Whole slide images (WSIs) provide rich diagnostic information for computational pathology, but their gigapixel scale, stain variation, scanner differences, tissue artifacts, and limited expert annotation make robust model training challenging. This paper presents a multi-source Masked Autoencoder (MAE) framework, named ProsMAE, for histopathology representation learning.
arXiv:2607. 18218v1 Announce Type: cross Abstract: Foundation models have emerged as a driving force in computational pathology, with the potential to transform cancer diagnosis, prognosis, and treatment selection by learning transferable representations from large-scale histopathology data.
By Naoto Usuyama, Jeya Maria Jose Valanarasu, Sicong Yao, Hanwen Xu, Jaspreet Bagga, Guanghui Qin, Robert E. Kramer, Cliff Wong, Soohee Lee, Hao Qiu, Theodore Zhengde Zhao, Racheli Ben Shimol, Angela Crabtree, Kevin Matlock, Eduardo Alejandro Lozano Garcia, Naiteek Sangani, Alberto Santamaria-Pang, Jason Entenmann, Alexandra Q. Bartlett, Bill J. Wright, Bernard A. Fox, Brian Piening, Sheng Zhang, Sheng Wang, Tristan Naumann, Carlo Bifulco, Hoifung Poon
arXiv:2608. 03990v1 Announce Type: new Abstract: Synthetic histopathology image generation has emerged as an approach that may address data scarcity in computational pathology, yet current evaluation methodologies may not fully assess synthetic data quality for medical applications.
By Seyed Kahaki, Shijie Li, Weijie Chen, Nicholas Petrick
Deep learning-based computer-aided diagnosis (CAD) systems have shown strong performance in breast cancer diagnosis, particularly for classification tasks in mammography. However, domain shifts across multi-site datasets remain a challenge, especially when models are applied to unseen domains.
arXiv:2606. 30951v1 Announce Type: cross Abstract: Micro-ultrasound ($\mu$US) is a new, emerging, and promising imaging modality for prostate cancer (PCa) detection, but accurate identification of suspicious tissue remains highly dependent on clinical experience, leading to substantial inter-observer variability.
By Mohammad Mahdi Abootorabi, Sina Namazi, Armin Saadat, Lyuyang Wang, Obed Dzikunu, Paul F. R. Wilson, Zhuoxin Guo, Brian Wodlinger, Parvin Mousavi, Purang Abolmaesumi
arXiv:2606. 12346v1 Announce Type: cross Abstract: Hematoxylin and eosin (H&E) staining is the cornerstone of histopathology, yet scalable, quantitative analysis of H&E whole-slide images (WSIs) remains a central challenge in computational pathology.
By Kai Standvoss, Miriam H\"agele, Rosemarie Krupar, Julika Ribbat-Idel, Jennifer Altsch\"uler, Gerrit Erdmann, Hans Pinckaers, Evelyn Ramberger, Madleen Drinkwitz, \'Ad\'am N\'arai, Alexander M\"ollers, Katja Lingelbach, Sebastian Kons, Lukas H\"onig, Recepcan Adig\"uzel, Joana Bai\~ao, Alberto Megina Gonzalo, Marius Teodorescu, Marie-Lisa Eich, Paolo Chetta, Shakil Merchant, Verena Aumiller, Simon Schallenberg, Andrew Norgan, Klaus-Robert M\"uller, Lukas Ruff, Maximilian Alber, Frederick Klauschen
arXiv:2608. 16959v1 Announce Type: cross Abstract: Breast cancer is one of the most common types of cancer among women around the world.
By Nabil Ashab, Soumit Kumar Kundu, Saif Mahmud Parvez, Shahadat Hossain Sohag, Bidhan Biswas, Nazmus Subha
arXiv:2606. 06983v1 Announce Type: cross Abstract: Computational pathology requires visual representations that transfer across diverse clinical endpoints and remain robust to variation in magnification, staining, scanner type, slide preparation, and input resolution.
By Bokai Zhao, Yiyang Zhang, Long Bai, Tai Ma, Hanqing Chao, Minfeng Xu
arXiv:2601. 08127v2 Announce Type: replace-cross Abstract: Expert-annotated training data remains the critical bottleneck for AI in histopathology, particularly for rare pathologies where even dozens of cases may be unavailable.
By Mohamad Koohi-Moghadam, Mohammad-Ali Nikouei Mahani, Rex K. H. Au-Yeung, Raymond Yu O, Monalyn Marabi, Piyapharom Intarawichian, Fabian Z. X. Lean, Andrew Ferguson, Kyongtae Tyler Bae
arXiv:2608. 10271v1 Announce Type: cross Abstract: Breast density classification is a critical component of breast cancer risk assessment, yet AI models often struggle to generalize across clinical sites due to vendor-specific acquisition styles.
By Hongyi Pan, Gorkem Durak, Halil Ertugrul Aktas, Andrea Mia Bejar, Mustafa Ege Seker, Nebile Alibeyoglu, Rumeysa Guclu, Rana Gunoz Comert Bozkurt, Sibel Ozkan Gurdal, Neslihan Cabioglu, Beyza Ozcinar, Ravza Yilmaz, Vahit Ozmen, Erkin Aribal, Sukru Mehmet Erturk, Yalda Zafari, Mohamed Mabrok, Kayhan Batmanghelich, Mohammad Yaqub, Ziyue Xu, Ulas Bagci
arXiv:2608. 10657v1 Announce Type: cross Abstract: Leukemia cell image classification is challenged by real-world domain shifts from acquisition, staining, illumination, and site protocols, causing single-dataset models to generalize poorly in real clinical scenarios.
By Carlos Zamora, Hiram Zuniga, Ulises Orozco-Rosas, Kenia Picos
arXiv:2606. 07590v1 Announce Type: cross Abstract: Pathology foundation models are pretrained on large streams of WSI-derived patches, while supervision during data construction is often slide-level, sparse, or heterogeneous.
By Mingyi He, Xinyi Guo, Xitong Ling, Weiming Chen, Jiawen Li, Lianghui Zhu, Minxi Ouyang, Mingxi Fu, Yizhi Wang, Tian Guan