arXiv AI

Context-Aware Hierarchical Bayesian Modeling of IVF Laboratory Environmental Conditions

arXiv:2606. 20459v1 Announce Type: new Abstract: IVF pregnancy rates are routinely modeled using patient-level variables, while high-resolution laboratory environmental data remain underutilized.

arXiv AI
Jun 12

Is It You or Your Environment? A Bayesian Inference Framework for Genomically-Anchored Personalized Physiological Interpretation

arXiv:2606. 13556v1 Announce Type: new Abstract: Personalized health AI systems face a fundamental cold-start problem: machine learning models for physiological interpretation require weeks of individual behavioral data before they can distinguish constitutional variation from environmentally driven deviation.

By Aruna Dey, Suraj Biswas
arXiv Machine Learning
Sep 22

A Patient World Model for Early Forecasting of Digital Health Campaign Outcomes: Capabilities and Limits

The paper introduces a compact patient world model that forecasts digital health campaign outcomes by maintaining a latent state per patient and learning exposure‑conditioned dynamics. Evaluated on a large US campaign dataset, the model predicts new‑to‑brand prescription volume with low relative error (2.9% at week‑4 cutoff) compared to much higher errors from baseline classifiers. The study also shows that dense next‑exposure supervision is crucial for accurate forecasts when conversions are rare and highlights limitations in interpreting exposure‑conditioned rollouts causally.

By Yunlong Wang
arXiv AI
Sep 10

PGP-Clinical-TimeKAN: Prior-Guided Joint Probabilistic Forecasting of Clinical Trajectories

PGP-Clinical-TimeKAN is a trajectory-first framework for joint probabilistic forecasting of multivariate physiological data, combining missingness-aware temporal encoders, a soft organ-system prior, patient-specific relations, nonlinear Kolmogorov‑Arnold messages, and a low‑rank multivariate Student‑t head. Evaluated on a MIMIC‑IV cohort of 6,882 patients, it achieves the second‑lowest normalized MAE and the lowest RMSE among 13 models, while providing calibrated probabilistic forecasts with empirical coverage at 50%, 80%, and 95% intervals. Ablation studies show that relational structure is critical for performance, and increasing covariance rank improves likelihood but not point accuracy. whyItMatters":"The model demonstrates that joint trajectory forecasting can yield highly accurate, calibrated predictions of physiological trajectories, offering a potentially inspectable intermediate task for clinical deterioration prediction."

By Weizhi Nie, Rihao Chang, Weijie Wang, Yuting Su
arXiv Computation and Language
Aug 25

Scaling Electronic Health Record Foundation Models for Population Health Management

The paper introduces Scaling Electronic Health Record Foundation Models for Population Health Management, a large‑scale model trained on billions of medical events from over 5 million patients in Taiwan and the United States. By aligning ICD codes across different health systems, the model achieves strong scaling and generalization across 11 chronic disease prediction tasks, outperforming tree‑based, general, and biomedical language models with high sensitivity at 99% specificity. It also demonstrates superior few‑shot performance on the EHRShot benchmark and shows that cross‑system alignment provides a stronger pretraining signal than single‑site duplication in data‑limited scenarios.

By Liwen Sun, Hao-Ren Yao, Ophir Frieder, Xiang Qian, Chenyan Xiong