arXiv AI

When do quantum views help? Complementary classical-quantum representations in multi-view fusion

The paper investigates when quantum machine learning can enhance predictive performance by fusing classical and quantum representations in multi‑view learning. It introduces a framework that preserves full classical inputs while adding simulated quantum features, and uses concatenation and attention to combine the views. Experiments on synthetic angular‑polynomial data and real datasets (Wine, Wisconsin Diagnostic Breast Cancer, Fashion‑MNIST, Steel Plates Faults) show that fusion improves predictions for targets that depend on complementary classical and quantum relationships, while classical‑only baselines perform best on other tasks.

arXiv Machine Learning
Jul 14

$\mathtt{Q^2SAR}$: overcoming classical bottlenecks in drug discovery via quantum multiple kernel learning

arXiv:2607. 11701v1 Announce Type: cross Abstract: Quantitative Structure-Activity Relationship ($\mathtt{QSAR}$) modeling is a foundational computational methodology in early-stage drug discovery, heavily relied upon for predicting compound toxicity, bioavailability, and therapeutic potential.

By Mariano Caruso, Daniel Ruiz, Alejandro Giraldo, Guido Bellomo
arXiv Machine Learning
Jun 30

Exploring the Effects of Entanglement on Quantum Machine Learning of Pathogen Epitope-Receptor Binding

arXiv:2606. 28655v1 Announce Type: cross Abstract: Parameterized quantum circuits (PQCs) provide a flexible substrate for hybrid quantum machine learning (QML), but their practical value on Noisy Intermediate-Scale Quantum (NISQ) devices remains an empirical question, especially because training depth and scale can introduce optimization challenges such as barren plateaus.

By Aspen Erlandsson Brisebois, Luis Pablo Gonzalez Dominguez, Shivansi Prajapati, Zahed Khatooni, Heather L. Wilson, Connor Burbridge, Brook Byrns, Sureesh Tikoo, Christophe Pere, Steven Rayan, Gordon Broderick
arXiv Statistics ML
Sep 18

Improving Sample Efficiency in Peptide-HLA Binding Prediction with Hybrid Quantum-Classical Neural Networks

The paper introduces a hybrid quantum-classical neural network (HQNN) for predicting peptide-HLA binding, a key step in personalized cancer immunotherapy. HQNN combines biological feature encoding, quantum feature extractors, and a quantum-enhanced classifier, outperforming a classical CNN baseline on two HLA alleles across all training sizes, especially when data are scarce. Ablation studies and noise-aware simulations confirm the benefits of the quantum components and the robustness of the approach under realistic hardware noise.

By Chenyan Jia, Cong Guo, Siyue Chen, Pengpeng Ye, Xiaochun Chen