The paper introduces HarmReduction, a benchmark for evaluating large language models (LLMs) on their ability to provide accurate and safe harm reduction information to people who use drugs (PWUD). The benchmark, HR-Basic, contains 2,160 question‑answer‑evidence pairs covering safety boundary checks, quantitative value provision, and polysubstance risk inference. Experiments show that even state‑of‑the‑art LLMs struggle with accuracy and can pose severe safety risks, underscoring the need for a dedicated evaluation framework.
arXiv:2602.06268v2 Announce Type: replace-cross Abstract: Large Language Models (LLMs) and Retrieval-Augmented Generation (RAG) systems are increasingly integrated into clinical workflows. However, p...
arXiv:2606. 28332v1 Announce Type: cross Abstract: Large language models (LLMs) are increasingly used for medical and health-related questions, yet their safety in high-risk medical scenarios remains poorly understood.
arXiv:2512. 01241v3 Announce Type: replace-cross Abstract: Large language models (LLMs) are routinely used by physicians and patients for medical advice, yet their clinical safety profiles remain poorly characterized.
arXiv:2607. 18665v1 Announce Type: new Abstract: Large language models (LLMs) increasingly support science, but they can also convert hazardous scientific knowledge into actionable misuse guidance.
DeepSafe‑SciHazard introduces a real‑world‑grounded benchmark for measuring scientific safety risks, comprising 2,400 hazardous and 600 oversafety questions across 12 disciplines. It defines a decomposed harm scoring system, DeHarm‑Score, that evaluates query severity, refusal behavior, and response‑level risk, further breaking down harm into executability and net‑new risk. An expert‑validation study shows DeHarm‑Score aligns 90.17% better with expert judgments than the best baseline, and the benchmark reveals that deep research agents score 32.3% higher on mean DeHarm‑Score than standard LLMs, highlighting a critical blind spot in current safety defenses.
Large language models (LLMs) increasingly support science, but they can also convert hazardous scientific knowledge into actionable misuse guidance. Existing benchmarks often rely on templated queries disconnected from real-world hazards, and employ LLM-as-a-Judge paradigms without domain grounding.
arXiv:2608. 03028v1 Announce Type: new Abstract: Applying a valid medication-safety rule when its patient-specific conditions are not met can produce an incorrect decision.
arXiv:2507. 02983v3 Announce Type: replace-cross Abstract: Large Language Models (LLMs) hold significant promise for transforming digital health by enabling automated medical question answering.
The paper introduces BAR, a Budget‑Aware LLM Reasoning framework that enhances post‑discharge risk prediction by integrating external medical knowledge graphs (KGs). BAR refines KGs into disease‑specific evidence graphs with support scores and provenance, then uses an LLM to plan, navigate, and verify evidence within a patient‑specific budget. Experiments on MIMIC‑III and MIMIC‑IV across eight diseases show BAR improves AUPRC by 3.4 points, raises citation precision from 59.8% to 77.9%, and uses only 62‑65% of the allotted budget.
arXiv:2601. 09853v3 Announce Type: replace-cross Abstract: Real-world health questions from patients often unintentionally embed false assumptions or premises.
arXiv:2508. 00923v3 Announce Type: replace Abstract: Large language models (LLMs) are increasingly used to answer health-related questions and support healthcare workflows, yet evidence for their safety still relies heavily on static benchmarks that can rapidly become obsolete or be optimized against.
The paper introduces DeToxR, a reinforcement‑learning‑enhanced large language model designed to support decision making in acute toxicology cases. It fuses unstructured narratives from paramedics and patients with structured vital‑sign data to predict co‑ingested substances across 14 classes. In preliminary validation, DeToxR outperforms baseline models, achieving higher micro‑F1 and recall scores for poison identification.