Jose Valanarasu, Sicong Yao, Hanwen Xu, Jaspreet Bagga, Guanghui Qin, Robert E. Kramer, Cliff Wong, Soohee Lee, Hao Qiu, Theodore Zhengde Zhao, Racheli Ben Shimol, Angela Crabtree, Kevin Matlock, Eduardo Alejandro Lozano Garcia, Naiteek Sangani, Alberto Santamaria-Pang, Jason Entenmann, Alexandra Q. Bartlett, Bill J. Wright, Bernard A. Fox, Brian Piening, Sheng Zhang, Sheng Wang, Tristan Naumann, Carlo Bifulco, Hoifung Poon
arXiv Computer Vision
Aug 26

EMFE: A lightweight, explainable machine learning framework for malaria cell classification

EMFE (Efficient Mathematical Feature Extraction) is a lightweight, explainable machine‑learning framework that classifies single red‑blood‑cell images as parasitized or uninfected using five engineered features: Gray World color normalization, adaptive green‑channel thresholding, morphological spot detection, and classical classifiers. On the NIH LHNCBC malaria dataset (27,558 images from 200 patients), a tuned Random Forest achieved 94.6% pooled out‑of‑fold accuracy, 94.3% on a 40‑patient holdout, and outperformed deep‑learning baselines in an accuracy‑efficiency trade‑off. Ablation studies, synthetic perturbations, and explainability analyses identified spot saturation as the dominant discriminative feature and quantified the framework’s failure modes and patient‑level performance.

By Md Abdullah Al Kafi, Walayat Hussain, Mousumi Karmakar, Sumit Kumar Banshal, Ahmed Al Marouf