arXiv Machine Learning

Graph-Based Approaches to Learning Epileptogenic Zone Localization Using Stereo-EEG Recordings

The study evaluates how different graph topologies influence the localization of the epileptogenic zone (EZ) from resting‑state stereo‑EEG recordings in 40 patients. Using a consistent learning model and leave‑one‑patient‑out validation, the authors compare dense graphs, anatomy‑ and geometry‑informed priors, budgeted sparsification, learned sparsification, and a new Region‑Bridge‑c topology. At about 30% edge retention, Region‑Bridge‑c achieves the highest mean PR‑AUC and ROC‑AUC while using roughly 69% fewer edges than a dense graph, indicating that graph construction significantly impacts EZ localization performance.

arXiv AI
4d ago

Spatiotemporal Hyperedges for EEG Seizure Detection and Prediction

The paper introduces HyBrain, a model that uses spatiotemporal hyperedges to capture coordinated EEG seizure activity more efficiently than pairwise edge approaches. By generating one token per channel per second and pooling them into shared hyperedge embeddings, HyBrain performs well across detection and prediction tasks on TUSZ and CHB‑MIT datasets, achieving top AUROC scores and competitive training resources. A qualitative example shows a single hyperedge tracking the preictal‑ictal‑postictal progression of a real seizure.

By Hyunju Kim, Sheo Yon Jhin, Noseong Park, Nabil Imam
arXiv Machine Learning
Sep 16

Explainable Graph-theoretical Machine Learning with Application to Alzheimer's Disease Prediction

The paper introduces Explainable Graph-theoretical Machine Learning (XGML) to build individual metabolic brain graphs from FDG-PET data and identify subgraphs predictive of multivariate Alzheimer’s disease outcomes. Using ADNI data, the best model—kernel density estimation with Hellinger distance and random forest—achieved a Pearson correlation of 0.595 across eight cognitive scores, with the highest performance on ADAS13, ADAS11, and ADASQ4. Key edges were found to be jointly but differentially predictive, indicating potential network biomarkers for cognitive decline, though external validation on OASIS3 showed weaker performance likely due to cohort differences.

By Narmina Baghirova, Duy-Thanh V\~u, Duy-Cat Can, Christelle Schneuwly Diaz, Julien Bodlet, Guillaume Blanc, Georgi Hrusanov, Bernard Ries, Oliver Y. Ch\'en