arXiv:2607. 11508v1 Announce Type: cross Abstract: Causal discovery, the process of recovering underlying causal structures from observational data, is a fundamental pursuit across scientific disciplines.
By Jie Qiao, Ruichu Cai, Zijian Li, Weilin Chen, Pengfei Hua, Boyan Xu, Zhengming Chen, Zhifeng Hao, Peng Cui
The paper introduces ePID, an embedding-based approach that scales partial information decomposition (PID) to large symptom networks by compressing non‑focal symptoms into a low‑cardinality discrete embedding. Using a supervised Agglomerative Conditional Information Bottleneck (ACIB) embedding, ePID accurately recovers source‑unique, remainder‑unique, redundant, and synergistic components for each ordered source‑target pair across 83 real‑world datasets, outperforming 12 other embeddings. Applied to PHQ‑9 and the Interpersonal Reactivity Index, ePID reveals distinct patterns of redundancy and synergy that align with each instrument’s construction, demonstrating its ability to separate overlapping from interaction‑dependent information in symptom networks.
By Cillian Hourican, Eric Dignum, Rick Quax, Debraj Roy
arXiv:2606. 00483v1 Announce Type: cross Abstract: Genotype-based cis-expression prediction depends on accurately modeling local regulatory architecture.
By Lei Huang, Hui Shen, Kuan-Jui Su, Chuan Qiu, Martha Isabel Gonzalez-Ramirez, Anqi Liu, Zhe Luo, Yun Gong, Yipu Zhang, Dawei Li, Chaoyang Zhang, Hong-Wen Deng
arXiv:2606. 18535v1 Announce Type: cross Abstract: Multi-cause observational studies contain information about unmeasured confounding through the dependence structure among causes.
By Yordan P. Raykov, Hengrui Luo, Justin D. Strait, Wasiur R. KhudaBukhsh
The paper introduces a method for estimating the causal effects of T cell receptor (TCR) sequences on patient outcomes using observational TCR sequencing and clinical data. It corrects for unobserved confounders by leveraging the pre-selection TCR repertoire generated through V(D)J recombination as a natural experiment, and employs permutation‑invariant neural networks to scale to millions of sequences. The approach is validated on semisynthetic data and applied to COVID‑19 severity, identifying TCRs that are observed in patients, bind SARS‑CoV‑2 antigens in vitro, and positively influence clinical outcomes.
By Eli N. Weinstein, Elizabeth B. Wood, David M. Blei
arXiv:2601. 14590v3 Announce Type: replace Abstract: Counterfactual explanations (CFEs) provide human-centric interpretability by identifying the minimal, actionable changes required to alter a machine learning model's prediction.
By Shovito Barua Soumma, Asiful Arefeen, Stephanie M. Carpenter, Melanie Hingle, Hassan Ghasemzadeh