arXiv Machine Learning
Jun 10
Pre-AF 13: An Interpretable Atrial Fibrillation Risk Score Mined from Discharge Reports
arXiv:2606. 10725v1 Announce Type: new Abstract: Background.
Trajectory-guided discharge stratification for heart failure using short-context electronic health record sequence modeling
arXiv:2511. 16839v4 Announce Type: replace-cross Abstract: Purpose: Heart failure (HF) discharge planning depends on identifying patients at risk of deterioration or death, yet accurate prediction from routinely collected electronic health records (EHRs) remains challenging.
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arXiv Machine Learning
Jun 24
PORTER: Language-Grounded Event Representations for Portable Structured EHR Foundation Models
arXiv:2606. 24102v1 Announce Type: cross Abstract: Most electronic health record (EHR) foundation models encode clinical events as discrete event tokens from a fixed vocabulary and therefore cannot directly represent events containing unseen concepts or new combinations of concepts and attributes such as numeric values.
arXiv AI
Sep 15
Rolling Day-Wise Mortality Prediction in Critically Ill Patients With AKI on CRRT Utilizing Machine Pressure Waveforms
This study develops a rolling day‑wise mortality prediction model for critically ill patients with acute kidney injury on continuous renal replacement therapy (CRRT) by incorporating minute‑level machine pressure waveforms alongside electronic health record (EHR) data. After cleaning the raw machine data—aligning it with therapy intervals, removing priming and downtime minutes, and denoising artifacts—the authors trained a transformer‑based stacked ensemble that fuses a sequence transformer with classical models using circuit‑instability features and clinical variables. In a multi‑center benchmark of 976 patients, the combined model achieved a one‑day mortality AUROC of 0.766, outperforming machine‑only (0.625) and EHR‑only (0.717) models, and SHAP analysis highlighted key pressure‑related features such as filter pressure, transmembrane pressure, and access‑to‑return difference. whyItMatters":"By integrating previously discarded CRRT machine data, the study provides a continuous, real‑time risk signal that could enable earlier detection of patient deterioration and improve mortality prediction in a high‑risk population."
arXiv Machine Learning
Aug 4
EHR2Path: Comprehensive Pathway-Level Modeling of Longitudinal Patient Trajectories from Multimodal Electronic Health Records
arXiv:2506. 04831v3 Announce Type: replace Abstract: Forecasting how a patient's condition is likely to evolve, including possible deterioration, recovery, treatment needs, and care transitions, could support more proactive and personalized care, but requires modeling heterogeneous and longitudinal electronic health record (EHR) data.
arXiv AI
Jun 29
Chronic Kidney Disease Prognosis Prediction Using Transformer
arXiv:2511. 02340v3 Announce Type: replace Abstract: Chronic Kidney Disease (CKD) affects nearly 10\% of the global population and often progresses to end-stage renal failure.
arXiv Machine Learning
Sep 14
Representation Before Training: A Practical Benchmark for Generative Medical Event Model Tokenization
The study benchmarks tokenization choices for generative medical event models, evaluating quantization granularity, reference-range anchoring, code–value fusion, numeric and temporal encodings, and native versus harmonized event representations. Using Llama and Qwen architectures, 156 models were trained and assessed on early hospitalization data, showing that fusing codes with value deciles and using event-order or admission-relative RoPE embeddings improved predictive performance. The Common Longitudinal Intensive Care Unit Data Format (CLIF) reduced token count by 30.8% while enhancing outcomes in most families.
arXiv Machine Learning
Aug 19
Mr.Dec: Daily-Scale Longitudinal Multimodal Modeling for 30-Day Readmission Prediction
Mr.Dec is a new Transformer‑decoder model that predicts 30‑day hospital readmission by treating each admission as a chronological sequence of daily multimodal events, integrating Electronic Health Record updates and Chest X‑ray findings. It uses disease‑specific supervised contrastive learning to shape a diagnosis‑aware latent space and preserves day‑level clinical signals that other methods often compress. Experiments on MIMIC‑IV and MIMIC‑CXR datasets show state‑of‑the‑art performance and the model can highlight "Critical Days" for actionable real‑time risk stratification.
arXiv AI
Sep 1
Predicting Future Organ Dysfunction in ICU Patients Using Temporal Convolutional Networks on MIMIC-IV Data
arXiv:2608.29301v1 Announce Type: new Abstract: Predicting future organ dysfunction in Intensive Care Unit (ICU) patients is critical for early clinical intervention, yet existing machine learning ap...
arXiv Machine Learning
Jul 20
LLM4EHR: Aligning Clinical Time Series with Medical Event Sequences via Large Language Models
arXiv:2607. 15447v1 Announce Type: new Abstract: Recent research in clinical machine learning, focusing on outcome predictions in intensive care unit (ICU), has shifted from bespoke supervised models to foundation models, utilising modern representation learning methods.
arXiv AI
Sep 1
INTERVenE: Temporal-Abstraction-Interval Based Transformers for Short-Horizon Medical Event Prediction
INTERVenE introduces Transformer models that use a knowledge‑based temporal abstraction (KBTA) token stream of named clinical concepts instead of raw measurements, enabling per‑token attributions to resolve directly to clinical concepts. Two variants are offered: an auto‑regressive decoder that generates future abstraction trajectories with step‑wise risk readouts, and a bidirectional encoder that jointly predicts risk and time‑to‑event in a single pass. On 57,078 MIMIC‑IV admissions, the encoder variant outperforms neural baselines with a support‑weighted AUPRC of 0.672 and AUROC of 0.901, while the decoder provides complementary token‑level risk trajectories.
arXiv Machine Learning
Jun 8
One Loss to Rule Them All: Marked Time-to-Event for Structured EHR Foundation Models
arXiv:2602. 00541v2 Announce Type: replace Abstract: Clinical events captured in Electronic Health Records (EHR) are irregularly sampled and may consist of a mixture of discrete events and numerical measurements, such as laboratory values or treatment dosages.
arXiv AI
Sep 10
PGP-Clinical-TimeKAN: Prior-Guided Joint Probabilistic Forecasting of Clinical Trajectories
PGP-Clinical-TimeKAN is a trajectory-first framework for joint probabilistic forecasting of multivariate physiological data, combining missingness-aware temporal encoders, a soft organ-system prior, patient-specific relations, nonlinear Kolmogorov‑Arnold messages, and a low‑rank multivariate Student‑t head. Evaluated on a MIMIC‑IV cohort of 6,882 patients, it achieves the second‑lowest normalized MAE and the lowest RMSE among 13 models, while providing calibrated probabilistic forecasts with empirical coverage at 50%, 80%, and 95% intervals. Ablation studies show that relational structure is critical for performance, and increasing covariance rank improves likelihood but not point accuracy. whyItMatters":"The model demonstrates that joint trajectory forecasting can yield highly accurate, calibrated predictions of physiological trajectories, offering a potentially inspectable intermediate task for clinical deterioration prediction."