BrainPFN is a Prior Data Fitted Network that predicts behavioral phenotypes from functional MRI data without needing per-score or per-cohort refitting. It is meta-trained on a domain-specific prior derived from about 7,000 real functional connectivity matrices, generating one billion synthetic training samples. In tests across four independent cohorts, BrainPFN outperforms Kernel Ridge Regression on small-sample predictions and rivals larger foundation models, all while using a modest, publicly available training pool.
arXiv:2609.37642v1 Announce Type: new Abstract: Self-supervised pretraining reshaped prediction in language and vision, and brain foundation models (BFMs) inherited its promise. Representations learn...
arXiv:2608.30418v1 Announce Type: cross Abstract: Resting-state functional magnetic resonance imaging (rs-fMRI) functional connectivity (FC) matrices are widely used for individual-level prediction,...
BrainFedFM is a structural brain MRI foundation model that was federatively pretrained on 164,707 3‑D scans from 42 sites using a dual‑priority approach that emphasizes informative anatomical regions locally and prioritizes site contributions globally. The model outperformed seven baseline models—including four centralized foundation models—across 20 downstream tasks (classification, regression, segmentation), achieving a mean rank of 1.68 and a 50% performance gain, especially in classification and regression and among underrepresented populations. These results demonstrate the model’s generalizability and show that federated pretraining can effectively develop neuroimaging foundation models without pooling raw images.
arXiv:2606. 02228v1 Announce Type: cross Abstract: Predicting whether an individual with Alzheimer's disease will experience mild or severe disease progression is essential for personalized treatment.
arXiv:2609.23983v1 Announce Type: new Abstract: Neuroimaging foundation models pretrained on large, predominantly western cohorts are increasingly proposed as general-purpose backbones for brain MRI...
arXiv:2506.15626v3 Announce Type: replace-cross Abstract: $\textbf{Objective:}$ Brain-predicted age difference (BrainAGE) is a neuroimaging biomarker reflecting brain health. However, training robust...
arXiv:2604. 27277v3 Announce Type: replace-cross Abstract: Brain MRI underpins a wide range of neuroscientific and clinical applications, yet most learning-based methods remain task-specific and require substantial labeled data.
BrainATCL is an unsupervised, nonparametric framework that learns adaptive temporal brain connectivity from resting‑state fMRI data. It dynamically adjusts the lookback window for each snapshot based on newly added edges and encodes graph sequences with a GINE‑Mamba2 backbone, incorporating brain‑structure and function‑informed edge attributes. The method is evaluated on functional link prediction and age estimation, showing superior performance and strong generalization, even across sessions.
The paper investigates combining a domain‑specific self‑supervised task—voxel‑level brain age prediction—with a general task—image inpainting—to pretrain models for brain MRI segmentation. A multitask pretraining framework jointly optimizes both objectives, yielding representations that outperform single‑task pretraining and training from scratch on three segmentation benchmarks (multiple sclerosis lesions, ischemic stroke lesions, and cortical structures). The study demonstrates that integrating domain‑specific and general self‑supervised tasks benefits the development of generalizable neuroimaging foundation models.
arXiv:2606. 04010v1 Announce Type: cross Abstract: Brain foundation models (BFMs) are self-supervised Transformers pretrained on fMRI data.
The paper introduces Explainable Graph-theoretical Machine Learning (XGML) to build individual metabolic brain graphs from FDG-PET data and identify subgraphs predictive of multivariate Alzheimer’s disease outcomes. Using ADNI data, the best model—kernel density estimation with Hellinger distance and random forest—achieved a Pearson correlation of 0.595 across eight cognitive scores, with the highest performance on ADAS13, ADAS11, and ADASQ4. Key edges were found to be jointly but differentially predictive, indicating potential network biomarkers for cognitive decline, though external validation on OASIS3 showed weaker performance likely due to cohort differences.
The study assesses how reliably individualized functional‑network attribution can be derived from resting‑state fMRI data for predicting cognitive scores in the ADNI cohort. Using a frozen functional‑connectivity predictor trained on 875 subjects, the authors find that split‑half reliability is near‑ceiling, but scan‑rescan reliability drops significantly. Even under a mismatched‑subject null, correlations remain substantial, indicating a strong population‑shared pattern, yet matched pairs show a significant person‑specific component. The authors recommend reporting scan‑rescan reliability alongside a permutation‑null control to avoid overstating individual specificity.