Vision-language pre-training (VLP) holds great promise for general-purpose medical AI by leveraging radiology reports as rich textual supervision, yet existing methods struggle with 3D CT imaging due to inefficient visual backbones and coarse semantic alignment. To address these issues, we propose a tailored VLP framework featuring three key components: (1) a CNN-ViT hybrid encoder that replaces ViT's patch embedding with a 3D CNN backbone to efficiently capture local anatomical details while preserving global attention and compatibility with pre-trained cross-modal priors; (2) a disease-level contrastive learning mechanism using learnable query tokens to dynamically extract disease-specific semantics from full reports and align them with corresponding visual features, thereby disentangling distinct diseases within the same anatomical region; and (3) a diagnosis-aware prompt strategy that employs real clinical phrases and aggregated disease prototypes to bridge the pre-training-inference gap and enhance zero-shot diagnostic reliability.
arXiv:2605. 30716v2 Announce Type: replace-cross Abstract: Generating clinically useful pathology reports for pathology cases from whole-slide images (WSIs) is challenging due to gigapixel resolution, long visual-token sequences, and the complexity of case-level reasoning, where a single case may contain multiple WSIs with heterogeneous tissues and ambiguous findings.
By Zhiyuan Yang, Jiahao Cheng, Vincent Quoc-Huy Trinh, Mahdi S. Hosseini
arXiv:2606. 06983v1 Announce Type: cross Abstract: Computational pathology requires visual representations that transfer across diverse clinical endpoints and remain robust to variation in magnification, staining, scanner type, slide preparation, and input resolution.
By Bokai Zhao, Yiyang Zhang, Long Bai, Tai Ma, Hanqing Chao, Minfeng Xu
arXiv:2608. 04472v1 Announce Type: cross Abstract: The development of foundation models (FMs) is crucial for advancing endoscopic image analysis.
By Zhenyu Yi, Jianwei Xu, Yue Hu, Zhongwei Qiu, Sijing Li, Liang Huang, Bin Lv, Ling Zhang, Yingda Xia
Pathology vision-language models (VLMs) have recently progressed rapidly and are commonly evaluated by answer accuracy on pathology VQA benchmarks. However, we dig into current evaluations and identify three overlooked issues: 1) Visual evidence is not always necessary.
arXiv:2508. 16674v2 Announce Type: replace-cross Abstract: Medical report understanding from real-world document images is essential for generating patient-facing explanations and enabling structured information exchange in clinical systems.
By Fangxin Shang, Yuan Xia, Dalu Yang, Yahui Wang, Binglin Yang