Frontier large language models (LLMs) are increasingly integrated into scientific workflows, yet their growing biological capabilities may outpace current safeguards. To assess the biological risks of frontier models, we develop Intern-BioBreaker, a specialized bio-red-teaming model, together with an integrated computational-to-physical framework that couples model-level stress testing with wet-lab validation.
arXiv:2608. 02684v1 Announce Type: cross Abstract: Large Language Models (LLMs) are accelerating biological research, yet this same capability poses a critical biosecurity threat: models that assist in protein engineering can equally be prompted to generate predicted toxin-like sequences, potentially lowering the barrier to biological misuse.
By Shu Quan, Tianfang Hao, Sitong Fang, He Geng, Jiayi Zhou, Boyuan Chen, Kaile Wang, Donghai Hong, Juntao Dai, Yaodong Yang, Jiaming Ji
arXiv:2504. 17247v3 Announce Type: replace Abstract: Deep learning-based antimicrobial peptide (AMP) discovery faces critical challenges such as limited controllability, lack of representations that efficiently model antimicrobial properties, and low experimental hit rates.
By Diogo Soares, Leon Hetzel, Paulina Szymczak, Marcelo Der Torossian Torres, Johanna Sommer, Cesar de la Fuente-Nunez, Fabian Theis, Stephan G\"unnemann, Ewa Szczurek
arXiv:2606.27824v3 Announce Type: replace-cross
Abstract: Therapeutic peptides are a promising drug modality, but their generation must satisfy multiple therapeutic constraints. We introduce BindSafe...
By Takashi Fujiwara, Hikaru Shindo, Kaushalya Madhawa, Jun Jin Choong, Shuan Chen, Yuna Oikawa, Yiming Zhang, Gyubok Lee, Keisuke Ozawa
The paper introduces T-MAP, a trajectory‑aware evolutionary search technique designed to red‑team large language model agents by exploiting vulnerabilities that arise during multi‑step tool execution. Unlike traditional methods that focus on harmful text, T‑MAP uses execution trajectories to generate adversarial prompts that bypass safety guardrails and achieve harmful objectives through actual tool interactions. Experiments across various Model Context Protocol environments show that T‑MAP outperforms baseline methods in attack realization rate and remains effective against advanced models such as GPT‑5.2, Gemini‑3‑Pro, Qwen3.5, and GLM‑5.
By Hyomin Lee, Sangwoo Park, Yumin Choi, Sohyun An, Seanie Lee, Sung Ju Hwang
Antimicrobial peptides (AMPs) often act against multiple pathogen classes, making multi-label activity prediction a more realistic screening target than binary antimicrobial classification. The ESCAPE...