arXiv:2603. 24025v2 Announce Type: replace Abstract: Unsupervised learning of high-dimensional data is challenging due to irrelevant or noisy features obscuring underlying structures.
arXiv:2606. 14592v1 Announce Type: cross Abstract: Clustering is widely used for exploratory analysis and scientific discovery, driving insights from market segmentation to biological data analysis, but its outputs can be difficult to interpret, audit, and reproduce as modern datasets become increasingly large and complex.
arXiv:2512. 17678v2 Announce Type: replace-cross Abstract: Selecting compact and informative gene subsets from single-cell transcriptomic data is essential for biomarker discovery, improving interpretability, and cost-effective profiling.
arXiv:2509. 25289v4 Announce Type: replace-cross Abstract: Identifying an effective clustering algorithm for a given dataset remains a fundamental unsupervised learning issue.
The paper introduces Inverted Contrastive Learning for Unsupervised Feature Selection (ICLFS), a method that treats each feature as a sample by inverting the data matrix and applies a contrastive learning framework to learn consistent representations across masked positive views and a shuffled negative view. Feature saliency is derived from the magnitude of projector‑space embeddings, and a Laplacian‑Gated Ranking Correction step refines the ranking by reducing local redundancy. Experiments on 12 benchmark datasets show that ICLFS achieves the best clustering accuracy on 10 datasets compared to both classical and neural baselines, demonstrating the effectiveness of feature‑wise contrastive consistency for unsupervised feature selection.
CellMSA introduces a novel single‑cell representation learning framework that leverages a multiple‑sequence‑alignment‑inspired context model. For each target cell, it retrieves relevant cells across batches and related cell types, summarizing cross‑cell patterns into a context‑dependent gene‑pair representation that is fed into a pair‑aware encoder. Pretraining on a massive human single‑cell corpus (≈109 million cells) and subsequent benchmarks demonstrate consistent performance gains over existing methods.
arXiv:2105. 07610v5 Announce Type: replace-cross Abstract: Building trustworthy machine learning algorithms for biological applications requires adapting to data heterogeneity from different sources, batches, distributions, or studies.
arXiv:2606. 04665v1 Announce Type: new Abstract: Deep unsupervised domain adaptation (Deep UDA) methods successfully leverage rich labeled data in a source domain to boost the performance on related but unlabeled data in a target domain.
arXiv:2606. 05139v1 Announce Type: new Abstract: The rapid advancement of high-throughput sequencing has led to large, high-dimensional omics datasets.
arXiv:2603. 15263v2 Announce Type: replace-cross Abstract: Self-supervised learning (SSL) has revolutionized representation learning, with Joint-Embedding Architectures (JEAs) emerging as an effective approach for capturing semantic features.
arXiv:2609.14882v1 Announce Type: cross Abstract: Nucleotide sequence analysis is central to problems spanning regulatory genomics, evolutionary biology, and phenotype prediction. Classical bioinform...
arXiv:2606. 13007v1 Announce Type: cross Abstract: Clustering is fundamental to scRNA-seq analysis, serving as a cornerstone for identifying cell populations and resolving tissue heterogeneity.
The paper introduces a selective inference framework tailored for deep clustering that uses a fixed pretrained encoder to map high‑dimensional data into a latent space before clustering. It addresses the complex selection bias arising from the nonlinear transformation and offers a computationally tractable method to perform valid statistical tests on cluster differences. Experiments on synthetic data show controlled Type I error and higher power compared to conservative baselines, while genomic case studies demonstrate the ability to uncover significant cluster differences while properly accounting for selection bias.