arXiv Statistics ML

Improving Sample Efficiency in Peptide-HLA Binding Prediction with Hybrid Quantum-Classical Neural Networks

The paper introduces a hybrid quantum-classical neural network (HQNN) for predicting peptide-HLA binding, a key step in personalized cancer immunotherapy. HQNN combines biological feature encoding, quantum feature extractors, and a quantum-enhanced classifier, outperforming a classical CNN baseline on two HLA alleles across all training sizes, especially when data are scarce. Ablation studies and noise-aware simulations confirm the benefits of the quantum components and the robustness of the approach under realistic hardware noise.

arXiv Machine Learning
Jun 30

Exploring the Effects of Entanglement on Quantum Machine Learning of Pathogen Epitope-Receptor Binding

arXiv:2606. 28655v1 Announce Type: cross Abstract: Parameterized quantum circuits (PQCs) provide a flexible substrate for hybrid quantum machine learning (QML), but their practical value on Noisy Intermediate-Scale Quantum (NISQ) devices remains an empirical question, especially because training depth and scale can introduce optimization challenges such as barren plateaus.

By Aspen Erlandsson Brisebois, Luis Pablo Gonzalez Dominguez, Shivansi Prajapati, Zahed Khatooni, Heather L. Wilson, Connor Burbridge, Brook Byrns, Sureesh Tikoo, Christophe Pere, Steven Rayan, Gordon Broderick
arXiv AI
Sep 25

Hybrid Variational Quantum-Classical Framework with Adaptive Weighting and Efficiency Assessment

Hybrid Variational Quantum-Classical Framework with Adaptive Weighting and Efficiency Assessment introduces Sim‑HVQC, a hybrid deep quantum neural network that integrates an adaptive, parameter‑free SimAM weighting module with classical feature extraction to retain class‑discriminative information before encoding into a Variational Quantum Circuit. Unlike prior work limited to binary classification, this framework is trained and evaluated on multiple multi‑class datasets such as MNIST, KMNIST, Fashion‑MNIST, and EMNIST. The study highlights reproducibility, parameter efficiency, and interpretability through multi‑seed evaluation, parameter analysis, and latent/quantum feature inspection, with source code publicly available on GitHub.

By Dilli Hang Rai
arXiv AI
Jun 3

Scalable On-Hardware Training of Quantum Neural Networks and Application to Clinical Data Imputation

arXiv:2606. 03517v1 Announce Type: cross Abstract: Training quantum neural networks (QNNs) on quantum hardware is currently bottlenecked by the cost of gradient estimation: standard parameter-shift methods require a number of circuit evaluations that grows quadratically with the number of trainable parameters, making hardware-based optimisation impractical beyond small system sizes.

By Natansh Mathur, Panagiotis Kl. Barkoutsos, Masako Yamada, Martin Roetteler, Iordanis Kerenidis
arXiv Machine Learning
Jul 27

Do emulated quantum circuits change what CNNs look at? Performance and explainability comparison in medical image classification

arXiv:2607. 21186v1 Announce Type: cross Abstract: Numerous studies have analyzed the use of hybrid quantum-classical convolutional neural networks as a promising alternative to classical deep learning.

By Guillermo Rubi\~nos Rodr\'iguez, Mart\'in Ottavianelli, Mateo Alonso, Gonzalo Bl\'azquez Gil, Boris-Stephan Rauchmann, Pablo D\'iez-Valle, Sergio Altares-L\'opez
arXiv Machine Learning
Aug 28

Classical and Hybrid Quantum Machine Learning for Trigger-Like Event Selection on CMS Open Data: An Eight-Qubit, PCA-Constrained Benchmark

The paper compares classical and hybrid quantum machine learning models for a trigger-like binary classification task using CMS open data. Eight classical models (SVM, ANN, CNN, LSTM) and eight quantum counterparts are evaluated under identical preprocessing, data splits, and decision thresholds, with performance measured by accuracy, ROC‑AUC, F1‑score, precision, and recall. The best classical model is an artificial neural network (93.53 % accuracy, 0.9819 ROC‑AUC), while the best quantum model is a quantum convolutional network (90.89 % accuracy, 0.9731 ROC‑AUC), indicating that within an eight‑qubit budget the quantum models do not surpass the classical ones.

By Tariq Mahmood, Muhammad Awais Rafique, Talab Hussain, Juan Pablo Perez Aguilar, Alfredo Raya, Muhammad Ahsan