The paper introduces Locked Image Multiple Instance PreTraining (LIMIT), a method that aligns slide‑level pathology reports with patch‑level visual features by freezing a vision encoder and fine‑tuning a text encoder. LIMIT uses report embeddings as cross‑attention queries over bags of patch features, optimizing slide representations via InfoNCE. Applying LIMIT, the authors create CONCH‑Z, which achieves state‑of‑the‑art zero‑shot performance on 22 pathology tasks, outperforming vision‑language encoders trained on curated caption datasets and narrowing the gap with larger slide‑level foundation models.
By Daniel Shao, Dongmin Bang, Luca L. Weishaupt, Sophia J. Wagner, Nic G. Reitsam, Ming Y. Lu, Long P. Le, Richard J. Chen, Faisal Mahmood
arXiv:2608.21300v1 Announce Type: new
Abstract: Foundation models for medical image segmentation, like prompt-based MedSAM, generalize well across domains and modalities, often in zero or few-shot se...
By Marko Haralovi\'c, Sounic Akkaraju, Carlo Baretta, Vasil Zapryanov, Alexia Briassouli
PathLang is a new, language‑centered benchmark for vision‑language models in computational pathology. It keeps the underlying pathology slides, ground‑truth labels, and image‑text evaluation direction constant while systematically varying the diagnostic language used in prompts, reflecting how pathologists actually rephrase diagnoses. The benchmark covers four task families—zero‑shot classification with image‑text alignment, cross‑modal retrieval, paraphrase robustness, and open‑vocabulary diagnosis retrieval—and evaluates nine VLMs across five public datasets spanning four organs.
By Fanqi Cheng, Kuo Gong, Shangke Liu, Beidi Zhao, Junchao Zhu, Zheyu Zhu, Leiyue Zhao, Fengbei Liu, John Cannon, Gang Wang, Zu-hua Gao, Kenji Ikemura, Yihe Yang, Yaohong Wang, Yuankai Huo, Xiaoxiao Li, Mert R. Sabuncu, Ruining Deng
arXiv:2605. 30716v2 Announce Type: replace-cross Abstract: Generating clinically useful pathology reports for pathology cases from whole-slide images (WSIs) is challenging due to gigapixel resolution, long visual-token sequences, and the complexity of case-level reasoning, where a single case may contain multiple WSIs with heterogeneous tissues and ambiguous findings.
By Zhiyuan Yang, Jiahao Cheng, Vincent Quoc-Huy Trinh, Mahdi S. Hosseini
HERO (Histology Encoder for Robust Representation in Oncology) is a ViT‑G/14 pathology foundation model trained with DINO and iBOT objectives and refined using high‑resolution Gram anchoring on a 500‑million‑tile corpus from about 575,000 clinical whole‑slide images. It demonstrates superior robustness to center, scanner, and stain variation compared to other state‑of‑the‑art foundation models, while maintaining competitive performance on tile‑level classification, segmentation, and gene‑expression prediction. Across 39 slide‑level clinical tasks, HERO ranks first on average and achieves the best average rank across six benchmark frameworks under an equal‑weighted analysis.
By Zhi Li (Caris Life Sciences, Irving, TX, United States), Eghbal Amidi (Caris Life Sciences, Irving, TX, United States), Yating Cheng (Caris Life Sciences, Irving, TX, United States), Tyson Dawson (Caris Life Sciences, Irving, TX, United States), Gorkem Can Ates (Caris Life Sciences, Irving, TX, United States), Shuzhen Kuang (Caris Life Sciences, Irving, TX, United States), Norsang Lama (Caris Life Sciences, Irving, TX, United States), Md Ashequr Rahman (Caris Life Sciences, Irving, TX, United States), Zhiying Lu (Caris Life Sciences, Irving, TX, United States), Elisabeth K. Kong (Caris Life Sciences, Irving, TX, United States), Milan Radovich (Caris Life Sciences, Irving, TX, United States), David Spetzler (Caris Life Sciences, Irving, TX, United States), Matthew Oberley (Caris Life Sciences, Irving, TX, United States), George W. Sledge (Caris Life Sciences, Irving, TX, United States), Ming Chen (Caris Life Sciences, Irving, TX, United States)
arXiv:2610.14226v1 Announce Type: cross
Abstract: Purpose : To develop and evaluate CAPTOR, a deep-learning vision-language foundation model for oncologic chest-abdomen-pelvis (CAP) CT interpretation...
By S\'el\'ena Jean-Mactoux, Sophie Loizillon, Ghina Jardali, Amandine Cromb\'e, Nathalie Lassau, Alexandre B\^one
arXiv:2608. 05960v1 Announce Type: cross Abstract: Routine CT interpretation is inherently comprehensive, capturing incidental findings across the entire scan volume.
By Maulik Chevli, Johannes Brandt, Rickmer Braren, Daniel Rueckert, Philip M\"uller
The paper presents a method for adapting a single vision‑language model, Qwen3.5‑9B, to medical image parsing tasks by using task‑specific low‑rank adapters (LoRA) selected from the input question. The system employs a frozen 4‑bit backbone and customizes adapter ranks, prompts, and class rebalancing across six task families and seven imaging modalities, achieving strong performance on the FLARE 2026 Task 3 dataset and a hidden‑validation set. The authors provide code and demonstrate that task‑specific adapter configurations and image budgets improve performance across diverse medical imaging tasks.
By Taha Sabir, Alberto Montero Molina, Thinh Quang Ly, Veronika Dmitrenko, Mohammad Yaqub, Tausifa Jan Saleem
The paper introduces Expandable Modality Experts, a medical vision‑language framework that uses an expandable bank of modality experts and a Multiway Transformer to combine shared visual computation with deterministic routing and a separate text pathway. It employs a modality‑aware visual tokenizer for masked pretraining on 19.4 million unpaired image rows across seven modalities, followed by contrastive alignment on 3.23 million image‑text pairs. With a ViT‑Large backbone, the method achieves state‑of‑the‑art results in 24 of 25 benchmark settings across nine modalities, including zero‑shot classification, linear probing, and retrieval tasks, while preserving existing representations.
By DM BAPPY, Eunsu Kim, Hanjoo Lee, Sung Hak Lee, Sangjeong Ahn
arXiv:2603. 19957v2 Announce Type: replace-cross Abstract: Pathology reports are structured, multi-granular documents encoding diagnostic conclusions, histological grades, and ancillary test results across one or more anatomical sites; yet existing pathology vision-language models (VLMs) reduce this output to a flat label or free-form text.
By Ruicheng Yuan, Zhenxuan Zhang, Anbang Wang, Liwei Hu, Xiangqian Hua, Yaya Peng, Jiawei Luo, Guang Yang
LanGuSTE is a patch‑selection framework for whole slide image analysis that uses vision‑language models and large language model knowledge. It introduces Cross‑Scale Visual Prompt Tuning to align low‑resolution and high‑resolution patches, and a coarse‑to‑fine selection module that encodes only informative high‑resolution patches. Experiments show LanGuSTE cuts overall processing time to about one‑third of the baseline while matching or surpassing diagnostic performance of exhaustive and state‑of‑the‑art methods.
By Yonghan Shin, Gangsu Kim, Won-Ki Jeong
Pathology vision-language models (VLMs) have recently progressed rapidly and are commonly evaluated by answer accuracy on pathology VQA benchmarks. However, we dig into current evaluations and identify three overlooked issues: 1) Visual evidence is not always necessary.