arXiv Machine Learning

Pretreatment MRI reveals a latent, molecular-subtype-independent structural phenotype that organizes treatment trajectories and recurrence risk

arXiv:2607. 02768v1 Announce Type: cross Abstract: Pathologic complete response and tumor shrinkage measure whether breast cancer responds to neoadjuvant therapy, but not whether that response was structurally favorable, persistent, or hidden beneath volume loss.

arXiv Machine Learning
Jul 16

Multimodal Empirical Bayes Variational Autoencoders for Joint Longitudinal and Time-to-Event Modeling

arXiv:2607. 13984v1 Announce Type: cross Abstract: Longitudinal tumor measurements, dropout information, and genetic covariates provide complementary information about treatment response, but integrating these data sources within a single population modeling framework remains challenging.

By Anders Sj\"oberg, Nils Olsson, Marcus Baaz, Mats Jirstrand
arXiv AI
Aug 5

Spatial proteomics guided by H&E-based AI reveals recurrence-risk niches in triple-negative breast cancer

arXiv:2608. 03145v1 Announce Type: new Abstract: Deep learning models can predict cancer recurrence from H&E stained slides, but the localized molecular states underlying these predictions remain largely obscured.

By Yesung Cho, Ji Hwan Park, Chanil Kim, Hyewon Kim, Honglan Li, Yumin Lee, Geongyu Lee, Sujeong Hong, Seong Min Park, Yoonyoung Lee, Hee Sool Rho, Sumin Lee, Amos Chungwon Lee, Changhwan Lee, Hwanyoung Shim, Hyunwook Kim, Hyeji Shin, Sanha Park, Jihoon Yu, Yoon Hee Shin, Sooheon Kim, Hyunjin Park, Seung Min Park, Sangwan Kim, Yujung Kim, Sung-Im Do, Eun-Young Kim, Dongmyung Shin, Jongbae Park, In-Gu Do
arXiv Machine Learning
Aug 26

A Multimodal Foundation Model for Longitudinal Patient Representation and Scalable Insight Generation in Oncology

arXiv:2608.24688v1 Announce Type: new Abstract: Precision oncology necessitates a longitudinal model of patient state that captures cancer evolution and treatment over time, integrating multimodal ob...

By Eugene Vorontsov, Yi Kan Wang, Alican Bozkurt, Adam Casson, Ludmila Tydlitatova, Michal Zelechowski, Ezra E. W. Cohen, Jyoti D. Patel, Max Banaszak, Caitlin McWilliams, Shane Colley, Kate Sasser, Ryan Fukushima, Eric Lefkofsky, Razik Yousfi, Siqi Liu
arXiv Computer Vision
Sep 23

Neoadjuvant chemotherapy response prediction using pretreatment diffusion and contrast-enhanced magnetic resonance imaging with clinical variables

arXiv:2609.26105v1 Announce Type: cross Abstract: Prediction of pathological complete response before neoadjuvant chemotherapy may facilitate more tailored therapeutic planning for breast cancer pati...

By Pablo Garc\'ia Marcos, Paula Puerta Gonz\'alez, Guillermo Lorenzo, H\'ector G\'omez, Covadonga del Camino, Ad\'an Rodr\'iguez, Ignacio Pel\'aez, Angel Rio-Alvarez, V\'ictor M. Gonz\'alez
arXiv Machine Learning
Sep 23

Foundation model embeddings capture pre-diagnostic changes on screening mammograms

The study examined whether embeddings from four foundation models—Mammo-CLIP, HOPPR, MedImageInsight, and BiomedCLIP—could detect pre‑diagnostic changes in screening mammograms. Using 1,773 biopsied women and matched controls, the researchers measured the speed of movement along a data‑derived “cancer direction” in embedding space over successive screening intervals. They found that embeddings from clinically grounded models (Mammo‑CLIP, HOPPR, MedImageInsight) showed faster drift in malignant cases compared to controls, while the general biomedical model BiomedCLIP did not, indicating that foundation model embeddings can encode early tissue changes without task‑specific fine‑tuning.

By Kalina P. Slavkova, Eric Brattain, Aditya Gowd, Akash Pattnaik, Jean-Benoit Delbrouck, Matthew Morgan, Julie Bauml, Javid Abderezaei, Khan Siddiqui
arXiv AI
Jun 19

The MAMA-MIA Challenge: Advancing Generalizability and Fairness in Breast MRI Tumor Segmentation and Treatment Response Prediction

arXiv:2603. 01250v2 Announce Type: replace-cross Abstract: Breast cancer is the most frequently diagnosed malignancy among women worldwide and a leading cause of cancer-related mortality.

By Lidia Garrucho, Smriti Joshi, Kaisar Kushibar, Richard Osuala, Maciej Bobowicz, Xavier Bargall\'o, Paulius Jaru\v{s}evi\v{c}ius, Kai Geissler, Raphael Sch\"afer, Muhammad Alberb, Tony Xu, Anne Martel, Daniel Sleiman, Navchetan Awasthi, Hadeel Awwad, Joan C. Vilanova, Robert Mart\'i, Daan Schouten, Jeong Hoon Lee, Mirabela Rusu, Eleonora Poeta, Luisa Vargas, Eliana Pastor, Maria A. Zuluaga, Jessica K\"achele, Dimitrios Bounias, Alexandra Ertl, Katarzyna Gwo\'zdziewicz, Maria-Laura Cosaka, Pasant M. Abo-Elhoda, Sara W. Tantawy, Shorouq S. Sakrana, Norhan O. Shawky-Abdelfatah, Amr Muhammad Abdo-Salem, Androniki Kozana, Eugen Divjak, Gordana Ivanac, Katerina Nikiforaki, Michail E. Klontzas, Rosa Garc\'ia-Dosd\'a, Meltem Gulsun-Akpinar, O\u{g}uz Lafc{\i}, Carlos Mart\'in-Isla, Oliver D\'iaz, Laura Igual, Karim Lekadir
arXiv Computer Vision
Aug 25

Tumor-aware augmentation with task-guided attention analysis improves rectal cancer segmentation from magnetic resonance images

arXiv:2605.05522v3 Announce Type: replace-cross Abstract: Although self-supervised pretraining is expected to learn broadly transferable representations, its effectiveness across imaging modalities s...

By Aneesh Rangnekar, Joao Miranda, Natally Horvat, Stephanie Chahwan, Samir Alrayess, Aditya Apte, Aditi Iyer, Eve LoCastro, Revathi Ravella, Marc J Gollub, Iva Petkovska, Jesse Joshua Smith, Paul Romesser, Julio Garcia-Aguilar, Harini Veeraraghavan, Joseph O Deasy
arXiv Computer Vision
Sep 23

Radiomics--Foundation Fusion for Interpretable RCC Classification: Internal Benchmarking and Exploratory External Transfer

arXiv:2609.26578v1 Announce Type: new Abstract: Accurate preoperative subtype classification of renal cell carcinoma (RCC) from contrast-enhanced CT remains clinically challenging because clear cell...

By Yuan Liang, Fangyijie Wang, Kathleen M. Curran, Gu\'enol\'e Silvestre, Sourav Bhattacharjee, Abraham Campbell
arXiv AI
Jun 17

Probing, Fusion, and Trustworthiness: A Systematic Evaluation of Foundation Model Representations for Multimodal Cancer Analysis

arXiv:2606. 17115v1 Announce Type: cross Abstract: Foundation models (FMs) have emerged as powerful representation extractors for medical data, yet their generalizability to datasets under distribution shift remains underexplored.

By Jingyu Hu, Giuseppe Tripodi, Reed Naidoo, Sarah F. McGough, Tapabrata Chakraborti