The paper introduces HarmReduction, a benchmark for evaluating large language models (LLMs) on their ability to provide accurate and safe harm reduction information to people who use drugs (PWUD). The benchmark, HR-Basic, contains 2,160 question‑answer‑evidence pairs covering safety boundary checks, quantitative value provision, and polysubstance risk inference. Experiments show that even state‑of‑the‑art LLMs struggle with accuracy and can pose severe safety risks, underscoring the need for a dedicated evaluation framework.
By Kaixuan Wang, Chenxin Diao, Jason T. Jacques, Zhongliang Guo, Shuai Zhao
arXiv:2606. 28332v1 Announce Type: cross Abstract: Large language models (LLMs) are increasingly used for medical and health-related questions, yet their safety in high-risk medical scenarios remains poorly understood.
By Yige Li, Jun Sun, Wei Zhao, Zhe Li, Yutao Wu, Hanxun Huang, Xiang Zheng, Xingjun Ma
arXiv:2508. 00923v3 Announce Type: replace Abstract: Large language models (LLMs) are increasingly used to answer health-related questions and support healthcare workflows, yet evidence for their safety still relies heavily on static benchmarks that can rapidly become obsolete or be optimized against.
By Jiazhen Pan (Cherise), Bailiang Jian (Cherise), Paul Hager (Cherise), Yundi Zhang (Cherise), Che Liu (Cherise), Friederike Jungmann (Cherise), Hongwei Bran Li (Cherise), Julian Canisius (Cherise), Chenyu You (Cherise), Junde Wu (Cherise), Jiayuan Zhu (Cherise), Fenglin Liu (Cherise), Yuyuan Liu (Cherise), Niklas Bubeck (Cherise), Moritz Knolle (Cherise), Chen (Cherise), Chen (Cherise), Christian Wachinger, Zhenyu Gong, Cheng Ouyang, Georgios Kaissis, Benedikt Wiestler, Daniel Rueckert
arXiv:2610.33592v1 Announce Type: new
Abstract: Augmented large language model (LLM) systems have reported high benchmark accuracies in rare disease diagnosis, yet their real-world clinical utility r...
By Jian Yang, Peilin Liu, Xiaohan Li, Songda Li, Yu Cao, Yuqing Feng, Haomin Li
arXiv:2606. 00027v1 Announce Type: cross Abstract: Large language models (LLMs) are increasingly deployed across healthcare, yet existing benchmarks fail to capture model behavior under adversarial or ethically complex conditions common in clinical practice.
By Andrei Marian Feier, Veysel Kocaman, Yigit Gul, Ahmet Korkmaz, Alexander Thomas, Aleksei Zakharov, Jay Gil, Mehmet Butgul, David Talby
arXiv:2601. 17642v2 Announce Type: replace Abstract: Safety alignment in Large Language Models is critical for healthcare; however, reliance on binary refusal boundaries often results in over-refusal of benign queries or unsafe compliance with harmful ones.
By Zhihao Zhang, Liting Huang, Guanghao Wu, Preslav Nakov, Heng Ji, Usman Naseem
arXiv:2512. 01241v3 Announce Type: replace-cross Abstract: Large language models (LLMs) are routinely used by physicians and patients for medical advice, yet their clinical safety profiles remain poorly characterized.
By David Wu, Fateme Nateghi Haredasht, Saloni Kumar Maharaj, Priyank Jain, Jessica Tran, Matthew Gwiazdon, Arjun Rustagi, Jenelle Jindal, Jacob M. Koshy, Vinay Kadiyala, Anup Agarwal, Bassman Tappuni, Brianna French, Sirus Jesudasen, Christopher V. Cosgriff, Rebanta Chakraborty, Jillian Caldwell, Susan Ziolkowski, David J. Iberri, Robert Diep, Rahul S. Dalal, Kira L. Newman, Kristin Galetta, J. Carl Pallais, Nancy Wei, Kathleen M. Buchheit, David I. Hong, Vartan Pahalyants, Ernest Y. Lee, Allen Shih, Tamara B. Kaplan, Vishnu Ravi, Sarita Khemani, Thomas A. Buckley, April S. Liang, Daniel Shirvani, Advait Patil, Nicholas Marshall, Kanav Chopra, Joel Koh, Adi Badhwar, Anastasia Perez, Austin J. Schoeffler, Mahbuba Tusty, Chase M. Walton, Liam G. McCoy, David J. H. Wu, Yingjie Weng, Sumant Ranji, Kevin Schulman, Nigam H. Shah, Jason Hom, Arnold Milstein, Arjun K. Manrai, Adam Rodman, Jonathan H. Chen, Ethan Goh
DeepSafe‑SciHazard introduces a real‑world‑grounded benchmark for measuring scientific safety risks, comprising 2,400 hazardous and 600 oversafety questions across 12 disciplines. It defines a decomposed harm scoring system, DeHarm‑Score, that evaluates query severity, refusal behavior, and response‑level risk, further breaking down harm into executability and net‑new risk. An expert‑validation study shows DeHarm‑Score aligns 90.17% better with expert judgments than the best baseline, and the benchmark reveals that deep research agents score 32.3% higher on mean DeHarm‑Score than standard LLMs, highlighting a critical blind spot in current safety defenses.
By Chunxiao Li, Yuan Xiong, Lijun Li, Tianyi Du, Wenlong Zhang, Lei Bai, Jing Shao
arXiv:2607. 18665v1 Announce Type: new Abstract: Large language models (LLMs) increasingly support science, but they can also convert hazardous scientific knowledge into actionable misuse guidance.
By Chunxiao Li, Yuan Xiong, Lijun Li, Tianyi Du, Wenlong Zhang, Lei Bai, Jing Shao
arXiv:2606. 07237v1 Announce Type: cross Abstract: Large Language Models (LLMs) are increasingly used in healthcare for tasks such as clinical question answering, diagnosis support, and report summarization.
By Mahdi Alkaeed
The paper introduces DiagSafe, a diagnostic evaluation framework that replaces binary safe/unsafe labels with prompt-level rubrics grounded in AI safety policies. DiagSafe uses a bilingual benchmark with an 84‑label safety taxonomy, comprising DiagBase and DiagAttack subsets, to assess safety and usefulness independently. Experiments show DiagSafe achieves high agreement with human annotations (95.34%) and strong inter‑judge consistency (Cohen’s κ = 0.864), revealing significant differences in unsafe rates and vulnerabilities across leading LLMs, especially in Chinese and multi‑turn contexts.
By Hongyu Li, Xinlong Huang, Zhan Yu, Jing Zhao, Zhe Zhao, Juntao Zhong, Xiong Kuang, Rui Yuan, ZhenXiang Yan, Huilin Xu, Haitao Yu, Lilin Wang, Rui Chen, Blaze Chen, Fengzong Lian, Renfen Hu
arXiv:2608.30703v1 Announce Type: cross
Abstract: Runtime guardrails are essential for reliable large language model (LLM) deployment, yet existing approaches typically rely on independent, external...
By Sing Team