arXiv Computer Vision By Laura Testa, Pierpaolo Brutti, Umberto Ferraro Petrillo

Radiomics-Based Thyroid Nodule Classification with Label-Conditional Conformal Prediction

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The paper presents a radiomics-based approach for classifying thyroid nodules using ultrasound images. It extracts quantitative features with PyRadiomics and employs a Generalized Additive Model (GAM) chosen for its balance of performance and interpretability, achieving an AUC of 0.89, sensitivity of 0.83, and specificity of 0.82 on a public dataset. To provide uncertainty estimates, Cross-Conformal Prediction with label-conditional guarantees is applied, allowing 63% of test nodules to receive a confident single-label prediction while the remaining 37% are referred to clinicians.

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