When Adaptation Hurts: Connecting Representational Drift to OOD Failures in MedSAM Fine-Tuning
Read the original on arXiv Computer Vision →The Flow has not summarised this story yet — read it at arXiv Computer Vision.
The Flow has not summarised this story yet — read it at arXiv Computer Vision.
Lumen is a pathology vision‑language model that aligns frozen unimodal foundation models (Virchow2 and BioMedBERT) using rank‑4 adapters and projection heads, training only 0.40% of the total parameters on the QUILT‑1M corpus. It achieves the highest mean chance‑corrected balanced accuracy (0.546) across nine zero‑shot patch benchmarks and demonstrates strong performance on lymph‑node metastasis detection, with AUROC scores of 0.964 internally and 0.955 externally. While it ranks third in cross‑modal retrieval, Lumen’s low‑parameter training yields competitive results at both patch and slide levels.
The paper introduces TopKSigLIP, a vision‑language model tailored for mammography that tackles two key challenges: high‑resolution imaging and homogeneous radiology reports. It replaces standard CLIP training with a TopK‑Patch module that selects sparse high‑resolution patches likely to contain lesions, and a Sup‑sigmoid loss that uses soft labels from structured data instead of contrastive loss. TopKSigLIP outperforms existing open‑source mammography and general medical VLMs on zero‑shot tasks such as density assessment, BI‑RADS classification, finding subtyping, and cancer prediction, while also providing better lesion localization than Grad‑CAM.
arXiv:2607. 09562v1 Announce Type: cross Abstract: Medical Vision-Language Models (VLMs) exhibit strong zero-shot performance, yet their effectiveness still declines on out-of-distribution (OOD) data due to domain shifts and class bias inherited from large-scale pretraining.
The paper evaluates federated learning with Low‑Rank Adaptation (LoRA) for fine‑tuning the BiomedCLIP vision‑language model on chest X‑ray classification across four international cohorts. Federated LoRA improves shared‑class AUC from 0.687 to 0.802, outperforming isolated single‑cohort training and approaching a centralized reference. The study shows that SVD‑based product‑space aggregation (FlexLoRA) is crucial for performance, while FedProx offers no advantage over FedAvg in this setting.
arXiv:2607. 10358v1 Announce Type: cross Abstract: Foundation models are increasingly used as image feature extractors for mammography, but their robustness under external domain shift remains unclear.
arXiv:2606. 04922v1 Announce Type: cross Abstract: Current prompt-based and adapter-based tuning of vision-language models (VLMs) is attractive for medical imaging, where clinical data sensitivity favors frozen backbones and annotations are limited.