arXiv Computer Vision
Sep 17

Lumen: Parameter-Efficient Alignment of Pretrained Vision and Language Encoders for Zero-Shot Computational Pathology

Lumen is a pathology vision‑language model that aligns frozen unimodal foundation models (Virchow2 and BioMedBERT) using rank‑4 adapters and projection heads, training only 0.40% of the total parameters on the QUILT‑1M corpus. It achieves the highest mean chance‑corrected balanced accuracy (0.546) across nine zero‑shot patch benchmarks and demonstrates strong performance on lymph‑node metastasis detection, with AUROC scores of 0.964 internally and 0.955 externally. While it ranks third in cross‑modal retrieval, Lumen’s low‑parameter training yields competitive results at both patch and slide levels.

By Kiarash Tajbakhsh, Abdelrahman Faqieh, Michael Jopiti, Javier Garcia-Baroja, Philipp Zens, Branislav Zagrapan, Yuri Tolkach, Martin D. Berger, Aurel Perren, Bastian Dislich, Inti Zlobec, Amjad Khan
arXiv Computer Vision
Sep 4

Solving the Needle-in-a-Haystack Problem in Mammography Vision-Language Model with Differentiable Subset Sampling

The paper introduces TopKSigLIP, a vision‑language model tailored for mammography that tackles two key challenges: high‑resolution imaging and homogeneous radiology reports. It replaces standard CLIP training with a TopK‑Patch module that selects sparse high‑resolution patches likely to contain lesions, and a Sup‑sigmoid loss that uses soft labels from structured data instead of contrastive loss. TopKSigLIP outperforms existing open‑source mammography and general medical VLMs on zero‑shot tasks such as density assessment, BI‑RADS classification, finding subtyping, and cancer prediction, while also providing better lesion localization than Grad‑CAM.

By Young Seok Jeon, Beatrice Brown-Mulry, Rohan Satya Isaac, Anjana Dissanayaka, Theo Dapamede, Mohammadreza Chavoshi, Judy Gichoya, Hari Trivedi
arXiv AI
Sep 3

Federated LoRA Adaptation of BiomedCLIP Across Four International Chest X-Ray Cohorts

The paper evaluates federated learning with Low‑Rank Adaptation (LoRA) for fine‑tuning the BiomedCLIP vision‑language model on chest X‑ray classification across four international cohorts. Federated LoRA improves shared‑class AUC from 0.687 to 0.802, outperforming isolated single‑cohort training and approaching a centralized reference. The study shows that SVD‑based product‑space aggregation (FlexLoRA) is crucial for performance, while FedProx offers no advantage over FedAvg in this setting.

By Sanjaya Poudel, Nirajan Kunwor, Manish Dhakal, Debesh Jha, Sunil Kumar Gaire