The paper introduces a hybrid quantum-classical neural network (HQNN) for predicting peptide-HLA binding, a key step in personalized cancer immunotherapy. HQNN combines biological feature encoding, quantum feature extractors, and a quantum-enhanced classifier, outperforming a classical CNN baseline on two HLA alleles across all training sizes, especially when data are scarce. Ablation studies and noise-aware simulations confirm the benefits of the quantum components and the robustness of the approach under realistic hardware noise.
By Chenyan Jia, Cong Guo, Siyue Chen, Pengpeng Ye, Xiaochun Chen
arXiv:2608. 04379v1 Announce Type: cross Abstract: We propose a method to optimize the correlation among convolutional neural network (CNN) features that are used as inputs to quantum neural network (QNN) to enhance image classification accuracy.
By Minseo Seong, Youngwook Kim
arXiv:2607. 21186v1 Announce Type: cross Abstract: Numerous studies have analyzed the use of hybrid quantum-classical convolutional neural networks as a promising alternative to classical deep learning.
By Guillermo Rubi\~nos Rodr\'iguez, Mart\'in Ottavianelli, Mateo Alonso, Gonzalo Bl\'azquez Gil, Boris-Stephan Rauchmann, Pablo D\'iez-Valle, Sergio Altares-L\'opez
arXiv:2510. 03389v2 Announce Type: replace-cross Abstract: Current quantum computers require algorithms that use limited resources economically.
By Jonas J\"ager, Philipp Els\"asser, Elham Torabian
arXiv:2606. 28252v1 Announce Type: cross Abstract: Early detection of oral cancer markedly improves clinical outcomes, yet specialized diagnostic tools remain scarce in low-resource settings.
By Akshay Bhagwan Sonawane, Sophie Choe, Lakshman Tamil
We propose a method to optimize the correlation among convolutional neural network (CNN) features that are used as inputs to quantum neural network (QNN) to enhance image classification accuracy. Unlike prior approaches that employ orthogonal decomposition as preprocessing, we intentionally introduce correlated features that are more physically compatible with QNN.
arXiv:2604. 10933v2 Announce Type: replace-cross Abstract: Deep neural networks remain highly vulnerable to adversarial perturbations, limiting their reliability in security- and safety-critical applications.
By Navid Azimi, Aditya Prakash, Yao Wang, Li Xiong
arXiv:2608. 06846v1 Announce Type: cross Abstract: We test whether a parameterized quantum circuit (PQC) improves a hybrid quantum-classical model's performance on classical datasets, using an interface-matched classical map as the control while holding all other components fixed.
By Hao-Yuan Chen
The paper proposes Entanglement-Weighted Pruning (EWP), a method for unlearning a client’s contribution from a federated quantum classifier without retraining from scratch. EWP scores each trainable circuit parameter by combining a Fisher‑information estimate on the target client’s data with a structural entanglement weight, pruning the lowest‑scoring parameters and optionally fine‑tuning the remaining ones. Experiments on a four‑qubit data‑re‑uploading ansatz trained with FedAvg across five simulated supply‑chain‑risk clients show that EWP achieves accuracy comparable to full retraining while reducing forgetting and wall‑clock time by about sixteenfold, outperforming random, Fisher‑only, or entanglement‑only pruning.
By Aditya Kumar, Sumit Chongder
arXiv:2606. 03517v1 Announce Type: cross Abstract: Training quantum neural networks (QNNs) on quantum hardware is currently bottlenecked by the cost of gradient estimation: standard parameter-shift methods require a number of circuit evaluations that grows quadratically with the number of trainable parameters, making hardware-based optimisation impractical beyond small system sizes.
By Natansh Mathur, Panagiotis Kl. Barkoutsos, Masako Yamada, Martin Roetteler, Iordanis Kerenidis
arXiv:2412. 09486v2 Announce Type: replace-cross Abstract: The literature reflects a mutually beneficial relationship between machine learning and quantum computing, where progress in one field frequently drives improvements in the other.
By Leandro C. Souza, Bruno C. Guingo, Gilson Giraldi, Renato Portugal
arXiv:2607. 09113v1 Announce Type: cross Abstract: Data scarcity and class imbalance are persistent challenges in machine learning that degrade model generalization and introduce predictive bias.
By Tanapol Nuatho, Narisorn Sangnakara, Prapong Prechaprapranwong, Rajchawit Sarochawikasit