Pathological diagnosis is inherently multi-scale, requiring the integration of global tissue architecture at low magnification with cellular morphology at higher magnification. However, existing pathology benchmarks and vision-language models (VLMs) are still largely developed under single-scale settings, limiting their ability to learn clinically meaningful multi-magnification reasoning.
arXiv:2606. 17412v1 Announce Type: cross Abstract: Pathological images are inherently multi-scale, requiring pathologists to integrate evidence from global tissue architecture at low magnification to cellular morphology at higher magnification for accurate diagnosis.
By Chi Phan, Tianyi Zhang, Qiaochu Xue, Yufeng Wu, Dan Hu, Zeyu Liu, Sudong Wang, Yueming Jin
arXiv:2606. 12169v1 Announce Type: cross Abstract: High-stakes clinical use of large vision-language models (LVLMs) requires reasoning that is grounded in visual evidence and clinical knowledge, not just correct final answers.
By Negin Baghbanzadeh, Pritam Sarkar, Michael Colacci, Abeer Badawi, Adibvafa Fallahpour, Arash Afkanpour, Leonid Sigal, Ali Etemad, Elham Dolatabadi
arXiv:2607. 04344v1 Announce Type: cross Abstract: While Large Vision-Language Models (VLMs) demonstrate remarkable generic capabilities, their clinical reasoning in specialized domains like ocular surface diseases (OSDs) is severely hindered by a paucity of high-fidelity, multimodal instruction-tuning data.
By Hao Wei, Wenjin Qi, Dasen Dai, Minqing Zhang, Wu Yuan
The paper introduces MedREAL, a unified framework that aligns linguistic reasoning with spatial grounding for medical visual question answering and segmentation. MedREAL employs Seg Anchored Reasoning Pooling (SARP) to extract semantic evidence from segmentation tokens and a Reasoning-to-Visual (R2V) fusion mechanism to integrate these features into a segmentation pipeline. Using the newly created MedRAVS-13K dataset, MedREAL achieves superior performance, reporting 68.49% gIoU and 70.47% cIoU, and generates evidence masks that consistently match textual diagnoses.
By Haowen Gu, Gensheng Pei, Junzhu Mao, Qiong Wang, Mingwu Ren, Yazhou Yao
arXiv:2607. 19261v1 Announce Type: cross Abstract: Whole-slide image (WSI) diagnosis requires identifying diagnostically relevant regions, examining them across magnifications, and integrating multi-scale evidence.
By Dankai Liao, Tianyi Zhang, Yufeng Wu, Xinyue Zhang, Qiaochu Xue, Zeyu Liu, Dachun Zhao, Linghan Cai, Yueming Jin
arXiv:2609.32352v2 Announce Type: replace-cross
Abstract: Vision-language models (VLMs) have shown increasing potential for medical image understanding, yet their capabilities in ophthalmic imaging r...
By Gujie Shao, Zixun Xie, Xuechun Xing, Ruixiang Wang, Ziyun Lan, Yanlin Qi, Gangyi Zhang, Yuxin Yang, Dawei Li, Haiming Tang
arXiv:2512. 11995v2 Announce Type: replace-cross Abstract: While many vision-language models (VLMs) are developed to answer well-defined, straightforward questions with highly specified targets, as in most benchmarks, they often struggle in practice with complex open-ended tasks, which usually require multiple rounds of exploration and reasoning in the visual space.
By Chenrui Fan, Yijun Liang, Shweta Bhardwaj, Kwesi Cobbina, Ming Li, Tianyi Zhou
arXiv:2609.37283v1 Announce Type: new
Abstract: Medical multimodal large language models (MLLMs) are increasingly expected not only to answer clinical questions, but also to localize the visual evide...
By Xuyang Cao, Enyou Liu, Jun Zhao, Zhuoyun Liu, Jintao Fei, Leo
arXiv:2604. 09757v2 Announce Type: replace-cross Abstract: Medical vision--language models (VLMs) have shown strong potential for medical visual question answering (VQA), yet their reasoning remains largely text-centric: images are encoded once as static context, and subsequent inference is dominated by language.
By Suyang Xi, Songtao Hu, Yuxiang Lai, Wangyun Dan, Yaqi Liu, Shansong Wang, Xiaofeng Yang
LiteMedCoT-VL is a parameter‑efficient pipeline that transfers chain‑of‑thought reasoning from a 235B teacher model to a 2B student model using LoRA fine‑tuning on explanation‑enriched data. The approach enables a compact vision‑language model to perform medical visual question answering without relying on image captions, achieving 64.9% accuracy on the PMC‑VQA benchmark—an 11‑point improvement over the zero‑shot Qwen3‑VL‑4B baseline. Visual grounding analysis confirms that the model bases its predictions on image content rather than textual priors.
By Runze Ma, Shunbo Jia, Haonan Lyu, Guo Liu, Caizhi Liao
arXiv:2511. 18676v2 Announce Type: replace-cross Abstract: Current vision-language models (VLMs) in medicine are primarily designed for categorical question answering (e.
By Yongcheng Yao, Yongshuo Zong, Raman Dutt, Yongxin Yang, Sotirios A Tsaftaris, Timothy Hospedales