arXiv AI By Mustafa Kadhim, Viktor Rogowski, Emilia Persson, Camila Gonzalez, Andr\'e Haraldsson, Sofie Ceberg, Mikael Nilsson, Malin K\"ugele, Sven B\"ack, Christian Jamtheim Gustafsson

Catching magnetic resonance imaging outliers in artificial intelligence-supported radiotherapy workflows: unsupervised detection and localization of image anomalies using deep learning

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arXiv:2605. 24609v2 Announce Type: replace-cross Abstract: Artificial intelligence is increasingly integrated into radiotherapy workflows, yet such pipelines remain vulnerable to out-of-distribution image data that may introduce unexpected behavior in clinical tasks.

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arXiv AI
Jun 30

Towards Modality-Agnostic Medical Image Anomaly Detection: A Training-Free Manifold Refinement Approach

arXiv:2604. 19191v2 Announce Type: replace-cross Abstract: Deploying AI-based anomaly detection across diverse clinical imaging settings remains challenging because most existing methods rely on modality-specific architectures, anatomical priors, or extensive retraining, limiting their use as general-purpose screening tools.

By Pritam Kar, Gouri Lakshmi S, Saptarshi Bej
arXiv AI
2d ago

MIRTO: a registration-gated, multiverse-tested evaluation protocol for unsupervised anomaly segmentation in brain MRI

MIRTO is an evaluation protocol for unsupervised anomaly segmentation in brain MRI that explicitly documents key methodological choices—such as registration alignment, threshold setting, and false‑positive budgeting—and measures their impact. It applies a registration check, uses validation data for thresholding, reports realized false‑positive volumes, and repeats each comparison across 15,552 evaluation pipelines with bootstrap intervals. In a study on four UAD methods and 312 BraTS 2020 subjects, MIRTO revealed that an axis‑order mismatch dramatically lowered a diffusion model’s voxel AUROC, and that many performance differences were driven by lesion definition and threshold transfer rather than model quality.

By Negin Kafee Hernashki, Soumick Chatterjee