arXiv Computer Vision

Comprehensive Evaluation and Fine-Tuning of Foundational Cell Nuclei Segmentation Models in Renal Pathology

arXiv AI
Jun 9

Robust Renal Mass Segmentation on CT: A Validation Study of an AI-Based Framework

arXiv:2505. 07573v2 Announce Type: replace-cross Abstract: Renal mass segmentation has important potential to enhance the clinical workflow, especially in settings requiring quantitative assessments.

By Sarah de Boer, Hartmut H\"antze, Kiran Vaidhya Venkadesh, Myrthe A. D. Buser, Gabriel E. Humpire Mamani, Lina Xu, Lisa C. Adams, Jawed Nawabi, Keno K. Bressem, Bram van Ginneken, Mathias Prokop, Alessa Hering
arXiv AI
Sep 2

Semantic-Guided Multimodal Preprocessing for Vision Transformer-Based Clear Cell Renal Cell Carcinoma Grading

The paper introduces a semantic‑guided multimodal preprocessing technique that fuses nuclei classification maps with RGB histopathology images for Vision Transformer‑based grading of clear cell renal cell carcinoma. By concatenating classification map channels and applying multiplicative modulation, the method achieves a balanced accuracy of 0.916, markedly surpassing an RGB‑only baseline (0.707) and prior max‑voting approaches (0.427). Sensitivity analysis shows the 21‑percentage‑point improvement remains robust under simulated perturbations matching current nuclei classifier error rates, indicating effective use of imperfect nuclear‑level information.

By Fatemeh Javadian, Zhu Chen, Zahra Aminparast, Johannes Stegmaier
arXiv AI
Jun 17

SegTME-UNI2: A Foundation Model-Based Framework for Generalisable Multiclass Cell Segmentation and LLM-Driven Tumour Microenvironment Characterisation in Histopathology

arXiv:2606. 17702v1 Announce Type: cross Abstract: Characterising the tumour microenvironment (TME) from routine H&E-stained histology images requires simultaneous cell segmentation, feature extraction, and interpretable clinical reporting.

By Wan Siti Halimatul Munirah Wan Ahmad, Faris Syahmi Samidi, Mohammad Badal Ahmmed, Vimal Angela Thiviyanathan, Selvam James Thavaraj, Anwar P. P. Abdul Majeed
arXiv AI
Jun 11

Atlas H&E-TME: Scalable AI-Based Tissue Profiling at Expert Pathologist-Level Accuracy

arXiv:2606. 12346v1 Announce Type: cross Abstract: Hematoxylin and eosin (H&E) staining is the cornerstone of histopathology, yet scalable, quantitative analysis of H&E whole-slide images (WSIs) remains a central challenge in computational pathology.

By Kai Standvoss, Miriam H\"agele, Rosemarie Krupar, Julika Ribbat-Idel, Jennifer Altsch\"uler, Gerrit Erdmann, Hans Pinckaers, Evelyn Ramberger, Madleen Drinkwitz, \'Ad\'am N\'arai, Alexander M\"ollers, Katja Lingelbach, Sebastian Kons, Lukas H\"onig, Recepcan Adig\"uzel, Joana Bai\~ao, Alberto Megina Gonzalo, Marius Teodorescu, Marie-Lisa Eich, Paolo Chetta, Shakil Merchant, Verena Aumiller, Simon Schallenberg, Andrew Norgan, Klaus-Robert M\"uller, Lukas Ruff, Maximilian Alber, Frederick Klauschen
arXiv AI
Aug 24

CellPath-Bench: A Multidimensional Benchmark for Whole-Slide Cellular Representations in Pathology Foundation Models

CellPath-Bench is a new benchmark that evaluates whole-slide cellular representations in pathology foundation models (PFMs) by using 25 spatially aligned H&E–Xenium tissue sections from 11 organs and over 7 million cells. It introduces metrics such as Cell Representation Advantage (CRA) and Cell Representation Transferability (CRT) to assess how well frozen PFMs encode cell-type information and generalize across tissue sections, datasets, and organs. The benchmark was applied to 30 PFMs, revealing significant model-dependent differences in cell-type decodability and cross-domain generalization, and offers a standardized framework for auditing cellular information in frozen PFM representations.

By Bokai Zhao, Yiyang Zhang, Hanqing Chao, Yawei Ma, Long Bai, Tai Ma, Minfeng Xu, Ming Song, Tianzi Jiang
arXiv Computer Vision
Sep 18

Seeing Abnormal from Normal: Glomerular Abnormality in Representations of Normal Renal Morphology

The paper introduces NoRDeC, a one‑class anomaly detection framework that uses a frozen residual U‑Net backbone pretrained on normal renal morphology to identify and characterize glomerular abnormalities. By combining Mahalanobis normal‑reference scoring with layer‑wise representation analysis and centered kernel alignment, NoRDeC achieves high AUROC scores across multiple abnormality categories, outperforming existing methods such as PaDiM and PatchCore. The study demonstrates that a model trained solely on normal glomeruli can detect unseen pathological subtypes and reveal subtype‑dependent changes in inter‑layer relationships without requiring abnormal training examples.

By Greta Hasko, Rachit Saluja, Tianyu Shi, Leiyue Zhao, Yuechen Yang, Daniel Reisenbuechler, Tianyuan Yao, Zhenhao Guo, John Cannon, Haichun Yang, Yuankai Huo, Yuling Chi, Lorraine Gudas, Mert R. Sabuncu, Yihe Yang, Ruining Deng