EXPOSE is a framework that applies Sparse Autoencoders to Vision Foundation Model embeddings in computational pathology, aiming to separate biological signals from domain‑specific noise. By training a sparse representation of VFM features and using a linear classifier to flag domain‑specific latent dimensions, the method masks these components before downstream relapse prediction, avoiding the need to retrain the backbone model. Experiments on a large prostate cancer dataset demonstrate that removing domain‑specific features improves cross‑domain performance and raises the Domain Robustness Index (DoRI).
arXiv:2601.17228v2 Announce Type: replace Abstract: Deep learning models in computational pathology often fail to generalize across cohorts and institutions due to domain shift. Existing approaches e...
HERO (Histology Encoder for Robust Representation in Oncology) is a ViT‑G/14 pathology foundation model trained with DINO and iBOT objectives and refined using high‑resolution Gram anchoring on a 500‑million‑tile corpus from about 575,000 clinical whole‑slide images. It demonstrates superior robustness to center, scanner, and stain variation compared to other state‑of‑the‑art foundation models, while maintaining competitive performance on tile‑level classification, segmentation, and gene‑expression prediction. Across 39 slide‑level clinical tasks, HERO ranks first on average and achieves the best average rank across six benchmark frameworks under an equal‑weighted analysis.
arXiv:2606. 07646v1 Announce Type: cross Abstract: Test-time adaptation (TTA) aims to align a model to shifting test domains using only unlabeled streaming data.
arXiv:2602. 12542v2 Announce Type: replace-cross Abstract: Deep learning models for clinical event prediction on electronic health records (EHR) often suffer performance degradation when deployed under different data distributions.
arXiv:2608. 10131v1 Announce Type: cross Abstract: Vision foundation models are increasingly used as reusable encoders in medical image computing, yet their high-dimensional spatial embeddings are difficult to inspect beyond downstream task performance or global dimensionality reduction.
arXiv:2608. 05960v1 Announce Type: cross Abstract: Routine CT interpretation is inherently comprehensive, capturing incidental findings across the entire scan volume.
arXiv:2607. 25497v2 Announce Type: replace-cross Abstract: Pathology foundation models encode non-biological variation introduced by tissue preparation, staining and scanning, enabling shortcut learning that undermines generalisation across institutions.
arXiv:2606. 16196v1 Announce Type: new Abstract: Deep neural networks have achieved remarkable performance across medical imaging tasks, yet their tendency to overgeneralize under distributional shifts poses a major obstacle to safe clinical deployment.
arXiv:2512. 21414v2 Announce Type: replace-cross Abstract: Recent tool-use frameworks powered by vision-language models (VLMs) improve image understanding by grounding model predictions with specialized tools.
arXiv:2606. 03553v1 Announce Type: cross Abstract: While principal component analysis (PCA) is a fundamental tool for dimensionality reduction, its dense representations make it ill-suited for high-dimensional data.
arXiv:2607. 08605v1 Announce Type: cross Abstract: Sparse autoencoders (SAEs) have emerged as a promising technique for mechanistic interpretability by learning a set of sparse latent features in large models, each of which encodes a distinct concept.
arXiv:2606. 06696v1 Announce Type: cross Abstract: Vision and language models (VLMs) hold immense promise to transform biomedical imaging workflows, from detecting lesions in chest X-rays to profiling cellular features in microscopy.