The paper presents the first systematic evaluation of out‑of‑distribution generalization for congenital heart disease (CHD) segmentation, using the ImageCHD cohort as a held‑out target. It compares several segmentation architectures under different training regimes, showing that in‑distribution performance is a poor predictor of cross‑cohort robustness: nnU‑Net drops from 0.77 to 0.51 Dice, while SwinUNETR maintains higher performance at 0.67 Dice. Limited target‑domain adaptation with only 11 labeled ImageCHD cases boosts all SwinUNETR variants above 0.76 Dice, highlighting the importance of explicit cross‑dataset testing.
By Aniketh Vijesh, Shrisharanyan Vasu, Abhijit Ramesh, Clare Pomeroy-Ward, Harikrishnan Anil Maya, Sarin Xavier, Mahesh Kappanayil, Gilad Gressel
Congenital heart disease (CHD) diagnosis and surgical planning often require patient-specific 3D anatomical models, but manual segmentation is labor-intensive, particularly in complex anatomies. Altho...
arXiv:2605. 16427v2 Announce Type: replace-cross Abstract: Deep learning models for echocardiography segmentation often struggle to generalise across institutions, scanners, and patient populations, where collecting large, consistently annotated datasets is infeasible.
By Soroush Elyasi, Sara Adibzadeh, Nasim Dadashi Serej, Massoud Zolgharni
arXiv:2606. 15837v1 Announce Type: cross Abstract: Deep neural networks (DNNs) frequently fail to generalize to out-of-distribution (OOD) medical images because of variations in scanners and acquisition protocols.
By Jimut B. Pal, Suyash P. Awate
arXiv:2607. 11287v1 Announce Type: cross Abstract: Comprehensive quantification of cardiac structures from computed tomography (CT) remains limited not by data availability but by the scalability of measurements, which makes routine use impractical.
By Pooya Mohammadi Kazaj, Leo Fridolin Weber, Wen Xie, Seyed Amir Ahmad Safavi-Naini, Anselm Stark, Giovanni Baj, Ali Mokhtari, Toshiya Yoshida, Christoph Ryffel, Taishi Okuno, Yoshihiro Akashi, Ronny R. Buechel, Thomas Pilgrim, Waldo Valenzuela, George C. M. Siontis, Xiaowei Xu, Moritz Hundertmark, Stephan Windecker, Christoph Grani, Isaac Shiri
The paper introduces SV-Cine, a cardiac MRI segmentation framework tailored for single ventricle physiology (SVP). It combines a generative data augmentation pipeline that creates synthetic 3D cardiac meshes and MRI, with a diagnosis-conditioned adaptation of the CineMA foundation model that uses patient-level diagnostic information to improve segmentation. Evaluations on an internal cohort show high Dice scores for left and right ventricles, outperforming nnU-Net, and demonstrate that incorporating diagnosis priors can adapt a pretrained model to specialized SVP tasks.
By Lila Cunge, Yuehong Liu, Hang Xu, Thomas Coudert, Pierangelo Renella, J Paul Finn, William Hsu, Kim-Lien Nguyen
arXiv:2608. 03342v1 Announce Type: cross Abstract: Conditional segmentation models may be trained and evaluated with auxiliary signals cleaner than those available at deployment.
By Dang P. M. Cao, Hieu D. Pham, Hieu Pham
arXiv:2609.21412v1 Announce Type: new
Abstract: Medical image segmenters often get worse when sites, scanner vendors, or protocols change. Continual test-time adaptation (CTTA) addresses this problem...
By Ruijie Huang
arXiv:2608. 14766v1 Announce Type: cross Abstract: Uncertainty estimation is critical for the safe clinical deployment of deep learning in medical image segmentation, with aleatoric uncertainty theoretically designed to capture irreducible data ambiguity.
By Simon Baur, Arne Schernich, Ekin B\"oke, Wojciech Samek, Jackie Ma
arXiv:2608. 09460v1 Announce Type: new Abstract: Cardiac digital twin research is moving from subject-specific anatomical replicas toward virtual cohorts that represent clinically relevant population subgroups.
By Konstantinos Kevopoulos, Beatrice Moscoloni, Benjamin Alheit, Cameron Beeche, Julio A. Chirinos, Alexander Heinlein, Mathias Peirlinck
arXiv:2604. 15271v3 Announce Type: replace-cross Abstract: Reliable uncertainty estimation is critical for medical image segmentation, where automated contours feed downstream quantification and clinical decision support.
By Tianhao Fu, Austin Wang, Charles Chen, Roby Aldave-Garza, Yucheng Chen
The paper introduces the "segmentation ceiling," a quantitative criterion that determines when explicit left‑ventricular (LV) segmentation can improve ejection fraction (EF) regression. By deriving how per‑frame segmentation area error propagates into EF error, the authors find that a break‑even error of about 10% per frame is required, whereas typical segmenters exceed this threshold (~14%). Consequently, several strategies that incorporate segmentation or area information fail to outperform a raw‑video baseline, while techniques such as weight averaging with strong augmentation and a heteroscedastic beta‑NLL loss yield competitive EF predictions and well‑calibrated uncertainty estimates.
By Farshid Farhadi Khouzani, Paul La Plante, Bryar Mustafa Shareef, Laxmi Gewali