arXiv Machine Learning

Benchmarking External Generalization of SPD Matrix Learning for Resting-State fMRI Connectome Prediction

arXiv Machine Learning
Jul 30

An Attention-Based Framework for Alzheimers Disease Classification Using Resting-State fMRI

arXiv:2607. 26746v1 Announce Type: cross Abstract: Accurate identification of Alzheimers disease (AD) using resting-state functional magnetic resonance imaging (rs-fMRI) remains challenging due to the high dimensionality, noise, and complex inter-regional dependencies inherent in functional brain connectivity, which limit the effectiveness of traditional approaches based on handcrafted connectivity features or conventional machine learning models.

By Harshiddhi Pathak, Gowtham Reddy N, Mrinal Acharya, Manjunatha Mahadevappa
arXiv Computer Vision
Sep 11

Brain-PACE: A Deep Siamese MRI Framework for Modelling Longitudinal Brain Acceleration

Brain-PACE is a deep Siamese MRI framework that directly estimates the pace of structural brain ageing from paired T1‑weighted MRI scans, extending the LILAC model with spatial attention, soft label distribution learning, and a Cramér distance objective. In a study of participants with mild cognitive impairment, 42.6 % showed accelerated ageing, and faster Brain‑PACE scores correlated with greater functional and cognitive impairment as well as higher regional tau burden in key brain regions. The method improves probabilistic performance, reduces prediction bias, and provides predictive uncertainty, offering a complementary longitudinal imaging phenotype sensitive to early neurodegeneration.

By Samuel Maddox (School of Computing Sciences, University of East Anglia), Jacob Newman (School of Computing Sciences, University of East Anglia), Saber Sami (Norwich Medical School, University of East Anglia), Michal Mackiewicz (School of Computing Sciences, University of East Anglia), for the Alzheimer's Disease Neuroimaging Initiative, the Australian Imaging Biomarkers, Lifestyle flagship study of ageing
arXiv Machine Learning
Jul 9

STST-JEPA: Shallow-Target Spatio-Temporal Joint Embedding Prediction Architecture For EEG Self-Supervised Learning

arXiv:2607. 06629v1 Announce Type: new Abstract: Brain age -- the age inferred from a physiological recording -- is an emerging biomarker whose deviation from chronological age tracks neurological and psychiatric burden, and EEG is an attractive substrate for it because it is cheap, portable, and temporally rich.

By Roy Segal, Yoni Svechinsky, Tomer Fekete
arXiv Computer Vision
4d ago

A Multimodal Explainable Deep Learning Framework for Alzheimer's Disease Diagnosis using 3D Magnetic Resonance Imaging and Clinical Data

The study presents an explainable multimodal deep‑learning framework that combines a 3D CNN for T1‑weighted MRI with a feedforward network for harmonized clinical and demographic data to diagnose Alzheimer’s disease. Using 6,479 ADNI records and 1,703 OASIS‑3 records, the authors compare various model configurations on three‑way and pairwise diagnostic tasks, finding that performance and explanations vary by task, modality, fusion strategy, and cohort. SHAP and Integrated Gradients consistently highlight the MMSE score as the most influential tabular feature, while CAM‑based explanations differ across model setups and cohorts, indicating that explainability is not a stable property under cohort shift.

By Yusuf Brima, Marcellin Atemkeng, Lakshmana Rao Namamula, Antoine Vacavant
arXiv AI
Aug 24

SPD Matrix Learning for Neuroimaging Analysis: Perspectives, Methods, and Challenges

This review discusses how neuroimaging data can be represented as symmetric positive-definite (SPD) matrices and analyzed using the Riemannian geometry of the SPD manifold. It surveys the evolution from modality-specific SPD representations to geometric shallow and deep learning methods, emphasizing how these approaches maintain structural constraints while integrating modern AI techniques. The paper frames SPD matrix learning as a bridge between classical geometric statistics and contemporary machine learning in neuroimaging and brain‑computer interface research.

By Ce Ju, Reinmar Kobler, Antoine Collas, Motoaki Kawanabe, Cuntai Guan, Bertrand Thirion