arXiv Machine Learning

Cross-Modal Fusion of OCT and OCT angiography enface for Improved Diagnostics of Diabetic Retinopathy

arXiv:2607. 03959v1 Announce Type: cross Abstract: Diabetic retinopathy (DR) is a leading cause of vision impairment worldwide, highlighting the need for accurate and accessible screening tools.

arXiv Machine Learning
Aug 31

Explainable Diabetic Retinopathy Classification Using Vision Foundation Models

The paper presents an explainable diabetic retinopathy classification framework that leverages vision foundation models—DINOv2, CLIP, and Vision Transformer—combined with various transfer learning techniques such as full fine‑tuning, linear probing, and Low‑Rank Adaptation (LoRA). Using the ODIR dataset for internal validation and the APTOS dataset for external testing, DINOv2‑LoRA achieved the best internal AUROC (0.758) while DINOv2 and ViT full fine‑tuning reached the highest external AUROC (0.920). Explainability was assessed with Grad‑CAM and HiResCAM against expert‑annotated lesion masks from IDRiD, using Dice, IoU, and Pointing Game metrics, confirming that model attention aligns with clinically relevant retinal lesions.

By Abhishek Verma, Anila Krishna, Abhishek Gajanan Bankar, Juan Miguel Lopez Alcaraz
arXiv AI
Jun 16

EyeMVP: OCT-Informed Fundus Representation Learning via Paired CFP--OCT Pretraining

arXiv:2606. 15129v1 Announce Type: cross Abstract: Color fundus photography (CFP) is the mainstay for large-scale retinal screening, yet its diagnostic capacity is constrained by the lack of depth-resolved structural information.

By Zhuo Deng, Ruiheng Zhang, Ziheng Zhang, Weihao Gao, Yitong Li, Qian Wang, Lei Shao, Jiaoyue Dong, Zhixi Zeng, Lijian Fang, Haibo Wang, Xiaobin Lin, Tao Liu, Zhicheng Du, Zhengwei Zhang, Lin Yang, Zheng Gong, Xinyu Zhao, Zhenquan Wu, Fang Li, Zhiguang Zhou, Guoming Zhang, Sun Jing, Han Lv, Wenbin We, Lan Ma
arXiv Machine Learning
Jul 24

Counterfactual Explainability Framework With CycleGAN And Counterfactual-Classifier Alignnment Score for Retinal Disease Classification

arXiv:2607. 21068v1 Announce Type: new Abstract: Automated detection of vision impairing retina-based ocular conditions from fundus images is important for early screening, timely referral and reducing dependency on specialist-only assessment, for which neural network-based deep learning (DL) models have been widely utilized.

By Kritanu Chattopadhyay, Sayanjit Singha Roy, Soumya Chatterjee
arXiv Computer Vision
Aug 28

Automated 2D and 3D Segmentation of AMD and DME Lesions in OCT

This study presents four deep‑learning pipelines—two‑dimensional and three‑dimensional—for segmenting age‑related macular degeneration (AMD) and diabetic macular edema (DME) lesions in optical coherence tomography (OCT) images. The models achieve Dice scores between 0.76 and 0.82 and demonstrate strong volumetric and surface calibration (r_vol, r_surf ≥ 0.97) on an in‑domain validation set. Generalization was assessed on the OLIVES clinical cohort using proxy metrics such as biomarker AUROC, central subfield thickness correlation, and longitudinal concordance, showing that the predictions still track clinical biomarkers outside the training distribution, albeit with reduced strength.

By Lucia Sundberg, Zhihao Zhao, M. Ali Nasseri
arXiv Computer Vision
Sep 3

Evaluating Fundus-Specific Foundation Models for Diabetic Macular Edema Detection

The study evaluates fundus-specific foundation models (FM) for detecting diabetic macular edema (DME) in retinal images. It compares two popular FM—RETFound and FLAIR—against a lightweight EfficientNet-B0 backbone across multiple datasets (IDRiD, MESSIDOR-2, and OCT-and-Eye-FundusImages). Results indicate that FM do not consistently outperform fine‑tuned CNNs; EfficientNet-B0 often matches or exceeds FM performance, with FLAIR being the most competitive FM.

By Franco Javier Arellano, Jos\'e Ignacio Orlando
arXiv Machine Learning
Aug 18

In Defense of OCTA: The Reconstruction-Utility Gap in OCT-to-OCTA Synthesis

arXiv:2608. 15626v1 Announce Type: new Abstract: Optical coherence tomography angiography (OCTA) images retinal blood flow, giving capillary-perfusion and foveal-avascular-zone biomarkers that grade diabetic-retinopathy ischemia.

By Michael Chertok, Alon Tiosano, Orly Gal-Or, Lior Kramarski, Einav Baharav Shlezinger, Irit Bahar, Lior Wolf