arXiv AI

Radiomics and artificial Intelligence for thyroid cancer diagnosis: Concepts, challenges, and solutions

This review examines the use of artificial intelligence and radiomics for diagnosing thyroid cancer, summarizing 42 studies that demonstrate the effectiveness of ultrasound-based radiomics in identifying malignancies. It highlights challenges such as interpretability, limited datasets, and operator dependence, and calls for standardization, prospective multicenter trials, and advances in explainable AI and personalized medicine. The authors emphasize that multidisciplinary collaboration and further algorithm refinement could enhance diagnostic accuracy and patient outcomes.

arXiv AI
Aug 14

Auditable agentic AI for evidence-grounded thyroid ultrasound diagnosis and reporting

arXiv:2608. 12590v1 Announce Type: new Abstract: Thyroid ultrasound diagnosis requires coordinated lesion localization, measurement, risk stratification and reporting, yet most AI systems address these tasks in isolation and provide limited support for clinical review.

By Haifan Gong, Shiyu Chen, Bodong Wang, Yuqi Wang, Shijie Wang, Guoliang You, Xinyu Xiong, Haowei Wang, Mingzhi Mao, Dexing Kong, Qinghua Liu, Wei Lou, Fei Chen, Guanbin Li
arXiv AI
Jul 15

Calibrated Selective Prediction Using Deep Ensembles for ROI-Based Thyroid Nodule Ultrasound Classification Under Dataset Shift: A Retrospective Evaluation

arXiv:2607. 12075v1 Announce Type: cross Abstract: Background: Deep learning models can classify thyroid nodules on ultrasound, but reliable clinical decision support also requires calibrated probabilities, uncertainty estimation, and selective referral, particularly under dataset shift.

By Md. Sadibul Hasan Sadib, Md. Mohayminul Mukit, Rahmatul Kabir Rasel Sarker, Tahmid Alam Tamim, Md. Monir Hossain Shimul
arXiv AI
Sep 16

A Vision-Language Foundation Model for Precise and Comprehensive Brain Tumor Diagnosis from Preoperative Multimodal Data

arXiv:2609.16597v1 Announce Type: cross Abstract: Background Non-invasive presurgical diagnosis of brain tumor types from Magnetic Resonance Imaging (MRI) is essential but challenging due to overlapp...

By Yinong Wang (Joyce), Jianwen Chen (Joyce), Zhou Chen (Joyce), Shuwen Kuang (Joyce), Haoning Jiang (Joyce), Yanzhao Shi (Joyce), Huichun Yuan (Joyce), Yan-ran (Joyce), Wang, Bing Wang, Lei Wu, Bin Tang, Li Meng, Baihua Luo, Bin Zhou, Wei Ding, Weiming Zhong, Wei Hou, Yuanbing Chen, Zhiping Wan, Wei Wang, Zhenkun Xiao, Wenwu Wan, Allen He, Yuyin Zhou, Longbo Zhang, Feifei Wang, Zhixiong Liu, Michael Iv, Xuan Gong, Liangqiong Qu
arXiv AI
Sep 1

Explainable Artificial Intelligence (XAI) in Computational Pathology: Definitions, Taxonomy, and Recommendations

arXiv:2608.28820v1 Announce Type: new Abstract: Computational pathology (CompPath) is transforming medicine by leveraging artificial intelligence (AI) algorithms to support diagnosis, prognosis, and...

By Shubham Innani, Suhang You, Adam Shephard, Bhakti Baheti, Francesco Ciompi, Joe Yeong, Nasir Rajpoot, Michael Feldman, Solene Florence Kammerer-Jacquet, Dimitrios Makris, Geert Litjens, Anne L. Martel, Jana Lipkova, April Khademi, Spyridon Bakas, for the MICCAI SIG-CompPath
arXiv AI
Aug 26

LUCAID: Agentic Multimodal AI for Lung Cancer Precision Pathology

LUCAID is an agentic multimodal AI system designed for precision lung cancer pathology, integrating nine modules that cover the entire routine workflow—from quality control and tumor detection to histological subtyping, microenvironment profiling, cellularity quantification, and biomarker scoring (PD‑L1, MET, TROP‑2). The system generates automated structured reports and allows interactive querying of module outputs. In prospective clinical validation, LUCAID achieved 93.0% concordance with an expert‑panel reference standard for clinically actionable decisions, outperforming five experienced thoracic pathologists who ranged from 68.3% to 81.1% concordance.

By Marie-Lisa Eich, Kai Standvoss, Timo Milbich, Alexander M\"ollers, Miriam H\"agele, Philipp Anders, Lars Tharun, Hanna Kontradiuk, Sebastian Kons, Nader Aldoj, Recepcan Adig\"uzel, Adam Narai, Lukas H\"onig, Jonathan Striebel, Binru Yang, Mihnea P. Dragomir, Marvin Sextro, Philipp Keyl, Philipp Jurmeister, Rosemarie Krupar, Evelyn Ramberger, James Wells, Julika Ribbat-Idel, Andreas Kunft, Hussam Shuaib, Christian Groh\'e, Reinhard B\"uttner, David Horst, Klaus-Robert M\"uller, Lukas Ruff, Maximilian Alber, Frederick Klauschen, Simon Schallenberg
arXiv AI
Aug 17

CMCNet: Aligning Ultrasound Image Embeddings with Textual TI-RADS Representations for Fine-Grained Thyroid Classification

arXiv:2608. 13939v1 Announce Type: cross Abstract: Ultrasound is the primary imaging modality for assessing thyroid nodules, and the ACR TI-RADS framework standardizes diagnosis through five ultrasound feature categories that are aggregated into five risk levels (TR1-TR5).

By Bingxin Yu, Xueli Wang, Jerry Zhou, Wenyan Wang, Li Wen, Lan Huang, Xin Feng, Fengfeng Zhou, Kewei Li
arXiv AI
Sep 10

A radiographic world model for clinical reasoning and evidence generation

The paper introduces MedDream, a radiographic world model that learns a shared continuous latent state from paired chest radiograph-text observations. MedDream outperforms existing diagnostic and generative AI models across eight clinical datasets, improving diagnostic reasoning, resident concordance, and evidence generation. Targeted synthetic augmentation guided by subgroup performance gaps further enhances model performance, particularly for Asian patients.

By Suyang Xi, Songtao Hu, Shansong Wang, Mojtaba Safari, Luke del Balzo, Ehsan Ul Karim, Mingzhe Hu, Kuo Zhang, Tonghe Wang, Ralph R. Weichselbaum, Xiaofeng Yang
arXiv AI
Jun 8

Evidence-Based Intelligent Diagnostic and Therapeutic Visualization System with Large Language Models: Multi-Turn Interaction and Multimodal Treatment Plan Generation

arXiv:2606. 06869v1 Announce Type: new Abstract: Aim: Existing AI-assisted traditional Chinese medicine diagnostic tools suffer from opaque reasoning processes, passive interaction, and limited treatment plan presentation.

By Yunhan Wang, Yuda Wang, Zhiying Tu, Mingqiang Song, Li Song, Kun Li, Dianhui Chu, Bolin Zhang
arXiv Computer Vision
Sep 23

Radiomics--Foundation Fusion for Interpretable RCC Classification: Internal Benchmarking and Exploratory External Transfer

arXiv:2609.26578v1 Announce Type: new Abstract: Accurate preoperative subtype classification of renal cell carcinoma (RCC) from contrast-enhanced CT remains clinically challenging because clear cell...

By Yuan Liang, Fangyijie Wang, Kathleen M. Curran, Gu\'enol\'e Silvestre, Sourav Bhattacharjee, Abraham Campbell
arXiv Machine Learning
Sep 25

TAM-Chain: Multi-Scale Thyroid Cytology Classification via Absorbing Markov Chains and Shannon Entropy Uncertainty Quantification for False-Negative Suppression and Domain-Shift Adaptation

TAM-Chain is a multi‑scale thyroid cytology classification framework that uses Absorbing Markov Chains and Shannon Entropy to quantify uncertainty and dynamically decide when to stop processing and refer to a specialist. It processes images at 10×, 20×, and 40× magnifications, achieving a Macro F1 score of 0.9741 on an internal test set with a 0 % false‑negative rate, and maintains a Macro F1 of 0.7026 on an external validation set with severe domain shift. The method outperforms single‑magnification baselines by adaptively adjusting stopping steps and triggering specialist referrals, thereby reducing critical diagnostic errors.

By Hai Pham Ngoc