arXiv Computer Vision
Sep 11

Brain-PACE: A Deep Siamese MRI Framework for Modelling Longitudinal Brain Acceleration

Brain-PACE is a deep Siamese MRI framework that directly estimates the pace of structural brain ageing from paired T1‑weighted MRI scans, extending the LILAC model with spatial attention, soft label distribution learning, and a Cramér distance objective. In a study of participants with mild cognitive impairment, 42.6 % showed accelerated ageing, and faster Brain‑PACE scores correlated with greater functional and cognitive impairment as well as higher regional tau burden in key brain regions. The method improves probabilistic performance, reduces prediction bias, and provides predictive uncertainty, offering a complementary longitudinal imaging phenotype sensitive to early neurodegeneration.

By Samuel Maddox (School of Computing Sciences, University of East Anglia), Jacob Newman (School of Computing Sciences, University of East Anglia), Saber Sami (Norwich Medical School, University of East Anglia), Michal Mackiewicz (School of Computing Sciences, University of East Anglia), for the Alzheimer's Disease Neuroimaging Initiative, the Australian Imaging Biomarkers, Lifestyle flagship study of ageing
arXiv AI
Oct 1

GateSPINE: Gated Cross-View Fusion for Lumbar Spine MRI Report Generation

GateSPINE is a vision‑language framework designed for automated lumbar spine MRI report generation. It fuses sagittal T1 and T2 volumes using a training‑free gated cross‑view fusion module, then encodes the fused sagittal and axial volumes with parallel 3D encoders before decoding the combined representation into a report. Evaluated on three datasets, GateSPINE achieves the highest clinical efficacy F1 scores, improving recall across all datasets while remaining competitive on standard natural language generation metrics.

By Hoang Nguyen Van, Cuong Vuong Tuan, Trang Mai Xuan, Bien Tran Van, Nam Tran Van, Thien Van Luong