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arXiv AI
Aug 26

LUCAID: Agentic Multimodal AI for Lung Cancer Precision Pathology

LUCAID is an agentic multimodal AI system designed for precision lung cancer pathology, integrating nine modules that cover the entire routine workflow—from quality control and tumor detection to histological subtyping, microenvironment profiling, cellularity quantification, and biomarker scoring (PD‑L1, MET, TROP‑2). The system generates automated structured reports and allows interactive querying of module outputs. In prospective clinical validation, LUCAID achieved 93.0% concordance with an expert‑panel reference standard for clinically actionable decisions, outperforming five experienced thoracic pathologists who ranged from 68.3% to 81.1% concordance.

By Marie-Lisa Eich, Kai Standvoss, Timo Milbich, Alexander M\"ollers, Miriam H\"agele, Philipp Anders, Lars Tharun, Hanna Kontradiuk, Sebastian Kons, Nader Aldoj, Recepcan Adig\"uzel, Adam Narai, Lukas H\"onig, Jonathan Striebel, Binru Yang, Mihnea P. Dragomir, Marvin Sextro, Philipp Keyl, Philipp Jurmeister, Rosemarie Krupar, Evelyn Ramberger, James Wells, Julika Ribbat-Idel, Andreas Kunft, Hussam Shuaib, Christian Groh\'e, Reinhard B\"uttner, David Horst, Klaus-Robert M\"uller, Lukas Ruff, Maximilian Alber, Frederick Klauschen, Simon Schallenberg
agentscomputer-visionmultimodal
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arXiv AI
Oct 2

OpenMTB-Audit: Exposing Over-Refusal and Clinical Expert Perspectives in LLM-Based Molecular Tumor Board Safety Evaluation

OpenMTB‑Audit is an open‑source benchmark that tests large language models on 500 synthetic non‑small cell lung cancer cases, covering five adversarial error categories and four safety labels: Supported, Partially Supported, Unsupported, and Insufficient Information. The study found that all eight tested LLMs over‑refused Partially Supported recommendations, collapsing labels to achieve high safety scores. A deterministic seven‑module framework, MTB‑AuditAgent, was introduced to reduce over‑refusal to 6.7% and reach 91.2% accuracy, while an oncologist annotation study highlighted disagreement around the boundary between information sufficiency and treatment optimization.

By Negin Ashrafi, Jia Luo, Stacey M. Frumm, Roxana Daneshjou
llmsbenchmarkssafety
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arXiv AI
Sep 1

Explainable Artificial Intelligence (XAI) in Computational Pathology: Definitions, Taxonomy, and Recommendations

arXiv:2608.28820v1 Announce Type: new Abstract: Computational pathology (CompPath) is transforming medicine by leveraging artificial intelligence (AI) algorithms to support diagnosis, prognosis, and...

By Shubham Innani, Suhang You, Adam Shephard, Bhakti Baheti, Francesco Ciompi, Joe Yeong, Nasir Rajpoot, Michael Feldman, Solene Florence Kammerer-Jacquet, Dimitrios Makris, Geert Litjens, Anne L. Martel, Jana Lipkova, April Khademi, Spyridon Bakas, for the MICCAI SIG-CompPath
safety
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arXiv Computer Vision
3d ago

MedPAO-VL: Interpretable and Protocol-Compliant Agent for Structured Radiology Report Generation

MedPAO‑VL is a multimodal agent that generates structured radiology reports from chest X‑rays using an explainable plan‑act‑observe loop. The system first interprets the image with a vision module that captures diagnostic uncertainty, then iteratively refines the report by correcting semantic discrepancies to better match visual findings. Evaluation shows improved clinical correctness and structural compliance, with expert ratings of 3.5/5 for accuracy and 4.3/5 for structure.

By Shrish Shrinath Vaidya, Gowthamaan Palani, Minmini Selvam, Gokulraja Srinivasaraja, Ganapathy Krishnamurthi
llmsagentsmultimodalsafety
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